Candida tropicalis arthritis in a patient with acute myeloid leukemia successfully treated with fluconazole: Case report and review of the literature
Abstract
The case of a 77-year-old woman with acute myeloid leukemia who developed Candida tropicalis septic arthritis of the knee after remission-inducing chemotherapy is reported. A literature review of C. tropicalis non-prosthetic arthritis is included. The isolate was susceptible to fluconazole (MIC 0.25 mg/l). She was treated with fluconazole (400 mg orally) and frequent relieving synovial aspirations. After 1 month of antifungal therapy the synovial fluid became culture negative. Fluconazole concentration in the synovial fluid and serum were 20 mg/l and 19.4 mg/l, respectively. The patient was treated for a total of 7 months and made a full recovery. This is the first report of the successful use of fluconazole in the treatment of septic arthritis due to C. tropicalis.
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Adequate drainage is critical to successful therapy for Candida arthritis.
“Adequate drainage is critical to successful therapy [194].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [194]
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- Authors
- Weers-Pothoff, G., Havermans, J. F., Kamphuis, J., Sinnige, H. A. M., & Meis, J. F. G. M.
- Affiliations
- Robert Bosch (Netherlands) (NL)
- ORCID
- Meis, J. F. G. M.
- Venue
- Infection
- Published
- 1997-03
- Volume
- 25
- Issue
- 2
- Pages
- 109-111
- ISSN
- 0300-8126 (ISSN-L)
- 1439-0973
- OpenAlex
- W2040695137
- Cited by
- 27
- References
- 25
- Citations by year
- 2022: 1 · 2021: 1 · 2015: 2 · 2014: 1 · 2013: 2
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Infection (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida tropicalis, septic arthritis, acute myeloid leukemia, fluconazole, antifungal therapy, synovial fluid, fungal arthritis, knee joint infection, chemotherapy-induced immunosuppression
- MeSH terms
- Aged, Antifungal Agents, Arthritis, Infectious, Candidiasis, Child, Female, Humans, Infant, Newborn, Knee, Male, Middle Aged, Shoulder, Leukemia, Myeloid, Acute, Fluconazole
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