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Cited by 80Pancreatic function and diabetesRegulation of Appetite and ObesityNeuropeptides and Animal Physiology

Consequences of Ventromedial Hypothalamic Lesions upon Insulin and Glucagon Secretion by Subsequently Isolated Perfused Pancreases in the Rat

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Rohner-Jeanrenaud, Françoise, Jeanrenaud, Bernard·1980·Journal of Clinical Investigation
DOI 10.1172/jci109744PMC PMC434479
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Abstract

The existence of a relationship between the ventromedial hypothalamic area (VMH) and the activity of the endocrine pancreas has been shown previously. This relationship has been further tested and extended in the present study, using isolated perfused pancreases from rats previously lesioned (4-7 d) in the VMH. It was found that in isolated pancreases obtained from rats fed ad lib. for 4 d after VMH lesions (i.e., that were hyperphagic), the typical biphasic pattern of insulin secretion was observed following glucose stimulation (20 mM) and that the total insulin output was much greater than that of controls. The increased insulin output was not a result of hyperphagia because similar results were obtained using pancreases obtained from VMH-lesioned rats in which a food restriction matching exactly that of control rats was started either immediately of 3 d after the lesions. Pancreases from such food-restricted VMH-lesioned rats oversecreted insulin, when compared with controls fed the same amount, from 7 mM of glucose concentration in perfusion medium onwards. After the addition of arginine (10 mM), the total output of glucagon by pancreases from food-restricted VMH-lesioned rats was twice that of controls. Qualitatively, the arginine-induced glucagon secretion by pancreases from food-restricted VMH-lesioned rats retained its biphasic pattern. Similarly, epinephrine (0.1 muM) elicited a greater glucagon release by pancreases from food-restricted VMH-lesioned rats when compared with controls. These data further support the concept of a link (as yet undefined) between the hypothalamus and the endocrine pancreas, as lesions of the VMH area resulted in abnormal secretion not only of insulin, but of glucagon as well.

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  • Destruction of the ventromedial hypothalamus results in insulin hypersecretion due to loss of the ventromedial hypothalamus-mediated inhibitory impact on pancreatic β-cells and also in higher glucagon levels.

    “The destruction of the ventromedial hypothalamus results not only in insulin hypersecretion110, 111, 112 due to loss of the ventromedial hypothalamus-mediated inhibitory impact on pancreatic β-cells113 but also in higher glucagon levels.111, 112”

    From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [111]

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Research works printed but not linked: 2

  1. Karakash, C., F. Rohner, B. E. Hustvedt, and B. Jeanrenaud. 1979. Possible etiology of reduced nitrogen retention in hypothalamic obese rats. Amrl. J. Physiol. In press.
  2. Bemt, E., and H. U. Bergmeyer. 1963. In Methods of Enzymatic Analysis. H. U. Bergmeyer, Editor. Academic Press, Inc., New York. 401-406.

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Authors
Rohner-Jeanrenaud, F., & Jeanrenaud, B.
Affiliations
University of Geneva (CH)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1980-04-01
Volume
65
Issue
4
Pages
902-910
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci109744
PMC
PMC434479
OpenAlex
W2058015922
Cited by
80
References
39
Citations by year
2022: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1
FWCI
15.64
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
ventromedial hypothalamus, hypothalamic lesions, insulin secretion, glucagon secretion, isolated perfused pancreas, hyperphagia, dietary restriction, glucose-stimulated insulin secretion, L-arginine, epinephrine, endocrine pancreas
MeSH terms
Insulin Secretion, Animals, Feeding Behavior, Female, Food Deprivation, Glucagon, Hypothalamus, Insulin, Islets of Langerhans, Perfusion, Stereotaxic Techniques, Rats

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