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Cited by 68Sleep and related disordersTreatment of Major DepressionSleep and Wakefulness Research

Changes in sleep polygraphic variables and clinical state in depressed patients during treatment with citalopram

van Bemmel, Alex L., van den Hoofdakker, Rutger H., Beersma, Domien G. M., Bouhuys, Antoinette L.·1993·Psychopharmacology
DOI 10.1007/bf02245702
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Abstract

Drug-induced improvement of depression may be mediated by changes in sleep physiology. The aim of this study was to relate changes in sleep polygraphic variables to clinical state during treatment with citalopram, a highly specific serotonin uptake inhibitor. Sixteen patients took part. The study was single-blind and uncontrolled. A 1-week wash-out period was followed by 1 week of placebo administration, a medication period of 5 weeks, and a 1-week placebo period. For the entire group a significant decrease of rapid eye movement sleep (REMS) and a significant lengthening of REMS latency were observed initially as well as at the end of treatment. No changes in sleep continuity were found, but non-REMS stage 2 (percentage) was significantly increased. On the basis of clinical change, as expressed by the scores of the Hamilton Rating Scale for Depression, at the end of the citalopram treatment the patient group was split in two halves: eight less and eight more improved patients. The groups did not differ with respect to any sleep polygraphic variable.

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Crossref · 10.1007/bf02245702

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  • In the citalopram study, no changes in sleep continuity measures were noted and Stage II sleep increased.

    “No changes in sleep continuity measures were noted and Stage II sleep increased [van Bemmel et al., 1993].”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as van Bemmel et al., 1993

  • Citalopram's REM suppressant effects appear similar to those of other antidepressants of this class.

    “The REM suppressant effects of citalopram appear to be similar to those of the other antidepressants of this class.”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as van Bemmel et al., 1993

  • In 16 depressed patients treated with citalopram, there was a significant decrease in REM sleep and increased REM latency at both 1 and 5 weeks of therapy.

    “A study of 16 depressed patients treated with citalopram found a significant decrease in REM sleep and increased REM latency at both 1 and 5 weeks of therapy.”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as van Bemmel et al., 1993

Cites

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Research works printed but not linked: 24

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Authors
van Bemmel, A. L., van den Hoofdakker, R. H., Beersma, D. G. M., & Bouhuys, A. L.
Affiliations
  • Maastricht University (NL)
  • University of Groningen (NL)
ORCID
Beersma, Domien G. M.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1993-12
Volume
113
Issue
2
Pages
225-230
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf02245702
OpenAlex
W2027320845
Cited by
68
References
2
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2014: 2 · 2012: 4
FWCI
4.14
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders
Institut National de la Santé et de la Recherche Médicale
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
citalopram, depression, sleep polygraphy, REM sleep, REM latency, sleep continuity, serotonin reuptake inhibitors, antidepressant response, Hamilton Depression Rating Scale
MeSH terms
Adult, Affect, Depression, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sleep, Sleep Stages, Sleep, REM, Citalopram, Single-Blind Method, Polysomnography

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