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Cited by 322Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanismsMemory and Neural Mechanisms

The projection of the lateral geniculate nucleus to area 17 of the rat cerebral cortex. I. General description

Peters, Alan, Feldman, Martin L.·1976·Journal of Neurocytology
DOI 10.1007/bf01176183
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Abstract

Lesions were made in the lateral geniculate nucleus of the rat and the consequent degeneration in area 17 of the cerebral cortex was studied by light and electron microscopy. These lesions produced prominent degeneration of axon terminals in layer IV extending into layer III and a much lesser amount in layers I and VI. The darkened degenerating axon terminals forming asymmetric synaptic junctions and were frequently surrounded by hypertrophied astrocytic processes. These terminals appeared to be disposed randomly, forming no discernible patterns. In layer IV 83% of the synapsing, degenerating terminals formed junctions with dendritic spines, 15% with dendritic shafts, and 2% with neuronal perikarya. The dendritic shafts and neuronal perikarya appeared to belong to spine-free stellate cells. The dendrites giving rise to the spines receiving degenerating axon terminals could not be identified, for most of the spines appeared as isolated profiles that could not be traced back to their dendritic shafts. One example of a degenerating axon terminal synapsing with an axon initial segment was encountered. Small, degenerating myelinated axons were prevalent in layers VI, V and IV, but were only infrequent in the supragranular layers. These results are compared with those obtained in other studies of thalamocortical projections.

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Crossref · 10.1007/bf01176183

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  • Peters' rule holds that connectivity arises by chance from the geometric overlap of presynaptic axons and postsynaptic dendrites.

    “According to Peter’s rule connectivity would be established by chance, and would be a reflection of the statistical occurrence of presynaptic axonal terminals being closely apposed to potential postsynaptic targets as dictated by the geometrical distribution of axons and dendrites (Braitenberg and Schuz, 1991).”

    From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Peters and Feldman, 1976

  • Many exceptions to Peters' rule have been described, even when the rule was first proposed.

    “While examples that Peters’ rule (Peters and Feldman, 1976)is closely followed in the cortex exist, virtually as many exceptions have been described, even at the time that the rule was proposed (Braitenberg and Schuz, 1991).”

    From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Peters and Feldman, 1976

  • The estimation of synapse count from axo-dendritic apposition (Peters' rule) does not hold in systems where it has been directly measured.

    “The estimation of synapse count from axo-dendritic apposition, also known as “Peters’ rule” [36], has been shown not to hold in systems where it has been directly measured [37, 38].”

    From Synaptic counts approximate synaptic contact area in Drosophila (2022) · cites this paper as [36]

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Authors
Peters, A., & Feldman, M. L.
Affiliations
Boston University (US)
ORCID
Peters, Alan
Venue
Journal of Neurocytology
Publisher
Springer Science and Business Media LLC
Published
1976-02
Volume
5
Issue
1
Pages
63-84
ISSN
  • 0300-4864 (ISSN-L)
  • 1573-7381
DOI
10.1007/bf01176183
OpenAlex
W2006700032
Cited by
322
References
58
Citations by year
2026: 4 · 2025: 6 · 2024: 14 · 2023: 5 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 11 · 2013: 4 · 2012: 7
FWCI
5.00
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Neurocytology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
lateral geniculate nucleus, area 17, primary visual cortex, thalamocortical connections, axon terminal degeneration, dendritic spines, stellate cells, astrocyte hypertrophy, axon initial segment, myelinated axons, rats
MeSH terms
Animals, Astrocytes, Axons, Cerebral Cortex, Geniculate Bodies, Mitochondria, Nerve Degeneration, Nerve Fibers, Myelinated, Neurons, Synapses, Synaptic Membranes, Synaptic Vesicles, Rats

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