The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
Abstract
The rates of utilization of both glucose and glutamine are high in rapidly dividing ceils such as enterocytes, lymphocytes, thymocytes, tumour cells; the oxidation of both glucose and glutamine is only partial, glucose to lactate and glutamine to glutamate, alanine or aspartate; and these partial processes are termed glycolysis and glutaminolysis respectively. Both processes generate energy and also provide precursors for important biosynthetic processes in such cells. However, the rates of utilization of precursors for macromolecular biosynthesis are very low in comparison to the rates oi partial oxidation, and energy generation per se may not be the correct explanation for high rates of glycolysis and glutaminolysis in these cells since oxidation is only partial and other fuels can be used to generate energy. Both the high fluxes and the metabolic characteristics of these two processes can be explained by application of quantitative principles of control as applied to branched metabolic pathway s (Crabtree & Newsholme, 1985). If the flux through one branch is greatly in excess of the other, then the sensitivity of the flux of the low-flux pathway to regulators is very high. Hence, it is suggested that, in rapidly dividing ceils, high rates of glycolysis and gtutaminolysis are required not for energy or precursor provision per se but for high sensitivity of the pathways involved in the use of precursors for macromolecular synthesis to specific regulators to permithigh rates of proliferation when required for example, in lymphocytes in response to a massive infection.
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Cites
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
On Respiratory Impairment in Cancer Cells
Warburg, O. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,468
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.
Reitzer, L. J., Wice, B. M., & Kennell, D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30124-2 · Cited by 1,240
Utilization of Nutrients by Isolated Epithelial Cells of the Rat Colon
Roediger, W. E. W. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80339-9 · Cited by 1,191
Biochemistry for the Medical Sciences
Newsholme, E. A., & Leech, A. R. (1983) · Andalas University Repository (Andalas University) · Cited by 942
Self-citationUptake and Metabolism of Plasma Glutamine by the Small Intestine
Windmueller, H. G., & Spaeth, A. E. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42329-6 · Cited by 790
Glutamine metabolism in lymphocytes of the rat
Ardawi, M. S. M., & Newsholme, E. A. (1983) · Biochemical Journal · doi:10.1042/bj2120835 · Cited by 440
Self-citationMitochondrial metabolism of glutamine and glutamate and its physiological significance.
Kovacevic, Z., & McGivan, J. D. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.2.547 · Cited by 374
Glycolysis, glutaminolysis and cell proliferation
MCKEEHAN, W. (1982) · Cell Biology International Reports · doi:10.1016/0309-1651(82)90125-4 · Cited by 305
Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts
Ronald Zielke, H., Ozand, P. T., Tyson Tildon, J., Sevdalian, D. A., & Cornblath, M. (1978) · Journal of Cellular Physiology · doi:10.1002/jcp.1040950106 · Cited by 273
Isolation and metabolic characteristics of rat and chicken enterocytes
Watford, M., Lund, P., & Krebs, H. A. (1979) · Biochemical Journal · doi:10.1042/bj1780589 · Cited by 252
Glutamine Metabolism in Mammalian Tissues
(1984) · Springer eBooks · doi:10.1007/978-3-642-69754-8 · Cited by 238
Ardawi, M. S. M., & Newsholme, E. A. (1982) · Biochemical Journal · doi:10.1042/bj2080743 · Cited by 223
Self-citationGlutamine: Metabolism, Enzymology, and Regulation
(1980) · Elsevier eBooks · doi:10.1016/b978-0-125-06040-0.x5001-8 · Cited by 215
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes
Roos, D., & Loos, J. A. (1973) · Experimental Cell Research · doi:10.1016/0014-4827(73)90561-2 · Cited by 182
Aerobic glycolysis and lymphocyte transformation
Hume, D. A., Radik, J. L., Ferber, E., & Weidemann, M. J. (1978) · Biochemical Journal · doi:10.1042/bj1740703 · Cited by 172
A Quantitative Approach to Metabolic Control
Crabtree, B., & Newsholme, E. A. (1985) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152825-6.50006-0 · Cited by 140
Self-citationMetabolism and transport of glutamine and glucose in vascularly perfused small intestine of the rat
Hanson, P. J., & Parsons, D. S. (1977) · Biochemical Journal · doi:10.1042/bj1660509 · Cited by 124
Concentrations of Metabolites in Animal Tissues
Williamson, D., & Brosnan, J. T. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091304-6.50093-8 · Cited by 95
Role and Regulation of Glucose Metabolism in Proliferating Cells
Hume, D. A., & Weidemann, M. J. (1979) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/62.1.3 · Cited by 80
Glucose and glutamine metabolism in rat thymocytes
Brand, K., Williams, J. F., & Weidemann, M. J. (1984) · Biochemical Journal · doi:10.1042/bj2210471 · Cited by 76
Glutamine metabolism in the rat
Lund, P. (1980) · FEBS Letters · doi:10.1016/0014-5793(80)80573-4 · Cited by 73
Special Lecture: Glutamine Metabolism in the Animal Body
Krebs, H. A. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-506040-0.50023-6 · Cited by 60
Carbohydrate metabolism in cultured animal cells
Morgan, M. J., & Faik, P. (1981) · Bioscience Reports · doi:10.1007/bf01116465 · Cited by 55
Metabolism of renal tumors in situ and during ischemia.
Dh, W., Ha, K., Stubbs, M., et al. (1970) · PubMed · Cited by 29
Glutamine Metabolism in Lymphoid Tissues
Ardawi, M. S., & Newsholme, P. (1984) · Springer eBooks · doi:10.1007/978-3-642-69754-8_15 · Cited by 25
Self-citation(1979) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/62.3.co3 · Cited by 25
Babineau, S. E. (2016) · doi:10.1002/9781118621042.ch29 · Cited by 3
Cited by
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140
“Early studies showed that polyclonal mitogens such as concanavalin A and phytohaemagglutinin drive the upregulation of glycolysis and glutamine oxidation in thymocytes and mature lymphocytes (Brand et al., 1984; Newsholme et al., 1985b).”
BackgroundResultInfluentialFrom Krebs to clinic: glutamine metabolism to cancer therapy
Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119
Metadata
- Authors
- Newsholme, E. A., Crabtree, B., & Ardawi, M. S. M.
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 1985-05-01
- Volume
- 5
- Issue
- 5
- Pages
- 393-400
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- OpenAlex
- W1972806358
- Cited by
- 364
- References
- 28
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
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