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Cited by 68Herpesvirus Infections and TreatmentsAnimal Virus Infections StudiesVirology and Viral Diseases

Equine herpesvirus type 1 (EHV-1) induced abortions and paralysis in a Lipizzaner stud: a contribution to the classification of equine herpesviruses

Chowdhury, S. I., Kubin, G., Ludwig, H.·1986·Archives of Virology
DOI 10.1007/bf01317376
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Abstract

Out of 30 cases of abortion and perinatal deaths in a Lipizzaner stud in Austria 10 mares died after having shown central nervous system disturbances, ataxias and paralysis. The etiological agent of this "abortion storm" was equine herpesvirus type 1 (EHV-1). The restriction enzyme pattern of the DNA from 5 isolates recovered from fetuses has been analyzed and compared with the known reference strains of EHV-1, -2, -4 and an Austrian vaccine strain. The DNA restriction profiles of the Lipizzaner isolates as well as of the vaccine strain could be identified as being typical of abortigenic strains with minor variations. Such variations on the molecular biological level of the DNA do not justify characterization of the strains as neuro-variants. The vaccine strain differed from other isolates investigated with 4 restriction endonucleases (Bam HI, Bgl II, EcoRI, Kpn I) which was due to a deletion in the unique short segment of the genome. The lack of similar DNA bands in two EHV-1 viruses, causing mild respiratory disease, as well as in the vaccine strain Prevaccinol is suggestive of lowered virulence. In contrast to one Lipizzaner isolate tested (strain Austria IV) the Austrian vaccine strain proved to be of strong neurovirulence for suckling mice.

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Crossref · 10.1007/bf01317376

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  • EHV-1 infects PBMC and is transferred to endothelial cells via cell-associated viremia, causing severe outcomes including abortion, perinatal mortality, neurological disorders, and death.

    “Equine herpesvirus type 1 (EHV-1) is another example of herpesviruses infecting PBMC and then being transferred to EC via cell-associated viremia causing severe outcomes including abortion, perinatal mortality, neurological disorders, and death (Chowdhury et al., 1986; Van Maanen, 2002).”

    From Equid Herpesvirus-1 Exploits the Extracellular Matrix of Mononuclear Cells to Ensure Transport to Target Cells (2020) · cites this paper as Chowdhury et al., 1986

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Related

Authors
Chowdhury, S. I., Kubin, G., & Ludwig, H.
Affiliations
Robert Koch Institute (DE)
ORCID
Chowdhury, S. I.
Venue
Archives of Virology
Publisher
Springer Science and Business Media LLC
Published
1986-09
Volume
90
Issue
3-4
Pages
273-288
ISSN
  • 0003-9012 (ISSN-L)
  • 0304-8608
  • 1432-8798
DOI
10.1007/bf01317376
OpenAlex
W1965105041
Cited by
68
References
44
Citations by year
2022: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 1
FWCI
4.45
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Archives of Virology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
equine herpesvirus 1, abortion (veterinary), paralysis, Lipizzaner horses, restriction endonuclease patterns, equine herpesvirus 2, equine herpesvirus 4, vaccine strain, neurovirulence, ataxia, perinatal death
MeSH terms
Abortion, Veterinary, Animals, Chromosome Mapping, DNA Restriction Enzymes, DNA, Viral, Female, Herpesviridae, Horse Diseases, Horses, Male, Neurons, Paralysis, Pregnancy, Viral Vaccines

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