Immediate effect of lesion of the ventromedial hypothalamic area upon glucose-induced insulin secretion in anaesthetized rats
Open accessAbstract
Insulin secretion, measured in vivo following an intravneous load of glucose to anaesthetized rats, was markedly increased ten minutes after bilateral electrolytic lesions of the ventromedial hypothalamic (VMH) area when compared to both sham-operated and unoperated controls. The successful lesioning of the VMH area was assessed by the subsequent occurrence of hyperphagia, as estimated by the increase in body weight. It is concluded that the ventromedial hypothalamic area exerts an inhibitory influence upon the secretory activity of the B-cells. Furthermore, the rapid disappearance of such inhibitory influence following lesions of the VMH suggests that this area of the brain may be of importance in the minute to minute regulation of insulin secretion. The precise anatomical location of the hypothalamic "nucleus" (or "nuclei") involved, as well as the neural or humoral nature of its inhibitory effect upon the endocrine pancreas remain to be elucidated.
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Destruction of the ventromedial hypothalamus results in insulin hypersecretion due to loss of the ventromedial hypothalamus-mediated inhibitory impact on pancreatic β-cells and also in higher glucagon levels.
“The destruction of the ventromedial hypothalamus results not only in insulin hypersecretion110, 111, 112 due to loss of the ventromedial hypothalamus-mediated inhibitory impact on pancreatic β-cells113 but also in higher glucagon levels.111, 112”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [113]
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- Authors
- Rohner, F., Dufour, A. C., Karakash, C., Le Marchand, Y., Ruf, K. B., & Jeanrenaud, B.
- Affiliations
- University of Geneva (CH)
- Venue
- Diabetologia
- Published
- 1977-05
- Volume
- 13
- Issue
- 3
- Pages
- 239-242
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2047242212
- Cited by
- 61
- References
- 20
- Citations by year
- 2024: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2012: 3
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- ventromedial hypothalamus, insulin secretion, glucose-induced insulin release, hypothalamic lesions, hyperphagia, body weight
- MeSH terms
- Insulin Secretion, Animals, Female, Glucose, Hypothalamus, Hypothalamus, Middle, Insulin, Rats
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