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Cited by 109Neuroscience and Neuropharmacology ResearchIon Transport and Channel RegulationMitochondrial Function and Pathology

High extracellular potassium concentrations stimulate oxidative metabolism in a glutamatergic neuronal culture and glycolysis in cultured astrocytes but have no stimulatory effect in a GABAergic neuronal culture

Peng, Liang, Zhang, Xiaohu, Leif, Hertz·1994·Brain Research
DOI 10.1016/0006-8993(94)90475-8
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Abstract

Rates of deoxyglucose accumulation and of CO2 production from [U-14C]glucose, or from [U-14C]lactate or [2-14C]pyruvate (as a determination of tricarboxylic acid (TCA) cycle activity) were determined in primary cultures of either astrocytes, cerebellar granule cell neurons (utilizing glutamate as their transmitter) or cerebral cortical interneurons (utilizing GABA as their transmitter) during control ('resting') conditions and during exposure to an elevated extracellular potassium concentration, mimicking functional activity. The elevation of the extracellular potassium concentration increased the rate of deoxyglucose accumulation, but not of TCA cycle activity in astrocytes and both deoxyglucose accumulation and TCA cycle activity in cerebellar granule cells, but had no stimulatory effect in cerebral cortical neurons. Based on these observations it is suggested that the increase in energy metabolism in the CNS in vivo during functional activity mainly reflects increased active accumulation of potassium ions and extrusion of sodium ions in neurons receiving excitatory input and in adjacent astrocytes in order to re-establish pre-stimulus ion distribution across cell membranes.

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  • Astrocytic lactate production can be stimulated by glutamate and potassium.

    “Astrocytes can indeed produce lactate from glucose (Hertz et al., 1988; Magistretti et al., 1993), and this lactate production can be stimulated by glutamate and potassium, which become elevated during neuronal activity (Walz and Mukerji, 1988; Peng et al., 1994; Pellerin and Magistretti, 1996; Bittner et al., 2011).”

    From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Peng et al., 1994

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Authors
Peng, L., Zhang, X., & Leif, H.
Affiliations
University of Saskatchewan (CA)
ORCID
Zhang, Xiaohu
Venue
Brain Research
Publisher
Elsevier BV
Published
1994-11
Volume
663
Issue
1
Pages
168-172
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(94)90475-8
OpenAlex
W2025321521
Cited by
109
References
31
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 7 · 2017: 4 · 2016: 6 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
1.55
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
extracellular potassium, neuronal energy metabolism, astrocytes, cerebellar granule cells, cortical interneurons, glutamatergic neurons, GABAergic neurons, glycolysis, TCA cycle, potassium accumulation, sodium extrusion, neuronal activity
MeSH terms
Animals, Astrocytes, Biological Transport, Carbon Radioisotopes, Cells, Cultured, Cerebellum, Cerebral Cortex, Citric Acid Cycle, Deoxyglucose, gamma-Aminobutyric Acid, Glucose, Kinetics, Lactates, Neurons, Potassium, Pyruvates, Glutamic Acid, Mice, Rats

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