CoChat
Sign Up
Cited by 66Treatment of Major DepressionSuicide and Self-Harm StudiesElectroconvulsive Therapy Studies

Antisuicidal response following ketamine infusion is associated with decreased nighttime wakefulness in major depressive disorder and bipolar disorder

Open access
Vande Voort, Jennifer L., Ballard, Elizabeth D., Luckenbaugh, David A., Bernert, Rebecca A., Richards, Erica M., Niciu, Mark J., Park, Lawrence T., Machado-Vieira, Rodrigo +2 more·2017·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.15m10440PMC PMC5641476
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Insomnia and disrupted sleep are associated with increased risk of suicide. The N-methyl-d-aspartate antagonist ketamine has been associated with reduced suicidal thoughts, but the mechanism of action is unknown. This study sought to evaluate differences in nocturnal wakefulness in depressed individuals who did and did not have an antisuicidal response to ketamine. METHODS: Thirty-four participants with baseline suicidal ideation diagnosed with either DSM-IV major depressive disorder (n = 23) or bipolar depression (n = 11) between 2006 and 2013 completed nighttime electroencephalography (EEG) the night before and the night after a single ketamine infusion (0.5 mg/kg over 40 minutes). Suicidal ideation was assessed at baseline and the morning after ketamine infusion via several measures, including the Hamilton Depression Rating Scale suicide item, the suicide item of the Montgomery-Asberg Depression Rating Scale, and the first 5 items of the Scale for Suicide Ideation. A generalized linear mixed model evaluated differences in nocturnal wakefulness, as verified by EEG, between those who had an antisuicidal response to ketamine and those who did not, controlling for baseline nocturnal wakefulness. Results were also compared to the sleep of healthy controls (n = 22). RESULTS: After analyses adjusted for baseline sleep, participants with an antisuicidal response to ketamine showed significantly reduced nocturnal wakefulness the night after ketamine infusion compared to those without an antisuicidal response (F₁,₂₂ = 5.04, P = .04). Level of nocturnal wakefulness after antisuicidal response to ketamine did not differ significantly from nocturnal wakefulness in the control sample but did differ at a trend level (F₁,₄₀ = 3.15, P = .08). CONCLUSIONS: Reductions in wakefulness following ketamine may point to a biological mechanism underlying the effect of ketamine on suicidal ideation. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00088699.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4088/jcp.15m10440

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • There is some experimental evidence that ketamine may reduce suicidality through normalizing sleep.

    “Even more implicative of a possible causal role for sleep disturbance in suicide risk, again in terms of suicidal ideation, there is some experimental evidence that ketamine may exert an anti-suicidal effect through its effect on normalizing sleep (Vande Voort et al., 2017).”

    From Sleep and suicide: A systematic review and meta-analysis of longitudinal studies (2020) · cites this paper as Vande Voort et al., 2017

  • Overall sleep improvement, especially reduction in objective electroencephalogram early-night awakening, may be a mechanism by which ketamine exerts its anti-suicidal effects.

    “Overall sleep improvement, especially reduction in objective electroencephalogram early-night awakening, may be a mechanism by which ketamine exerts its anti-suicidal effects.139”

    From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [139]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [36]Brown GK A Review of Suicide Assessment Measures for Intervention Research With Adults and Older Adults National Institute of Mental Health 2000

Cited by

Sorted by citations

Related

Authors
Vande Voort, J. L., Ballard, E. D., Luckenbaugh, D. A., Bernert, R. A., Richards, E. M., Niciu, M. J., Park, L. T., Machado-Vieira, R., Duncan, W. C., & Zarate, C. A.
Affiliations
  • National Institutes of Health (US)
  • Stanford University (US)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2017-10-25
Volume
78
Issue
8
Pages
1068-1074
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.15m10440
PMC
PMC5641476
OpenAlex
W2560112018
Semantic Scholar
2ef6b35ba5beade139c9b710d71f697b18e583da
Cited by
65
References
45
Citations by year
2026: 4 · 2025: 3 · 2024: 3 · 2023: 11 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 5
FWCI
4.86
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Mayo Clinic
  • National Institutes of Health
  • National Institute of Mental Health (K23MH093490, ZIAMH002857)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
ketamine, suicidal ideation, nocturnal wakefulness, major depressive disorder, bipolar depression, insomnia, sleep disruption, NMDA receptor antagonists, EEG, suicide risk
MeSH terms
Suicide Prevention, Adult, Bipolar Disorder, Depressive Disorder, Major, Major Depressive Disorder, Drug Resistance, Electroencephalography, Female, Humans, Ketamine, Male, Middle Aged, Psychiatric Status Rating Scales, Suicide, Wakefulness, Treatment Outcome, Drug Monitoring, Excitatory Amino Acid Antagonists, Diagnostic and Statistical Manual of Mental Disorders, Suicidal Ideation, Administration, Intravenous

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review