Yeast multidrug resistance: The PDR network
Abstract
This minireview describes a network of genes involved in multiple drug resistance of the yeast S. cerevisiae. The transcription regulators, PDR1, PDR3, PDR7, and PDR9 control the expression of the gene PDR5, encoding a membrane protein of the ATP-binding-cassette superfamily and functioning as a drug extrusion pump. Next to PDR5, several other target genes, encoding membrane pumps of the ABC type, such as SNQ2, STE6, PDR10, PDR11, YOR1, but also other membrane-associated (such as GAS1, D4405) or soluble proteins (such as G3PD), involved or not in multidrug resistance, are found to be controlled by PDR1. On another side, the PDR3 regulator participates with its homolog PDR1 to co- and auto-regulation circuits of yeast multidrug resistance.
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The Pleiotropic Drug Resistance (PDR) network is central to the drug response in fungi.
“The Pleiotropic Drug Resistance (PDR) network is central to the drug response in fungi, and its overactivation is associated with drug resistance.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [5]
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- Authors
- Balzi, E., & Goffeau, A.
- Affiliations
- UCLouvain (BE)
- Venue
- Journal of Bioenergetics and Biomembranes
- Published
- 1995-02
- Volume
- 27
- Issue
- 1
- Pages
- 71-76
- ISSN
- 0145-479X (ISSN-L)
- 1573-6881
- OpenAlex
- W1992927522
- Cited by
- 279
- References
- 30
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 10 · 2013: 4 · 2012: 10
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Bioenergetics and Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- multidrug resistance, Saccharomyces cerevisiae, PDR1, PDR3, PDR5, ABC transporters, drug efflux pumps, transcriptional regulation, gene regulatory networks, SNQ2, Ste6, GAS1, autoregulation
- MeSH terms
- Chromosome Mapping, Cloning, Molecular, DNA-Binding Proteins, Genes, Fungal, Saccharomyces cerevisiae, Transcription Factors, Trans-Activators, Chromosomes, Fungal, Gene Expression Regulation, Fungal, Drug Resistance, Multiple, Saccharomyces cerevisiae Proteins
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