Cited by 1,240Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismMetabolism, Diabetes, and Cancer

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

Open access
Reitzer, L.J., Wice, B.M., Kennell, D.·1979·Journal of Biological Chemistry

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Integrity signals

Registry

Crossref · 10.1016/s0021-9258(17)30124-2

Cites

39 of 39 references verified0 citation errors · 0 not checkable

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  • Glutamine is a major nutrient source for oxidative metabolism in some cancer cell lines.

    “glutamine has been confirmed to be a major nutrient source for oxidative metabolism in some cancer cell lines10–12”

    From Glutamine reliance in cell metabolism (2020) · cites this paper as [12]

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Cites

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Research works printed but not linked: 5

  1. Cristofalo, V. J., and Kritchevsky, D. (1966) Proc. Sot. Exp. Biol. Med. 118,1109-1113
  2. Paul, J., and Pearson, E. (1956) Biochem. J. 63, 16p
  3. Zielke, H. R., Ozand, P. T., Tildon, J. T., Sevdalian, D. A., and Cornblatt, M. (1976) Proc. Natl. Acad. Sci. U. S. A. 73, 4110- 4114
  4. Lavietes, B. B., Regan, D. H., and Demopoulos, H. B. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 3993-3997
  5. MacDonald, D. L. (1972) in The Carbohydrates (Pigman, W., and Horton, D., eds) pp. 253-278, Academic Press, New York

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Authors
Reitzer, L. J., Wice, B. M., & Kennell, D.
Affiliations
Washington University in St. Louis (US)
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1979-04
Volume
254
Issue
8
Pages
2669-2676
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1483212110
Cited by
1,240
References
39
Citations by year
2026: 14 · 2025: 19 · 2024: 30 · 2023: 40 · 2022: 24 · 2021: 45 · 2020: 31 · 2019: 28 · 2018: 42 · 2017: 42 · 2016: 38 · 2015: 38 · 2014: 48 · 2013: 36 · 2012: 46
FWCI
12.54
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
American Cancer Society
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
glutamine, glucose, energy metabolism, HeLa cells, cultured cells, energy sources
MeSH terms
Adenosine Diphosphate, Adenosine Triphosphate, Citric Acid Cycle, Fructose, Galactose, Glucose, Glutamine, HeLa Cells, Humans, Kinetics, Lactates, Pentoses

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