Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.
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Glutamine is a major nutrient source for oxidative metabolism in some cancer cell lines.
“glutamine has been confirmed to be a major nutrient source for oxidative metabolism in some cancer cell lines10–12”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [12]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
A Flexible System of Enzymatic Analysis
Lowry, O. H., & Passonneau, J. V. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-457950-7.x5001-3 · Cited by 4,050 · see citing works
Nutrition Needs of Mammalian Cells in Tissue Culture
Eagle, H. (1955) · Science · doi:10.1126/science.122.3168.501 · Cited by 1,619 · see citing works
Patterson, M. S., & Greene, R. C. (1965) · Analytical Chemistry · doi:10.1021/ac60226a017 · Cited by 1,459 · see citing works
Uptake and Metabolism of Plasma Glutamine by the Small Intestine
Windmueller, H. G., & Spaeth, A. E. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42329-6 · Cited by 791 · see citing works
The Path of Carbon in Photosynthesis. V. Paper Chromatography and Radioautography of the Products1
Benson, A. A., Bassham, J. A., Calvin, M., Goodale, T. C., Haas, V. A., & Stepka, W. (1950) · Journal of the American Chemical Society · doi:10.1021/ja01160a080 · Cited by 479 · see citing works
The Use of Glucose-C14 for the Evaluation of the Pathways of Glucose Metabolism
Katz, J. J., & Wood, H. G. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64593-4 · Cited by 405 · see citing works
Alp, P. R., Newsholme, E. A., & Zammit, V. A. (1976) · Biochemical Journal · doi:10.1042/bj1540689 · Cited by 404 · see citing works
Uber den Stoffwechsel der Karzinomezellen
Warburg, O. (1924) · Medical Entomology and Zoology · Cited by 401 · see citing works
A new method for the determination of inulin in plasma and urine
Heyrovský, A. (1956) · Clinica Chimica Acta · doi:10.1016/0009-8981(56)90020-1 · Cited by 377 · see citing works
Regulatory Mechanisms in Carbohydrate Metabolism
Wu, R. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69674-7 · Cited by 229 · see citing works
Wilson, D. F., Stubbs, M., Veech, R. L., Erecińska, M., & Krebs, H. A. (1974) · Biochemical Journal · doi:10.1042/bj1400057 · Cited by 218 · see citing works
Renner, E. D., Plagemann, P. G. W., & Bernlohr, R. W. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44825-4 · Cited by 217 · see citing works
GLUTAMINE AS SOURCE MATERIAL OF URINARY AMMONIA
Slyke, D. D. V., Phillips, R. A., Hamilton, P., Archibald, R. M., Futcher, P. H., & Hiller, A. (1943) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)72173-x · Cited by 208 · see citing works
The Utilization of Carbohydrates by Human Cell Cultures
Eagle, H., Barban, S., Levy, M., & Schulze, H. O. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64702-7 · Cited by 207 · see citing works
Energy metabolism in respiration‐deficient and wild type chinese hamster fibroblasts in culture
Donnelly, M. I., & Scheffler, I. E. (1976) · Journal of Cellular Physiology · doi:10.1002/jcp.1040890105 · Cited by 150 · see citing works
STUDIES OF TISSUE PERMEABILITY
Crane, R. K., Field, R. A., Cori, C. F., & Roberts, M. L. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64957-9 · Cited by 138 · see citing works
Biochemistry of Cultured Mammalian Cells
Levintow, L., & Eagle, H. (1961) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.30.070161.003133 · Cited by 129 · see citing works
Growth of human diploid fibroblasts in the absence of glucose utilization.
Zielke, H. R., Ozand, P. T., Tildón, J. T., Sevdalian, D. A., & Cornblath, M. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.4110 · Cited by 106 · see citing works
EFFECT OF ANIONS ON THE NON-ENZYMATIC DESAMIDATION OF GLUTAMINE
Gilbert, J. B., Price, V., & Greenstein, J. P. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56737-5 · Cited by 100 · see citing works
Munyon, W. H., & Merchant, D. J. (1959) · Experimental Cell Research · doi:10.1016/0014-4827(59)90069-2 · Cited by 93 · see citing works
Growth of cultured mammalian cells on secondary glucose sources
Rheinwald, J. G., & Green, H. (1974) · Cell · doi:10.1016/0092-8674(74)90023-3 · Cited by 71 · see citing works
Bae, I., & Foote, R. H. (1975) · Experimental Cell Research · doi:10.1016/0014-4827(75)90148-2 · Cited by 58 · see citing works
Amino acid utilization by L-M strain mouse cells in a chemically defined medium
Stoner, G. D., & Merchant, D. J. (1972) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02661723 · Cited by 56 · see citing works
Factors Affecting Blastocyst Expansion of Rabbit Zygotes and Young Embryos in Defined Media
Kane, M. T., & Foote, R. H. (1971) · Biology of Reproduction · doi:10.1093/biolreprod/4.1.41 · Cited by 52 · see citing works
Glutamate Oxidation in 6C3HED Lymphoma: Effects of L-Asparaginase on Sensitive and Resistant Lines
Lavietes, B. B., Regan, D. H., & Demopoulos, H. B. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.10.3993 · Cited by 48 · see citing works
Utilization of glutamine for energy and protein synthesis by cultured rabbit follicular oocytes
Bae, I., & Foote, R. H. (1975) · Experimental Cell Research · doi:10.1016/0014-4827(75)90333-x · Cited by 47 · see citing works
Growth and Glycolysis in the Human Diploid Cell Strain WI-38.
Cristofalo, V. J., & Kritchevsky, D. (1965) · Experimental Biology and Medicine · doi:10.3181/00379727-118-30057 · Cited by 45 · see citing works
The Significance of Glycolysis 2
Graff, S., Moser, H., Kastner, O., Graff, A. M., & Tannenbaum, M. (1965) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/34.4.511 · Cited by 36 · see citing works
Glutamine and Glutamate as Respiratory Substrates of Rabbit Reticulocytes
Rapoport, S. M., Rost, J., & Schultze, M. (1971) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1971.tb01604.x · Cited by 35 · see citing works
CULTURE OF TWO-CELL RABBIT EMBRYOS TO MORULAE
Brinster, R. L. (1970) · Reproduction · doi:10.1530/jrf.0.0210017 · Cited by 34 · see citing works
Fibroblasts as an Experimental Tool in Metabolic and Hormone Studies
Morell, B., & Froesch, E. R. (1973) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1973.tb00337.x · Cited by 33 · see citing works
Bailey, J. M., Gey, G. O., & Gey, M. K. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98126-3 · Cited by 28 · see citing works
THE METABOLISM OF TISSUE CULTURES
Wilson, H., Jackson, E. B., & Brues, A. M. (1942) · The Journal of General Physiology · doi:10.1085/jgp.25.5.689 · Cited by 25 · see citing works
Effect of Asparagine and Glutamine Deficiency on Normal and Leukemic Cells 2
Schrèk, R., Holcenberq, J. S., Batra, K. V., Roberts, J., & Dolowy, W. C. (1973) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/51.4.1103 · Cited by 22 · see citing works
Asparaginase and glutaminase activities in culture media containing dialyzed fetal calf serum
Wein, J., & Goetz, I. E. (1973) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02618436 · Cited by 19 · see citing works
An Alteration in Glucose Metabolism Associated with a Defect in Ketone Body Metabolism
Tildón, J. T. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.1.210 · Cited by 8 · see citing works
[13] Estimation of Fructokinase (ketohexokinase) in crude tissue preparations
Weiser, M. M., & Quill, H. (1975) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(75)41015-1 · Cited by 6 · see citing works
Expressing tissue culture respiration
Phillips, H. J., Andrews, R. V., & Skank, V. (1960) · Experimental Cell Research · doi:10.1016/0014-4827(60)90136-1 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Cristofalo, V. J., and Kritchevsky, D. (1966) Proc. Sot. Exp. Biol. Med. 118,1109-1113
- Paul, J., and Pearson, E. (1956) Biochem. J. 63, 16p
- Zielke, H. R., Ozand, P. T., Tildon, J. T., Sevdalian, D. A., and Cornblatt, M. (1976) Proc. Natl. Acad. Sci. U. S. A. 73, 4110- 4114
- Lavietes, B. B., Regan, D. H., and Demopoulos, H. B. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 3993-3997
- MacDonald, D. L. (1972) in The Carbohydrates (Pigman, W., and Horton, D., eds) pp. 253-278, Academic Press, New York
Cited by
Sorted by citations
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744 · see citing works
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057 · see citing works
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.016 · Cited by 2,204 · see citing works
From Krebs to clinic: glutamine metabolism to cancer therapy
Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works
Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124 · see citing works
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798 · see citing works
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003428107 · Cited by 1,742 · see citing works
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
DeBerardinis, R. J., & Cheng, T. (2010) · Oncogene · doi:10.1038/onc.2009.358 · Cited by 1,365 · see citing works
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Mullen, A. R., Wheaton, W. W., Jin, E. S., Chen, P.-H., Sullivan, L. B., Cheng, T., Yang, Y., Linehan, W. M., Chandel, N. S., & DeBerardinis, R. J. (2012) · Nature · doi:10.1038/nature10642 · Cited by 1,328 · see citing works
Glutamine and cancer: cell biology, physiology, and clinical opportunities
Hensley, C. T., Wasti, A. T., & DeBerardinis, R. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69600 · Cited by 1,262 · see citing works
An improved culture medium supports development of random-bred 1-cell mouse embryos in vitro
Chatot, C. L., Ziomek, C. A., Bavister, B. D., Lewis, J. L., & Torres, I. (1989) · Reproduction · doi:10.1530/jrf.0.0860679 · Cited by 1,114 · see citing works
Imamura, H., Nhat, K. P. H., Togawa, H., Saito, K., Iino, R., Kato‐Yamada, Y., Nagai, T., & Noji, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904764106 · Cited by 1,089 · see citing works
Energy metabolism in tumor cells
Moreno‐Sánchez, R., Rodríguez‐Enríquez, S., Marín‐Hernández, Á., & Saavedra, E. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05686.x · Cited by 1,086 · see citing works
Glutamine reliance in cell metabolism
Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works
Brick by brick: metabolism and tumor cell growth
DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.02.003 · Cited by 1,018 · see citing works
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
de la Cruz-López, K. G., Castro-Muñoz, L. J., Reyes-Hernández, D. O., García-Carrancá, A., & Manzo-Merino, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01143 · Cited by 940 · see citing works
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)
Zheng, J. (2012) · Oncology Letters · doi:10.3892/ol.2012.928 · Cited by 953 · see citing works
MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
Dang, C. V., Le, A., & Gao, P. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0889 · Cited by 934 · see citing works
Miller, D. M., Thomas, S. D., Islam, A., Muench, D. E., & Sedoris, K. C. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0977 · Cited by 844 · see citing works
Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells
Rossignol, R., Gilkerson, R., Aggeler, R., Yamagata, K., Remington, S., & Capaldi, R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1101 · Cited by 865 · see citing works
Pyruvate kinase type M2 and its role in tumor growth and spreading
Mazurek, S., Boschek, C. B., Hugo, F., & Eigenbrodt, E. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.04.009 · Cited by 812 · see citing works
Suzuki, S., Tanaka, T., Poyurovsky, M. V., Nagano, H., Mayama, T., Ohkubo, S., Lokshin, M., Hosokawa, H., Nakayama, T., Suzuki, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002459107 · Cited by 705 · see citing works
Ye, J., Kumanova, M., Hart, L. S., Sloane, K. L., Zhang, H., Panis, D. N. D., Bobrovnikova-Marjon, E. V., Diehl, J. A., Ron, D., & Koumenis, C. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.81 · Cited by 709 · see citing works
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
Yuneva, M., Zamboni, N., Oefner, P., Sachidanandam, R., & Lazebnik, Y. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703099 · Cited by 690 · see citing works
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
Mazurek, S. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.02.005 · Cited by 694 · see citing works
Seyfried, T. N., & Shelton, L. M. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-7 · Cited by 656 · see citing works
van der Valk, J., Brunner, D., Smet, K. D., Svenningsen, Å. F., Honegger, P., Knudsen, L. E., Lindl, T., Noraberg, J., Price, A., Scarino, M. L., et al. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.03.016 · Cited by 657 · see citing works
Is Glutamine a Conditionally Essential Amino Acid?
Lacey, J. M., & Wilmore, D. W. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1990.tb02967.x · Cited by 808 · see citing works
Mitochondrial bioenergetics and structural network organization
Benard, G., Bellance, N., James, D., Parrone, P., Fernandez, H., Letellier, T., & Rossignol, R. (2007) · Journal of Cell Science · doi:10.1242/jcs.03381 · Cited by 618 · see citing works
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
Csibi, A., Fendt, S.-M., Li, C., Poulogiannis, G., Choo, A. Y., Chapski, D. J., Jeong, S. M., Dempsey, J. M., Parkhitko, A., Morrison, T., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.023 · Cited by 586 · see citing works
Timmerman, L. A., Holton, T., Yuneva, M., Louie, R. J., Padró, M., Daemen, A., Hu, M., Chan, D. A., Ethier, S. P., van ‘t Veer, L. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.08.020 · Cited by 573 · see citing works
The emerging role and targetability of the TCA cycle in cancer metabolism
Anderson, N. M., Mucka, P., Kern, J. G., & Feng, H. (2017) · Protein & Cell · doi:10.1007/s13238-017-0451-1 · Cited by 558 · see citing works
Windmueller, H. G., & Spaeth, A. E. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86270-1 · Cited by 532 · see citing works
Choosing between glycolysis and oxidative phosphorylation: a tumor’s dilemma?
Jose, C., Bellance, N., & Rossignol, R. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.10.012 · Cited by 518 · see citing works
Roles of p53, MYC and HIF-1 in regulating glycolysis–the seventh hallmark of cancer
Yeung, S. J., Pan, J., & Lee, M.-H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8224-x · Cited by 514 · see citing works
Glutamine Metabolism by the Intestinal Tract
Souba, W. W., Smith, R. J., & Wilmore, D. W. (1985) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607185009005608 · Cited by 508 · see citing works
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
Zahra, K., Dey, T., Ashish, Mishra, S. P., & Pandey, U. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00159 · Cited by 507 · see citing works
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
Cheng, T., Sudderth, J., Yang, C., Mullen, A. R., Jin, E. S., Matés, J. M., & DeBerardinis, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016627108 · Cited by 475 · see citing works
Diaz-Ruiz, R., Rigoulet, M., & Devin, A. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.08.010 · Cited by 486 · see citing works
Glutamine Utilization by the Small Intestine
Windmueller, H. G. (1982) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122983.ch6 · Cited by 484 · see citing works
Miller, W. M., Blanch, H. W., & Wilke, C. R. (1988) · Biotechnology and Bioengineering · doi:10.1002/bit.260320803 · Cited by 477 · see citing works
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
Hauser, D. N., & Hastings, T. G. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.011 · Cited by 470 · see citing works
Glutaminolysis as a target for cancer therapy
Jin, L., Alesi, G. N., & Kang, S. (2016) · Oncogene · doi:10.1038/onc.2015.447 · Cited by 459 · see citing works
Energy Metabolism of the Osteoblast: Implications for Osteoporosis
Lee, W.-C., Guntur, A. R., Long, F., & Rosen, C. J. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00064 · Cited by 443 · see citing works
Tommaso, L. D., Franchi, G., Park, Y. N., Fiamengo, B., Destro, A., Morenghi, E., Montorsi, M., Torzilli, G., Tommasini, M., Terracciano, L., et al. (2007) · Hepatology · doi:10.1002/hep.21531 · Cited by 425 · see citing works
Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation
Wang, F., Zhang, S., Vučković, I., Jeon, R., Lerman, A., Folmes, C. D. L., Dzeja, P. P., & Herrmann, J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.012 · Cited by 414 · see citing works
Moreadith, R. W., & Lehninger, A. L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82128-0 · Cited by 415 · see citing works
Perciavalle, R. M., Stewart, D. P., Koss, B. S., Lynch, J., Milasta, S., Bathina, M., Temirov, J. P., Harwig, M. C., Pelletier, S. W., Schuetz, J. D., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2488 · Cited by 407 · see citing works
Brand, K. A., & Hermfisse, U. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.5.9141507 · Cited by 401 · see citing works
Quiescent Fibroblasts Exhibit High Metabolic Activity
Lemons, J. M. S., Feng, X., Bennett, B. D., Legesse-Miller, A., Johnson, E. L., Raitman, I., Pollina, E. A., RABITZ, H. A., Rabinowitz, J. D., & Coller, H. A. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000514 · Cited by 377 · see citing works
Hung, V., Lam, S. S., Udeshi, N. D., Svinkina, T., Guzman, G., Mootha, V. K., Carr, S. A., & Ting, A. Y. (2017) · eLife · doi:10.7554/elife.24463 · Cited by 378 · see citing works
Jin, L., Li, D., Alesi, G. N., Fan, J., Kang, H., Zhou, L., Boggon, T. J., Jin, P., Yi, H. L., Wright, E., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.006 · Cited by 371 · see citing works
Targeting glucose metabolism for cancer therapy
Hamanaka, R. B., & Chandel, N. S. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120162 · Cited by 371 · see citing works
The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
Newsholme, E. A., Crabtree, B., & Ardawi, M. S. (1985) · Bioscience Reports · doi:10.1007/bf01116556 · Cited by 364 · see citing works
Gohil, V. M., Sheth, S., Nilsson, R., Wojtovich, A. P., Lee, J. H., Perocchi, F., Chen, W., Clish, C., Ayata, C., Brookes, P., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1606 · Cited by 191 · see citing works
Glacken, M. W., Fleischaker, R. J., & Sinskey, A. J. (1986) · Biotechnology and Bioengineering · doi:10.1002/bit.260280912 · Cited by 348 · see citing works
The importance of ammonia in mammalian cell culture
Schneider, M. (1996) · Journal of Biotechnology · doi:10.1016/0168-1656(95)00196-4 · Cited by 343 · see citing works
Zweibaum, A., Pinto, M., Chevalier, G., Dussaulx, E., Triadou, N., Lacroix, B. D., HAFFEN, K., Brun, J.-F., & Rousset, M. (1985) · Journal of Cellular Physiology · doi:10.1002/jcp.1041220105 · Cited by 341 · see citing works
MYC and metabolism on the path to cancer
Hsieh, A. L., Walton, Z. E., Altman, B. J., Stine, Z. E., & Dang, C. V. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.003 · Cited by 337 · see citing works
Souba, W. W., Klimberg, V. S., Plumley, D. A., Salloum, R. M., Flynn, T. C., Bland, K. I., & Copeland, E. M. (1990) · Journal of Surgical Research · doi:10.1016/0022-4804(90)90080-l · Cited by 334 · see citing works
Greiner, E. F., Guppy, M., & Brand, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31720-4 · Cited by 307 · see citing works
Dysregulated metabolism contributes to oncogenesis
Hirschey, M. D., DeBerardinis, R. J., Diehl, A. M., Drew, J. E., Frezza, C., Green, M. F., Jones, L. W., Ko, Y. H., Le, A., Lea, M. A., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.10.002 · Cited by 306 · see citing works
A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation
Arroyo, J. D., Jourdain, A. A., Calvo, S. E., Ballarano, C. A., Doench, J. G., Root, D. E., & Mootha, V. K. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.017 · Cited by 306 · see citing works
Stehle, G., Sinn, H., Wunder, A., Schrenk, H. H., Stewart, J. C. M., Hartung, G., Maier-Borst, W., & Heene, D. L. (1997) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(97)00015-2 · Cited by 305 · see citing works
Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism
Walsh, C. T., Tu, B. P., & Tang, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00510 · Cited by 302 · see citing works
Glycolysis, glutaminolysis and cell proliferation
McKeehan, W. L. (1982) · Cell Biology International Reports · doi:10.1016/0309-1651(82)90125-4 · Cited by 305 · see citing works
Wang, Y., & Bogenhagen, D. F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604501200 · Cited by 303 · see citing works
Souba, W. W. (1993) · Annals of Surgery · doi:10.1097/00000658-199312000-00004 · Cited by 294 · see citing works
Citrate – new functions for an old metabolite
Iacobazzi, V., & Infantino, V. (2014) · Biological Chemistry · doi:10.1515/hsz-2013-0271 · Cited by 285 · see citing works
Aguer, C., Gambarotta, D., Mailloux, R. J., Moffat, C., Dent, R., McPherson, R., & Harper, M.-E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028536 · Cited by 276 · see citing works
Secretion of pyruvate. An antioxidant defense of mammalian cells.
O’Donnell-Tormey, J., Nathan, C. F., Lanks, K. W., DeBoer, C. J., & de la Harpe, J. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.2.500 · Cited by 281 · see citing works
Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells
Saedeleer, C. J. D., Copetti, T., Porporato, P. E., Verrax, J., Féron, O., & Sonveaux, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046571 · Cited by 274 · see citing works
The Influence of Metabolism on Drug Response in Cancer
Zaal, E. A., & Berkers, C. R. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00500 · Cited by 272 · see citing works
Maintenance of Small Bowel Mucosa with Glutamine‐Enriched Parenteral Nutrition
O’Dwyer, S., Smith, R. J., Hwang, T. L., & Wilmore, D. W. (1989) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607189013006579 · Cited by 277 · see citing works
Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy
Guy, J. R., Qi, X., Pallotti, F., Schon, E. A., Manfredi, G., Carelli, V., Martinuzzi, A., Hauswirth, W. W., & Lewin, A. S. (2002) · Annals of Neurology · doi:10.1002/ana.10354 · Cited by 273 · see citing works
Deviant energetic metabolism of glycolytic cancer cells
Baggetto, L. G. (1992) · Biochimie · doi:10.1016/0300-9084(92)90016-8 · Cited by 268 · see citing works
Factors affecting cell growth and monoclonal antibody production in stirred reactors
Reuveny, S., Velez, D., Macmillan, J. D., & Miller, L. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90264-4 · Cited by 265 · see citing works
Growth inhibition in animal cell culture
Hassell, T., Gleave, S., & Butler, M. (1991) · Applied Biochemistry and Biotechnology · doi:10.1007/bf02922022 · Cited by 260 · see citing works
Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status
Melser, S., Chatelain, É. H., Lavie, J., Mahfouf, W., José, C., Obre, É., Goorden, S. M. I., Priault, M., Elgersma, Y., Rezvani, H. R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.014 · Cited by 259 · see citing works
Götz, A., Tyynismaa, H., Euro, L., Ellonen, P., Hyötyläinen, T., Ojala, T. H., Hämäläinen, R. H., Tommiska, J., Raivio, T., Orešič, M., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.04.006 · Cited by 257 · see citing works
Metabolic Regulation of Oocyte Cell Death through the CaMKII-Mediated Phosphorylation of Caspase-2
Nutt, L. K., Margolis, S. S., Jensen, M. V., Herman, C. E., Dunphy, W. G., Rathmell, J. C., & Kornbluth, S. A. (2005) · Cell · doi:10.1016/j.cell.2005.07.032 · Cited by 249 · see citing works
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
Ashton, T. M., Fokas, E., Kunz‐Schughart, L. A., Folkes, L. K., Anbalagan, S., Hüther, M., Kelly, M., Pirovano, G., Buffa, F. M., Hammond, E. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms12308 · Cited by 248 · see citing works
Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?
Dang, C. V. (2010) · Cell Cycle · doi:10.4161/cc.9.19.13302 · Cited by 245 · see citing works
Cancer metabolism: Key players in metabolic reprogramming
Soga, T. (2012) · Cancer Science · doi:10.1111/cas.12085 · Cited by 241 · see citing works
Ultrastructure of the Mitochondrion and Its Bearing on Function and Bioenergetics
Bénard, G., & Rossignol, R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.2000 · Cited by 240 · see citing works
Heterogeneity in Cancer Metabolism: New Concepts in an Old Field
Gentric, G., Mieulet, V., & Mechta‐Grigoriou, F. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6750 · Cited by 237 · see citing works
Spatial colocalization and functional link of purinosomes with mitochondria
French, J. B., Jones, S. A., Deng, H., Pedley, A. M., Kim, D., Chan, C. Y., Hu, H., Pugh, R. J., Zhao, H., Zhang, Y., et al. (2016) · Science · doi:10.1126/science.aac6054 · Cited by 241 · see citing works
Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611406113 · Cited by 234 · see citing works
Structure and Function of Malic Enzymes, A New Class of Oxidative Decarboxylases
Chang, G., & Tong, L. (2003) · Biochemistry · doi:10.1021/bi035251+ · Cited by 235 · see citing works
Delving deeper: MCL-1's contributions to normal and cancer biology
Perciavalle, R. M., & Opferman, J. T. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.011 · Cited by 233 · see citing works
Valcourt, J. R., Lemons, J. M. S., Haley, E. M., Kojima, M. L., Demuren, O. O., & Coller, H. A. (2012) · Cell Cycle · doi:10.4161/cc.19879 · Cited by 229 · see citing works
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells
Pérez-Escuredo, J., Dadhich, R. K., Dhup, S., Cacace, A., Van Hée, V. F., De Saedeleer, C. J., Sboarina, M., Rodriguez, F., Fontenille, M.-J., Brisson, L., et al. (2016) · Cell Cycle · doi:10.1080/15384101.2015.1120930 · Cited by 231 · see citing works
Cancer Metabolism: Current Understanding and Therapies
Counihan, J. L., Grossman, E. A., & Nomura, D. K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00775 · Cited by 229 · see citing works
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells
Smolková, K., Plecitá‐Hlavatá, L., Bellancé, N., Bénard, G., Rossignol, R., & Ježek, P. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.05.003 · Cited by 224 · see citing works
Laar, V. S. V., Arnold, B. A., Cassady, S. J., Chu, C. T., Burton, E. A., & Berman, S. B. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq531 · Cited by 221 · see citing works
mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer
de la Cruz-López, K. G., Toledo-Guzmán, M. E., Sánchez, E. O., & Carrancá, A. G. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01373 · Cited by 215 · see citing works
Cancer Cell MetabolismPreprint
Cairns, R. A., Harris, I. S., McCracken, S. A., & Mak, T. W. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.012856 · Cited by 223 · see citing works
Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
DeBerardinis, R. J. (2008) · Genetics in Medicine · doi:10.1097/gim.0b013e31818b0d9b · Cited by 217 · see citing works
- Authors
- Reitzer, L. J., Wice, B. M., & Kennell, D.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1979-04
- Volume
- 254
- Issue
- 8
- Pages
- 2669-2676
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1483212110
- Cited by
- 1,240
- References
- 39
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 30 · 2023: 40 · 2022: 24 · 2021: 45 · 2020: 31 · 2019: 28 · 2018: 42 · 2017: 42 · 2016: 38 · 2015: 38 · 2014: 48 · 2013: 36 · 2012: 46
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- glutamine, glucose, energy metabolism, HeLa cells, cultured cells, energy sources
- MeSH terms
- Adenosine Diphosphate, Adenosine Triphosphate, Citric Acid Cycle, Fructose, Galactose, Glucose, Glutamine, HeLa Cells, Humans, Kinetics, Lactates, Pentoses
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