The investigation of linkage between a quantitative trait and a marker locus

Common SNPs explain a large proportion of the heritability for human height

Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2010) · Nature Genetics · doi:10.1038/ng.608 · Cited by 4,446

The Genetic Architecture of Quantitative Traits

Mackay, T. F. C. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090633 · Cited by 1,106

A General Test of Association for Quantitative Traits in Nuclear Families

Abecasis, G. R., Cardon, L. R., & Cookson, W. O. C. (2000) · The American Journal of Human Genetics · doi:10.1086/302698 · Cited by 1,126

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

Gusev, A., Lee, S. H., Trynka, G., Finucane, H., Vilhjálmsson, B. J., Xu, H., Zang, C., Ripke, S., Bulik-Sullivan, B., Stahl, E., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.10.004 · Cited by 544

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Loh, P.-R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., de Candia, T. R., Lee, S. H., Wray, N. R., et al. (2015) · Nature Genetics · doi:10.1038/ng.3431 · Cited by 449

Improved polygenic prediction by Bayesian multiple regression on summary statistics

Lloyd-Jones, L. R., Zeng, J., Sidorenko, J., Yengo, L., Moser, G., Kemper, K. E., Wang, H., Zheng, Z., Magi, R., Esko, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12653-0 · Cited by 528

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data

Shi, H., Kichaev, G., & Pasaniuc, B. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.05.013 · Cited by 387

Combined Linkage and Association Sib-Pair Analysis for Quantitative Traits

Fulker, D. W., Cherny, S. S., Sham, P. C., & Hewitt, J. K. (1999) · The American Journal of Human Genetics · doi:10.1086/302193 · Cited by 443

Theory and practice in quantitative genetics

Posthuma, D., Beem, A. L., de Geus, E. J. C., van Baal, G. C. M., von Hjelmborg, J. B., Iachine, I., & Boomsma, D. I. (2003) · Twin Research · doi:10.1375/136905203770326367 · Cited by 416

Measuring missing heritability: Inferring the contribution of common variants

Golan, D., Lander, E. S., & Rosset, S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419064111 · Cited by 288

Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification

Dapas, M., & Dunaif, A. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac001 · Cited by 300

Hints of hidden heritability in GWAS

Gibson, G. (2010) · Nature Genetics · doi:10.1038/ng0710-558 · Cited by 281

Power of Linkage versus Association Analysis of Quantitative Traits, by Use of Variance-Components Models, for Sibship Data

Sham, P. C., Cherny, S. S., Purcell, S., & Hewitt, J. K. (2000) · The American Journal of Human Genetics · doi:10.1086/302891 · Cited by 260

Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration

Iyengar, S. K., Song, D., Klein, B. E. K., Klein, R., Schick, J. H., Humphrey, J., Millard, C., Liptak, R., Russo, K., Jun, G., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/380912 · Cited by 173

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

Hivert, V., Sidorenko, J., Rohart, F., Goddard, M. E., Yang, J., Wray, N. R., Yengo, L., & Visscher, P. M. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.02.014 · Cited by 136

Allelic Variation at Alcohol Metabolism Genes (ADH1B, ADH1C, ALDH2) and Alcohol Dependence in an American Indian Population

Mulligan, C. J., Robin, R. W., Osier, M. V., Sambuughin, N., Goldfarb, L. G., Kittles, R. A., Hesselbrock, D., Goldman, D., & Long, J. C. (2003) · Human Genetics · doi:10.1007/s00439-003-0971-z · Cited by 102

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

Hou, K., Burch, K. S., Majumdar, A., Shi, H., Mancuso, N., Wu, Y., Sankararaman, S., & Pasaniuc, B. (2019) · Nature Genetics · doi:10.1038/s41588-019-0465-0 · Cited by 91

The HERITAGE family study: a review of the effects of exercise training on cardiometabolic health, with insights into molecular transducers

SARZYNSKI, M. A., RICE, T. K., DESPRÉS, J.-P., PÉRUSSE, L., TREMBLAY, A., STANFORTH, P. R., TCHERNOF, A., BARBER, J. L., FALCIANI, F., CLISH, C., et al. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002859 · Cited by 62

Efficient variance components analysis across millions of genomes

Pazokitoroudi, A., Wu, Y., Burch, K. S., Hou, K., Zhou, A., Pasaniuc, B., & Sankararaman, S. (2020) · Nature Communications · doi:10.1038/s41467-020-17576-9 · Cited by 55

Gene‐Trait Similarity Regression for Multimarker‐Based Association Analysis

Tzeng, J., Zhang, D., Chang, S., Thomas, D. C., & Davidian, M. (2009) · Biometrics · doi:10.1111/j.1541-0420.2008.01176.x · Cited by 50

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Chua, M., Solanes, G., Zheng, M., Zhao, L., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1890 · Cited by 48

Genetic variation in radiation-induced cell death

Smirnov, D. A., Brady, L., Halasa, K., Morley, M., Solomon, S., & Cheung, V. G. (2012) · Genome Research · doi:10.1101/gr.122044.111 · Cited by 46

Social-Science Genomics: Progress, Challenges, and Future Directions

Benjamin, D., Cesarini, D., Turley, P., & Young, A. S. (2024) · doi:10.3386/w32404 · Cited by 20

Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypes

Wessel, J., Schork, A. J., Tiwari, H. K., & Schork, N. J. (2007) · Genetic Epidemiology · doi:10.1002/gepi.20241 · Cited by 12