Toxikologie der synthetischen Antioxidantien BHA und BHT im Vergleich mit dem nat�rlichen Antioxidans Vitamin E

Chemoprevention of Cancer

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Down-Regulation of the Antitumor Immune Response

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Carcinogenicity of Butylated Hydroxyanisole in F344 Rats 234

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Studies on Antioxidants: Their Carcinogenic and Modifying Effects on Chemical Carcinogenesis

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Responses of the L5178Y tk+/tk− mouse lymphoma cell forward mutation assay ii: 18 coded chemicals

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THE MUTAGENIC ACTIVITY OF 61 AGENTS AS DETERMINED BY THE MICRONUCLEUS, SALMONELLA, AND SPERM ABNORMALITY ASSAYS

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The Role of Oxygen Radicals as a Possible Mechanism of Tumor Promotion

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Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of γ-glutamyl transpeptidase-positive foci development in the liver of rats

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Tolerance and safety of vitamin E: A toxicological position report

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Synthetic antioxidants: Biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens

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Pulmonary Fibrosis—A possible mechanism

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Free radicals in tumor promotion

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The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice

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Lung injury induced by butylated hydroxytoluene: cytodynamic and biochemical studies in mice.

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Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat

Peraino, C., Fry, R. J., Staffeldt, E. F., et al. (1977) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(77)80311-8 · Cited by 138

Dose-response study of hemorrhagic death by dietary butylated hydroxytoluene (BHT) in male rats

Takahashi, O., & Hiraga, K. (1978) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(78)90019-4 · Cited by 119

Toxicology of gallates: A review and evaluation

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Lung Damage in Mice Following Intraperitoneal Injection of Butylated Hydroxytoluene

Marino, A. A., & Mitchell, J. (1972) · Experimental Biology and Medicine · doi:10.3181/00379727-140-36407 · Cited by 110

Inhibitory effect of butylated hydroxytoluene (BHT) on intestinal carcinogenesis in rats by azoxymethane

Weisburger, E. K., Evarts, R. P., & Wenk, M. L. (1977) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(77)80320-9 · Cited by 93

Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT)

Witschi, H. R., Malkinson, A. M., & Thompson, J. A. (1989) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(89)90023-5 · Cited by 91

Carcinogenicity study on butylated hydroxytoluene (BHT) in Wistar rats exposed in utero

Olsen, P., Meyer, O., Bille, N., & Würtzen, G. (1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90256-5 · Cited by 89

Contact dermatitis from antioxidants.

Roed‐Petersen, J., & HJORTH, N. (1976) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1976.tb04379.x · Cited by 89

On the mechanism of butylated hydroxytoluene-induced hepatic toxicity in rats

Nakagawa, Y., Tayama, K., Nakao, T., & Hiraga, K. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90643-9 · Cited by 88

Chronic toxicity of butylated hydroxytoluene in Wistar rats

Hirose, M., Shibata, M., Hagiwara, A., Imaida, K., & Ito, N. (1981) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(81)90350-3 · Cited by 78

THE EFFECT OF THE LEVEL OF DIETARY FAT ON THE TOXICITY OF PHENOLIC ANTIOXIDANTS

Brown, W., Johnson, A., & O'Halloran, M. W. (1959) · Immunology and Cell Biology · doi:10.1038/icb.1959.56 · Cited by 73

Histopathological and radioautographical studies on the forestomach of F344 rats treated with butylated hydroxyanisole and related chemicals

Clayson, D. B., Iverson, F., Nera, E. A., Lok, E., Rogers, C. G., Rodrigues, C., Page, D. B., & Karpinski, K. (1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90305-4 · Cited by 67

Hepatic responses to the administration of high doses of BHT to the rat: Their relevance to hepatocarcinogenicity

Powell, C. J., Connelly, J. C., Jones, S. M., GRASSO, P., & Bridges, J. W. (1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90299-1 · Cited by 63

Ultrastructural and biochemical changes in the liver of monkeys given butylated hydroxytoluene and butylated hydroxyanisole

Allen, J., & Engblom, J. (1972) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(72)80003-8 · Cited by 59

d-.alpha.-Tocopheryl poly(ethylene glycol) 1000 succinate: acute toxicity, subchronic feeding, reproduction, and teratologic studies in the rat

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Hepatocellular Tumorigenicity of Butylated Hydroxytoluene Administered Orally to B6C3F1 Mice

Inai, K., Kobuke, T., Nambu, S., Takemoto, T., Kou, E., Nishina, H., Fujihara, M., Yonehara, S., Suehiro, S., Tsuya, T., et al. (1988) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1988.tb00010.x · Cited by 57

BHA study in pigs

Würtzen, G., & Olsen, P. (1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90311-x · Cited by 56

Different modifying response of butylated hydroxyanisole, butylated hydroxytoluene, and other antioxidants in N,N-dibutylnitrosamine esophagus and forestomach carcinogenesis of rats.

Fukushima, S., Sakata, T., Tagawa, Y., et al. (1987) · PubMed · Cited by 54

Toxicity of butylated hydroxytoluene in mouse following oral administration

Witschi, H. R., & Lock, S. (1978) · Toxicology · doi:10.1016/0300-483x(78)90038-0 · Cited by 53

Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats

Maeura, Y., & Williams, G. M. (1984) · Food and Chemical Toxicology · doi:10.1016/0278-6915(84)90126-1 · Cited by 53

Lack of carcinogenicity of butylated hydroxytoluene on long-term administration to b6c3f1 mice

Shirai, T., Hagiwara, A., Kurata, Y., Shibata, M., Fukushima, S., & Ito, N. (1982) · Food and Chemical Toxicology · doi:10.1016/s0015-6264(82)80219-8 · Cited by 52

Effect of butylated hydroxytoluene and other antioxidants on mouse lung metabolism

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Thirteen-week toxicity study of d-α-tocopheryl acetate (vitamin E) in Fischer 344 rats

Abdo, K. M., Rao, G. N., Montgomery, C. A., Dinowitz, M., & KANAGALINGAM, K. K. (1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90287-5 · Cited by 50

The effect of butylated hydroxyanisole and butylated hydroxytoluene on behavioral development of mice

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Absence of teratogenic effect of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) in rats and mice

Clegg, D. J. (1965) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(65)80127-4 · Cited by 47

Effects of low levels of butylated hydroxytoluene on the prothrombin index of male rats

Takahashi, O., & Hiraga, K. (1978) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(78)80262-4 · Cited by 45

Inhibition of Chemically Induced Mammary Carcinogenesis in Rats by Long-Term Exposure to Butylated Hydroxytoluene (BHT): Interrelations Among BHT Concentration, Carcinogen Dose, and Diet234

Cohen, L. A., Choi, K., Numoto, S., Reddy, M., Berke, B., & Weisburger, J. H. (1986) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/76.4.721 · Cited by 43

Tests for mutagenic effects of ammoniated glycyrrhizin, butylated hydroxytoluene, and gum arabic in rodent germ cells

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Effects of butylated hydroxytoluene alone or with diethylnitrosamine in mice

Clapp, N. K., Tyndall, R. L., Cumming, R. B., & Otten, J. A. (1974) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(74)90009-1 · Cited by 41

Intake of phenolic antioxidants from foods in Canada

Kirkpatrick, D. C., & Lauer, B. (1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90285-1 · Cited by 41

Butylated hydroxyanisole, butylated hydroxytoluene and tert-butylhydroquinone are not mutagenic in the Salmonella/microsome assay using new tester strains

Hageman, G. J., Verhagen, H., & Kleinjans, J. C. S. (1988) · Mutation Research Letters · doi:10.1016/0165-7992(88)90062-0 · Cited by 39

Effect of large amounts of vitamin E during pregnancy and lactation

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A metabolite of butylated hydroxytoluene with potent tumor-promoting activity in mouse lung

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The acute toxicity of butylated hydroxytoluene and its metabolites in mice

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Cytotoxicity of butylated hydroxytoluene and butylated hydroxyanisole in cultured heart cells

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Inhibition of Chemically Induced Mammary Carcinogenesis in Rats by Short-Term Exposure to Butylated Hydroxytoluene (BHT): Interrelationships Among BHT Concentration, Carcinogen Dose, and Diet234

Cohen, L. A., Polansky, M., Furuya, K., Reddy, M., Berke, B., & Weisburger, J. H. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/72.1.165 · Cited by 34

Effect of High Levels of Dietary Vitamin E on Hematological Indices and Biochemical Parameters in Rats

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Evidence for a role of tert-butyl hydroxylation in the induction of pneumotoxicity in mice by butylated hydroxytoluene

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Adenoma Development in Mouse Lung Following Treatment with Possible Promoting Agents

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Developmental neurobehavioural toxicity of butylated hydroxytoluene in rats

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Vitamin K deficiency in male rats fed diets containing butylated hydroxytoluene (BHT)

Suzuki, H., Nakao, T., & Hiraga, K. (1979) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(79)90151-0 · Cited by 30

Biochemical effects of two promoters of hepatocarcinogenesis in rats

Kitchin, K. T., & Brown, J. L. (1987) · Food and Chemical Toxicology · doi:10.1016/0278-6915(87)90021-4 · Cited by 29

Species differences in the haemorrhagic response to butylated hydroxytoluene

Takahashi, O., Hayashida, S., & Hiraga, K. (1980) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(80)90099-1 · Cited by 28

Effects of butylated hydroxyanisole on the tumorigenicity and metabolism of N-nitrosodimethylamine and N-nitrosopyrrolidine in A/J mice.

Chung, F., Wang, M., Carmella, S. G., et al. (1986) · PubMed · Cited by 28

Levels of BHA and BHT in human and animal adipose tissue: Interspecies extrapolation

Conacher, H. B. S., Iverson, F., Lau, P. ‐., & Page, B. D. (1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90302-9 · Cited by 27

Hyperplasia of hepatic bile ducts in mice following long-term administration of butylated hydroxytoluene

Clapp, N. K., Tyndall, R. L., & Cumming, R. B. (1973) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(73)90143-0 · Cited by 27

Long-Term Antioxidant Exposure Effects on Female Primates

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Modification of butylated hydroxytoluene-induced pulmonary toxicity in mice by diethyl maleate, buthionine sulfoximine, and cysteine

Mizutani, T., NOMURA, H., Yamamoto, K., & Tajima, K. (1984) · Toxicology Letters · doi:10.1016/0378-4274(84)90029-8 · Cited by 24

Regression of simple hyperplasia and papillomas and persistence of basal cell hyperplasia in the forestomach of F344 rats treated with butylated hydroxyanisole.

Masui, T., Asamoto, M., Hirose, M., et al. (1987) · PubMed · Cited by 22

Strain differences in butylated hydroxytoluene-induced deaths in male mice

Kawano, S. (1981) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(81)90371-9 · Cited by 21

Initiating potential of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and 3,3′,4′,5,7-pentahydroxyflavone (quercetin) in two-stage mouse skin carcinogenesis

Sato, H., Takahashi, M., Furukawa, F., Miyakawa, Y., Hasegawa, R., Toyoda, K., & Hayashi, Y. (1987) · Cancer Letters · doi:10.1016/0304-3835(87)90199-6 · Cited by 20

VITAMIN E: TERATOGEN OR ANTI-TERATOGEN?

Hook, E. B., Healy, K. M., Niles, A. M., & Skalko, R. G. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92878-5 · Cited by 20

Butylated Hydroxytoluene as a Skin Lightener

Bentley-Phillips, B. (1974) · Archives of Dermatology · doi:10.1001/archderm.1974.01630020032007 · Cited by 19

Modifying effects of concomitant treatment with butylated hydroxyanisole or butylated hydroxytoluene on N,N-dibutylnitrosamine-induced liver, forestomach and urinary bladder carcinogenesis in F344 male rats

Imaida, K., Fukushima, S., Inoue, K., Masui, T., Hirose, M., & Ito, N. (1988) · Cancer Letters · doi:10.1016/0304-3835(88)90166-8 · Cited by 18

The effect of butylated hydroxytoluene (BHT) on the rat thyroid

Søndergaard, D., & Olsen, P. (1982) · Toxicology Letters · doi:10.1016/0378-4274(82)90081-9 · Cited by 18

2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone (BHT quinone methide): an active metabolite of BHT causing haemorrhages in rats

Takahashi, O. (1988) · Archives of Toxicology · doi:10.1007/bf00332495 · Cited by 17

Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus

Park, E., Chang, H., & Cha, Y. (1990) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1990.tb02638.x · Cited by 17

Inhibitory actions of butylated hydroxytoluene on isolated ileal, atrial, and perfused heart preparations

Gad, S. C., Leslie, S. W., & Acosta, D. (1979) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(79)90275-8 · Cited by 16

Effects of dietary butylated hydroxytoluene on functional and biochemical properties of platelets and plasma preceding the occurrence of haemorrhage in rats

Takahashi, O., & Hiraga, K. (1984) · Food and Chemical Toxicology · doi:10.1016/0278-6915(84)90087-5 · Cited by 15

Modification of gastrointestinal tumor development in rats by dietary butylated hydroxytoluene*1

Lindenschmidt, R. C. (1987) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(87)90133-3 · Cited by 14

Decrease in blood coagulation factors II (prothrombin), VII, IX and X in the rat after a single oral dose of butylated hydroxytoluene

Takahashi, O. (1987) · Food and Chemical Toxicology · doi:10.1016/0278-6915(87)90085-8 · Cited by 13

Effect of Subacute Oral Intake of the Food Antioxidant Butylated Hydroxyanisole on Clinical Parameters and Phase-I and -II Biotransformation Capacity in Man

Verhagen, H., Maas, L. M., Beckers, R. H. G., Thijssen, H. H. W., ten Hoor, F., Henderson, P. T., & Kleinjans, J. C. S. (1989) · Human Toxicology · doi:10.1177/096032718900800604 · Cited by 12

Effect of butylated hydroxytoluene on the lipid composition of rat liver

Takahashi, O., & Hiraga, K. (1981) · Toxicology · doi:10.1016/0300-483x(81)90115-3 · Cited by 12

Vitamin K content of liver and feces from vitamin K-deficient and butylated hydroxytoluene (BHT)-treated male rats

Suzuki, H., Nakao, T., & Hiraga, K. (1983) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(83)90253-3 · Cited by 7

Plant Polyphenols as Antioxidant and Antibacterial Agents for Shelf‐Life Extension of Meat and Meat Products: Classification, Structures, Sources, and Action Mechanisms

Papuc, C., Goran, G. V., Predescu, C. N., Nicorescu, V., & Stefan, G. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12298 · Cited by 561

In vitro antioxidant properties of crude extracts and compounds from brown algae

Balboa, E. M., Conde, E., Moure, A., Falqué, E., & Domínguez, H. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2012.11.026 · Cited by 436

Potential pharmacological applications of polyphenolic derivatives from marine brown algae

Thomas, N. V., & Kim, S.-K. (2011) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2011.09.004 · Cited by 269

Lactobacillus-produced exopolysaccharides and their potential health benefits: A review

Patten, D. A., & Laws, A. P. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0117 · Cited by 100