Cited by 214RNA and protein synthesis mechanismsDNA and Nucleic Acid ChemistryRNA Research and Splicing

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RNA pseudoknots: Translational frameshifting and readthrough on viral RNAs

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Ten Dam, Edwin B., Pleij, Cornelius W. A., Bosch, Leendert·1990·Virus Genes

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Abstract

Ribosomal frameshifting on retroviral RNAs has been proposed to be mediated by slippage of two adjacent tRNAs into the -1 direction at a specific heptanucleotide sequence. Here we report a computer-aided analysis of the structure around the established or putative frameshift sites in a number of retroviral, coronaviral, toroviral, and luteoviral RNAs and two dsRNA yeast viruses. In almost all cases a stable hairpin was predicted four to nine nucleotides downstream of the shifty heptanucleotide. More than half of the resulting hairpin loops give rise to potential pseudoknotting with sequences downstream of this hairpin. Especially in the case of the shifty heptanucleotides U UUA AAC and G GGA AAC, stable downstream pseudoknots are present. Indications were also found for the presence of pseudoknots downstream of amber stop condons at readthrough sites in some retroviral RNAs.

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Authors: Ten Dam, E. B., Pleij, C. W. A., & Bosch, L.
Affiliations: Leiden University (NL)
Venue: Virus Genes
Publisher: Springer Science and Business Media LLC
Published: 1990-07
Volume: 4
Issue: 2
Pages: 121-136
ISSN: 0920-8569 (ISSN-L)
1572-994X
DOI: 10.1007/bf00678404
PMC: PMC7089070
OpenAlex: W2067191137
Cited by: 214
References: 55
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 4
FWCI: 5.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
Locations: Virus Genes (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: RNA pseudoknots, ribosomal frameshifting, translational readthrough, retroviral RNA, amber stop codon, RNA secondary structure prediction
MeSH terms: Electronic Data Processing, Base Sequence, Codon, Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Retroviridae, RNA, Viral, Suppression, Genetic, Protein Biosynthesis

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RNA pseudoknots: Translational frameshifting and readthrough on viral RNAs

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