Cited by 279Drug Transport and Resistance MechanismsFungal and yeast genetics researchBacterial Genetics and Biotechnology

Yeast multidrug resistance: The PDR network

Balzi, Elisabetta, Goffeau, André·1995·Journal of Bioenergetics and Biomembranes

Abstract

This minireview describes a network of genes involved in multiple drug resistance of the yeast S. cerevisiae. The transcription regulators, PDR1, PDR3, PDR7, and PDR9 control the expression of the gene PDR5, encoding a membrane protein of the ATP-binding-cassette superfamily and functioning as a drug extrusion pump. Next to PDR5, several other target genes, encoding membrane pumps of the ABC type, such as SNQ2, STE6, PDR10, PDR11, YOR1, but also other membrane-associated (such as GAS1, D4405) or soluble proteins (such as G3PD), involved or not in multidrug resistance, are found to be controlled by PDR1. On another side, the PDR3 regulator participates with its homolog PDR1 to co- and auto-regulation circuits of yeast multidrug resistance.

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Crossref · 10.1007/bf02110333

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Authors
Balzi, E., & Goffeau, A.
Affiliations
UCLouvain (BE)
Venue
Journal of Bioenergetics and Biomembranes
Published
1995-02
Volume
27
Issue
1
Pages
71-76
ISSN
  • 0145-479X (ISSN-L)
  • 1573-6881
OpenAlex
W1992927522
Cited by
279
References
30
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 10 · 2013: 4 · 2012: 10
FWCI
1.90
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Bioenergetics and Biomembranes (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
multidrug resistance, Saccharomyces cerevisiae, PDR1, PDR3, PDR5, ABC transporters, drug efflux pumps, transcriptional regulation, gene regulatory networks, SNQ2, Ste6, GAS1, autoregulation
MeSH terms
Chromosome Mapping, Cloning, Molecular, DNA-Binding Proteins, Genes, Fungal, Saccharomyces cerevisiae, Transcription Factors, Trans-Activators, Chromosomes, Fungal, Gene Expression Regulation, Fungal, Drug Resistance, Multiple, Saccharomyces cerevisiae Proteins

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