Cited by 221Drug Transport and Resistance MechanismsFungal and yeast genetics researchAntifungal resistance and susceptibility

Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance

Prasad, Rajendra, Goffeau, Andre·2012·Annual Review of Microbiology

Abstract

Overexpression of the ATP-binding cassette (ABC) drug transporter P-glycoprotein (P-gp) is often responsible for the failure of chemotherapy as a treatment for human tumors. The presence of proteins homologous to P-gp in organisms ranging from prokaryotes to eukaryotes indicates that drug export is a general mechanism of multidrug resistance. Yeasts are no exception. They have developed a large subfamily of ABC exporters involved in pleiotropic drug resistance (PDR) and in the cellular efflux of a wide variety of drugs. The PDR transporters Pdr5p of Saccharomyces cerevisiae and Cdr1p of Candida albicans are important members of this PDR subfamily, which comprises up to 10 phylogenetic clusters in fungi. Here, we review current achievements concerning the structure, molecular mechanism, and physiological functions of yeast Pdr transporters.

Integrity signals

Registry

Crossref · 10.1146/annurev-micro-092611-150111

Cites

111 of 111 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Prasad, R., & Goffeau, A.
Affiliations
  • Jawaharlal Nehru University (IN)
  • Institut des Sciences de la Vie, Université Catholique de Louvain, Louvain-la-Neuve, 1349 Belgium;
Venue
Annual Review of Microbiology
Published
2012-10-13
Volume
66
Issue
1
Pages
39-63
ISSN
  • 0066-4227 (ISSN-L)
  • 1545-3251
OpenAlex
W2101491044
Cited by
221
References
111
Citations by year
2026: 4 · 2025: 10 · 2024: 17 · 2023: 11 · 2022: 8 · 2021: 16 · 2020: 20 · 2019: 18 · 2018: 12 · 2017: 17 · 2016: 25 · 2015: 21 · 2014: 18 · 2013: 20 · 2012: 4
FWCI
2.08
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • DIAL (Catholic University of Leuven) (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords
ABC transporters, multidrug resistance, pleiotropic drug resistance, Pdr5p, Cdr1p, Saccharomyces cerevisiae, Candida albicans, drug efflux, ABC exporters
MeSH terms
Antifungal Agents, Candida albicans, Fungal Proteins, Humans, Saccharomyces cerevisiae, ATP-Binding Cassette Transporters, Drug Resistance, Multiple, Fungal, Membrane Transport Proteins, Saccharomyces cerevisiae Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review