The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
RNA pseudoknots: Translational frameshifting and readthrough on viral RNAs
Open accessAbstract
Ribosomal frameshifting on retroviral RNAs has been proposed to be mediated by slippage of two adjacent tRNAs into the -1 direction at a specific heptanucleotide sequence. Here we report a computer-aided analysis of the structure around the established or putative frameshift sites in a number of retroviral, coronaviral, toroviral, and luteoviral RNAs and two dsRNA yeast viruses. In almost all cases a stable hairpin was predicted four to nine nucleotides downstream of the shifty heptanucleotide. More than half of the resulting hairpin loops give rise to potential pseudoknotting with sequences downstream of this hairpin. Especially in the case of the shifty heptanucleotides U UUA AAC and G GGA AAC, stable downstream pseudoknots are present. Indications were also found for the presence of pseudoknots downstream of amber stop condons at readthrough sites in some retroviral RNAs.
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“The mechanism of translational readthrough involves suppressing the termination codon at the end of the gag gene, thereby maintaining the same reading frame during the translation of Gag and Pol, as has been observed in MLV (Yoshinaka et al. 1985a, ten Dam et al. 1990, Wills et al. 1991, Goff 2004).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as ten Dam et al. 1990
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Cites
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Cited by
Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme
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Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily
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Pseudoknots: RNA Structures with Diverse Functions
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Metadata
- Authors
- Ten Dam, E. B., Pleij, C. W. A., & Bosch, L.
- Affiliations
- Leiden University (NL)
- Venue
- Virus Genes
- Published
- 1990-07
- Volume
- 4
- Issue
- 2
- Pages
- 121-136
- ISSN
- 0920-8569 (ISSN-L)
- 1572-994X
- PMC
- PMC7089070
- OpenAlex
- W2067191137
- Cited by
- 214
- References
- 55
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 4
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- www.springer.com/tdm (tdm)
- Locations
- Virus Genes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- RNA pseudoknots, ribosomal frameshifting, translational readthrough, retroviral RNA, amber stop codon, RNA secondary structure prediction
- MeSH terms
- Electronic Data Processing, Base Sequence, Codon, Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Retroviridae, RNA, Viral, Suppression, Genetic, Protein Biosynthesis
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
