The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice
Abstract
Male and female C3H mice were fed a diet containing 0.5% or 0.05% of the antioxidant butylated hydroxytoluene (BHT). After 10 months, male but not female animals had a significantly increased incidence of liver tumors compared to animals kept on a BHT-free control diet. In a second experiment, male BALB/c mice were treated subcutaneously with the carcinogens dimethylhydrazine (DMH) or intrarectally with methylnitrosourea (MNU). A diet containing 0.5% BHT significantly increased the incidence of colon tumors in DMH treated animals but had no effect in mice given MNU. It is concluded that the effect of BHT on tumor development depends on strain and target organ examined and possibly also on the chemical carcinogen used.
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Synthetic compounds such as BHA or BHT are suspected to have harmful effects on human health, and their use is discouraged.
“These synthetic compounds are, however, suspected to have harmful effects on human health, and their use is therefore discouraged [9, 10].”
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“,ese synthetic compounds are, however, suspected to have harmful effects on human health, and their use is therefore discouraged [9, 10].”
BackgroundChia, Quinoa, and Their Coproducts as Potential Antioxidants for the Meat Industry
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- Authors
- Lindenschmidt, R. C., Tryka, A. F., Goad, M. E., & Witschi, H. P.
- Affiliations
- Oak Ridge National Laboratory (US)
- Venue
- Toxicology
- Publisher
- Elsevier BV
- Published
- 1986-02
- Volume
- 38
- Issue
- 2
- Pages
- 151-160
- ISSN
- 0300-483X (ISSN-L)
- OpenAlex
- W2023944033
- Cited by
- 185
- References
- 23
- Citations by year
- 2026: 1 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 4 · 2013: 11 · 2012: 11
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- butylated hydroxytoluene, dietary antioxidants, liver tumors, colon cancer, carcinogenesis, dimethylhydrazine, N-methyl-N-nitrosourea, sex differences, strain differences, tumor incidence, C3H mice, BALB/c mice
- MeSH terms
- Animals, Body Weight, Butylated Hydroxytoluene, Carcinogens, Colonic Neoplasms, Diet, Dimethylhydrazines, Female, Gastrointestinal Neoplasms, Liver Neoplasms, Male, Methylnitrosourea, Mice, Inbred BALB C, Mice, Inbred C3H, Neoplasms, Multiple Primary, Time Factors, 1,2-Dimethylhydrazine, Mice
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