Paralysis of Horses Associated with Equine Herpesvirus 1 Infection

Jackson, Terry; Kendrick, John W.

doi:10.2460/javma.1971.158.08.1351

Cited by 65Herpesvirus Infections and TreatmentsAnimal Virus Infections StudiesVeterinary Equine Medical Research

Paralysis of Horses Associated with Equine Herpesvirus 1 Infection

Jackson, Terry, Kendrick, John W.·1971·Journal of the American Veterinary Medical Association

DOI 10.2460/javma.1971.158.08.1351

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Abstract

SUMMARY: Paralysis in association with epizootics of abortion and respiratory disease due to equine herpesvirus 1 infection (equine rhinopneumonitis) has been reported in Europe and the United States. Of 7 pregnant mares inoculated with equine herpesvirus 1, 6 became paralyzed approximately 7 days after inoculation. Clinical signs ranged from mild ataxia followed by recovery, to severe paralysis and enforced recumbency. Five mares were euthanatized or died, and were necropsied. Vascular-oriented inflammation was the principal lesion, and this was especially prominent in the nervous system, where degenerative changes were observed. Virus was not isolated from any of the mares but was isolated from 2 of the fetuses.

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Lack of nutrients and oxygen and elevated levels of inflammatory cytokines cause neurons to degenerate, eventually leading to equine herpes myeloencephalopathy.
“The lack of nutrients and oxygen and the elevated levels of inflammatory cytokines cause neurons to degenerate, eventually leading to equine herpes myeloencephalopathy (EHM) (Jackson and Kendrick, 1971; Wilson, 1997).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Jackson and Kendrick, 1971

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Authors: Jackson, T., & Kendrick, J. W.
Affiliations: University of California, Davis (US)
Venue: Journal of the American Veterinary Medical Association
Publisher: American Veterinary Medical Association (AVMA)
Published: 1971-04-15
Volume: 158
Issue: 8
Pages: 1351-1357
ISSN: 0003-1488 (ISSN-L)
DOI: 10.2460/javma.1971.158.08.1351
OpenAlex: W2417334744
Cited by: 65
References: 0
Citations by year: 2024: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 2
FWCI: 1.49
Type: journal article
Language: en
Open access: closed
Locations: Journal of the American Veterinary Medical Association (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Veterinary › Equine › Veterinary Equine Medical Research
Keywords: equine herpesvirus 1, equine rhinopneumonitis, paralysis, horses, pregnant mares, abortion (veterinary), ataxia, neurodegeneration, vascular inflammation, fetal infection, epizootic
MeSH terms: Abortion, Veterinary, Animals, Central Nervous System Diseases, Female, Fetal Diseases, Herpesviridae, Herpesviridae Infections, Horse Diseases, Horses, Neutralization Tests, Paralysis, Pregnancy, Pregnancy, Animal

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Paralysis of Horses Associated with Equine Herpesvirus 1 Infection

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