Candida prosthetic arthritis: report of a case treated with fluconazole and review of the literature
Abstract
Prosthetic arthritis due to Candida species is uncommon, with only 15 cases reported in the literature. We recently cared for a human immunodeficiency virus-infected patient who developed Candida parapsilosis prosthetic arthritis unresponsive to resection arthroplasty, intravenous amphotericin B, and suppressive ketoconazole therapy. Treatment with fluconazole led to mycologic cure and symptom improvement, although he subsequently underwent above-the-knee amputation due to continued joint instability. Fluconazole may be useful follow-up therapy after a course of amphotericin B combined with resection arthroplasty or when removal of the prosthesis cannot be accomplished.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Candida arthritis that involves a prosthetic joint generally requires resection arthroplasty.
“Candida arthritis that involves a prosthetic joint generally requires resection arthroplasty [198].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [198]
Cites
Azole antifungal agents: Emphasis on new triazoles
Saag, M. S., & Dismukes, W. E. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.1.1 · Cited by 474 · see citing works
Pharmacokinetics and Tissue Penetration of Fluconazole in Humans
Brammer, K. W., Farrow, P. R., & Faulkner, J. K. (1990) · Clinical Infectious Diseases · doi:10.1093/clinids/12.supplement_3.s318 · Cited by 430 · see citing works
Azole Antifungal Drugs: Old and New
Dismukes, W. E. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-3-177 · Cited by 106 · see citing works
Periprosthetic Candidal Infections Following Arthroplasty
Darouiche, R. O., Hamill, R. J., Musher, D. M., et al. (1989) · Clinical Infectious Diseases · doi:10.1093/clinids/11.1.89 · Cited by 90 · see citing works
Fluconazole in the treatment of candidal prosthetic valve endocarditis.
Isalska, B. J., & Stanbridge, T. N. (1988) · BMJ · doi:10.1136/bmj.297.6642.178 · Cited by 65 · see citing works
Fungal infection of prosthetic joints: a report of two cases.
Js, G., Dg, S., Reahl, G. E., et al. (1983) · PubMed · Cited by 65 · see citing works
Fungal Prostbetic Artbritis: Presentation of Two Cases and Review of the Literature
Lambertus, M. W., Tbordarson, D., & Goetz, M. B. (1988) · Clinical Infectious Diseases · doi:10.1093/clinids/10.5.1038 · Cited by 62 · see citing works
Infection with Candida albicans of a Total Knee Arthroplasty
Levine, M. I., Rehm, S. J., & Wilde, A. H. (1988) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198801000-00031 · Cited by 59 · see citing works
Galgiani, J. N. (1990) · Clinical Infectious Diseases · doi:10.1093/clinids/12.supplement_3.s272 · Cited by 58 · see citing works
Rr, M., Schimmer, B. M., & Steinberg, M. E. (1980) · PubMed · Cited by 56 · see citing works
Candida infection after implant arthroplasty. A case report.
Lim, E. V. A., & Stern, P. J. (1986) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198668010-00020 · Cited by 55 · see citing works
Candida parapsilosis infection of a total hip-joint replacement
Younkin, S. W., Evarts, C. M., & Steigbigel, R. T. (1984) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198466010-00023 · Cited by 50 · see citing works
Candida albicans infection of a prosthetic knee replacement: a report and review of the literature.
Koch, A. E. (1988) · PubMed · Cited by 48 · see citing works
Candida infection of a prosthetic shoulder joint
Lichtman, E. A. (1983) · Skeletal Radiology · doi:10.1007/bf00357775 · Cited by 40 · see citing works
Candida albicans infection of a prosthetic knee replacement.
Mk, I., & Ma, K. (1988) · PubMed · Cited by 30 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191 · see citing works
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440 · see citing works
Cornely, O. A., Bassetti, M., Calandra, T., Garbino, J., Kullberg, B. J., Lortholary, O., Meersseman, W., Akova, M., Arendrup, M. C., Arikan-Akdagli, S., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12039 · Cited by 1,217 · see citing works
Practice Guidelines for the Treatment of Candidiasis
Rex, J. H., Walsh, T. J., Sobel, J. D., Filler, S. G., Pappas, P. G., Dismukes, W. E., & Edwards, J. E. (2000) · Clinical Infectious Diseases · doi:10.1086/313749 · Cited by 927 · see citing works
Candida parapsilosis: from genes to the bedside
Tóth, R., Nosek, J., Mora-Montes, H. M., Gabaldon, T., Bliss, J. M., Nosanchuk, J. D., Turner, S. A., Butler, G., Vágvölgyi, C., & Gácser, A. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00111-18 · Cited by 327 · see citing works
Invasive candidiasis in immunocompromised hospitalized patients.
Sims, C. R., Ostrosky-Zeichner, L., & Rex, J. H. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.05.015 · Cited by 124 · see citing works
Weers-Pothoff, G., Havermans, J. F., Kamphuis, J., Sinnige, H. A. M., & Meis, J. F. G. M. (1997) · Infection · doi:10.1007/bf02113588 · Cited by 27 · see citing works
- Authors
- Tunkel, A. R., Thomas, C. Y., & Wispelwey, B.
- Affiliations
- University of Virginia Health System (US)
- University of Virginia (US)
- Corresponding author
- Tunkel, Allan R.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1993-01
- Volume
- 94
- Issue
- 1
- Pages
- 100-103
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2018243232
- Cited by
- 90
- References
- 15
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida parapsilosis, fluconazole, HIV infection, amphotericin B, resection arthroplasty, transfemoral amputation, prosthesis removal
- MeSH terms
- Adult, Arthritis, Infectious, Candidiasis, Humans, Knee Prosthesis, Male, HIV Infections, Fluconazole, Prosthesis-Related Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
