Inadequacy of musocal IgM antibodies in selective IgA deficiency: Excretion of attenuated polio viruses is prolonged
Abstract
A nationwide vaccination campaign with oral poliovirus vaccine was organized in Finland in 1985 in order to cease an outbreak of poliomyelitis. We followed eight IgA-deficient individuals and nine controls for poliovirus excretion in feces and for antibody responses in serum and saliva. Five weeks after oral poliovirus vaccination all eight IgA-deficient individuals were still excreting polioviruses, in contrast to one of nine controls. The concentration of polioviruses, as estimated by a semi-quantitative immunofluorescent assay, was generally higher and the test was significantly more often positive in the samples from the IgA-deficient individuals. Although serum levels of antibodies to poliovirus type 3 were lower in IgA-deficient individuals before vaccination, both measurements showed that the two groups had similar antibody levels 4 weeks after vaccination. IgA-deficient individuals lacked salivary IgA antibodies to poliovirus types 1 and 3 but had increased levels of IgM antipolio antibodies, which were shown to carry secretory component. We conclude that the mucosal IgM antibodies of IgA-deficient individuals eliminate polioviruses less efficiently than do the IgA antibodies of normal individuals.
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Soon after the additional testing requirements, cVDPV was detected in the Philippines.
“Soon afterwards, cVDPV was detected in the Philippines (177).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [177]
Most observed recombination sites map to the noncapsid region.
“most of the observed recombination sites map to the noncapsid region”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [177]
Although the cVDPV isolates from Egypt, Hispaniola, and the Philippines were antigenic variants of the Sabin strains, variability among the surface determinants was limited despite the high degree of nucleotide divergence among many of the isolates.
“Although the cVDPV isolates from Egypt, Hispaniola, and the Philippines were antigenic variants of the Sabin strains, variability among the surface determinants was limited despite the high degree of nucleotide divergence among many of the isolates”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [177]
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- Authors
- Savilahti, E., Klemola, T., Carlsson, B., Mellander, L., Stenvik, M., & Hovi, T.
- Affiliations
- University of Helsinki (FI)
- University of Gothenburg (SE)
- Venue
- Journal of Clinical Immunology
- Published
- 1988-03
- Volume
- 8
- Issue
- 2
- Pages
- 89-94
- ISSN
- 0271-9142 (ISSN-L)
- 1573-2592
- OpenAlex
- W2073672033
- Cited by
- 52
- References
- 13
- Citations by year
- 2024: 1 · 2023: 3 · 2021: 1 · 2019: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- selective IgA deficiency, oral polio vaccine, attenuated poliovirus, secretory IgA, salivary IgA, secretory component, poliovirus type 3, poliomyelitis outbreak, vaccine antibody response
- MeSH terms
- Adolescent, Adult, Child, Dysgammaglobulinemia, Enzyme-Linked Immunosorbent Assay, Feces, Fluorescent Antibody Technique, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Mucous Membrane, Poliovirus Vaccine, Oral, Saliva, Time Factors, IgA Deficiency, Poliovirus
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