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Cited by 8Schizophrenia research and treatmentHeart Rate Variability and Autonomic ControlStress Responses and Cortisol

Electrodermal and vascular orienting response in schizophrenic patients: Relationship to symptoms and medication

Schlenker, Regine, Cohen, Rudolf, Hubmann, Werner, Mohr, Fritz, Wahlheim, Christine, Watzl, Hans, Werther, Petra·1995·European Archives of Psychiatry and Clinical Neuroscience
DOI 10.1007/bf02193088
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Abstract

Peripheral indicators of autonomic nervous system activity, including electrodermal activity and finger-pulse volume, were investigated in 100 schizophrenic inpatients. Healthy siblings of the patients and healthy subjects matched for age and gender served as control groups. Acoustic stimuli (70 dB) were presented and orienting response (OR) parameters were determined independently for the two response systems. The relationship of both OR measures to negative symptoms and medication was studied. The two OR measures were found to be not interrelated, i.e. most of the subjects were discordant with regard to presence or absence of their OR in the two different response systems. The electrodermal, but not the vascular OR, differed between patients and control groups. Among patients receiving medication with anticholinergic effects there were significantly more electrodermal nonresponders than among patients without such medication. There was no indication that electrodermal nonresponders show more negative symptoms or generally more severe psychopathology than electrodermal responders.

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Crossref · 10.1007/bf02193088

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  • Approximately 40-60% of the schizophrenia population has been classified as electrodermal activity non-responders, substantially greater than the proportion of healthy individuals who are non-responders.

    “Approximately 40–60% of the SCZ population has been classified as EDA non-responders gave their significantly suppressed skin conductance in response to noxious stimuli40,41; this is substantially greater than the proportion of healthy individuals that are EDA non-responders39.”

    From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [40]

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Authors
Schlenker, R., Cohen, R., Hubmann, W., Mohr, F., Wahlheim, C., Watzl, H., & Werther, P.
Affiliations
University of Konstanz (DE)
Venue
European Archives of Psychiatry and Clinical Neuroscience
Publisher
Springer Science and Business Media LLC
Published
1995-05
Volume
245
Issue
3
Pages
152-158
ISSN
  • 0003-9373 (ISSN-L)
  • 0940-1334
  • 1433-8491
DOI
10.1007/bf02193088
OpenAlex
W2053243230
Cited by
8
References
27
Citations by year
2021: 1 · 2018: 1 · 2015: 1
FWCI
0.31
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
schizophrenia, orienting response, electrodermal activity, autonomic nervous system, negative symptoms, anticholinergic agents, acoustic stimuli
MeSH terms
Adult, Antidepressive Agents, Tricyclic, Antiparkinson Agents, Autonomic Nervous System, Female, Galvanic Skin Response, Humans, Male, Psychiatric Status Rating Scales, Schizophrenia, Antipsychotic Agents

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