5HT drugs in animal models of anxiety

Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822

The Neuropsychology of Anxiety: An enquiry into the function of the septo-hippocampal system

Gray, J. A., & McNaughton, N. (2003) · doi:10.1093/acprof:oso/9780198522713.001.0001 · Cited by 1,928

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., & Saxena, P. R. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90207-8 · Cited by 1,258

5-HT and mechanisms of defence

Deakin, J. F. W., & Graeff, F. G. (1991) · Journal of Psychopharmacology · doi:10.1177/026988119100500414 · Cited by 1,010

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

Handley, S. L., & Mithani, S. (1984) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/bf00504983 · Cited by 969

Ethologically-based animal models of anxiety disorders

Lister, R. G. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90021-s · Cited by 845

Emotional memory systems in the brain

LeDoux, J. E. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90091-4 · Cited by 816

CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?

FILE, S. E., & HYDE, J. R. G. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb07001.x · Cited by 803

Serotonin function in anxiety: II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects

Charney, D. S., Woods, S. W., Goodman, W. K., & Heninger, G. R. (1987) · Psychopharmacology · doi:10.1007/bf00215473 · Cited by 462

The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat

Tenen, S. S. (1967) · Psychopharmacologia · doi:10.1007/bf00401382 · Cited by 430

The concept of selectivity in 5-HT receptor research

Van Wijngaarden, I., Tulp, M. T. M., & Soudijn, W. (1990) · European Journal of Pharmacology: Molecular Pharmacology · doi:10.1016/0922-4106(90)90190-9 · Cited by 421

The neuropsychology of anxiety

Lader, M. (1983) · Personality and Individual Differences · doi:10.1016/0191-8869(83)90137-x · Cited by 416

5-HT1A receptor-related anxiolytics

Traber, J., & Glaser, T. (1987) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(87)90231-8 · Cited by 404

Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors

Peroutka, S. J. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90194-5 · Cited by 369

5-HT and anxiety

IVERSEN, S. (1984) · Neuropharmacology · doi:10.1016/0028-3908(84)90099-6 · Cited by 322

Role of the amygdala and periaqueductal gray in anxiety and panic.

Graeff, F. G., Silveira, M. C. L., Nogueira, R. L., Audi, E. A., & Oliveira, R. M. W. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90097-a · Cited by 301

Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists

Kennett, G. A., Whitton, P., Shah, K., & Curzon, G. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90252-5 · Cited by 281

Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not on discrimination

Hodges, H., Green, S., & Glenn, B. (1987) · Psychopharmacology · doi:10.1007/bf00176484 · Cited by 242

Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug

VanderMaelen, C. P., Matheson, G. K., Wilderman, R. C., & Patterson, L. A. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90343-2 · Cited by 233

Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists.

Meller, E., Goldstein, M., & Bohmaker, K. (1990) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09962-6 · Cited by 231

Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression

Kennett, G. A., Dourish, C. T., & Curzon, G. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90357-8 · Cited by 228

The Influence of Ritanserin, a Serotonin Antagonist, in Anxiety Disorders: A Double-blind Placebo-controlled Study versus Lorazepam

Ceulemans, D., Hoppenbrouwers, M.-L., Gelders, Y., & Reyntjens, A. (1985) · Pharmacopsychiatry · doi:10.1055/s-2007-1017385 · Cited by 226

Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

Engel, J. A., Hjorth, S., Svensson, K., Carlsson, A., & Liljequist, S. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90634-4 · Cited by 221

An assessment of the elevated X-maze for studying anxiety and anxiety-modulating drugs

Handley, S. L., & McBlane, J. W. (1993) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/1056-8719(93)90063-k · Cited by 214

5-HT Receptors: Subtypes and Second Messengers

Hoyer, D., & Schoeffter, P. (1991) · Journal of Receptor Research · doi:10.3109/10799899109066399 · Cited by 201

Serotonergic mechanisms in the behavioral effects of buspirone and gepirone

Eison, A. S., Eison, M. S., Stanley, M., & Riblet, L. A. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90577-0 · Cited by 197

Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin

Den Boer, J. A., & Westenberg, H. G. M. (1990) · Psychopharmacology · doi:10.1007/bf02245749 · Cited by 197

Inhibition of Serotonin Synthesis by Para-Chlorophenylalanine in Patients with the Carcinoid Syndrome

Engelman, K., Lovenberg, W., & Sjoerdsma, A. (1967) · New England Journal of Medicine · doi:10.1056/nejm196711232772101 · Cited by 197

An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone

Moser, P. C. (1989) · Psychopharmacology · doi:10.1007/bf00634451 · Cited by 189

Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the rat

Higgins, G. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90058-5 · Cited by 185

TRYPTAMINERGIC MECHANISMS IN PUNISHED AND NONPUNISHED BEHAVIOR

GRAEFF, F. G., & SCHOENFELD, R. I. (1970) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28566-4 · Cited by 180

Benzodiazepines reduce the tolerance to reward delay in rats

Thiébot, M.-H., Le Bihan, C., Soubrié, P., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00431700 · Cited by 161

Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors

Critchley, M. A. E., & Handley, S. L. (1987) · Psychopharmacology · doi:10.1007/bf00207243 · Cited by 158

Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat

Pellow, S., Johnston, A. L., & File, S. E. (1987) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1987.tb03129.x · Cited by 157

Multiple serotonin mechanisms in animal models of anxiety

Handley, S. L., McBlane, J. W., Critchley, M. A. E., & Njung'e, K. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90104-x · Cited by 150

Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons

Bockaert, J., Dumuis, A., Bouhelal, R., Sebben, M., & Cory, R. N. (1987) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169129 · Cited by 142

The effects of p-chlorophenylalanine on experimentally induced conflict in the rat

Robichaud, R. C., & Sledge, K. (1969) · Life Sciences · doi:10.1016/0024-3205(69)90427-5 · Cited by 136

The effects of benzodiazepines and serotonergic manipulations on punished responding

Tye, N. C. (1979) · Neuropharmacology · doi:10.1016/0028-3908(79)90036-4 · Cited by 136

Pharmacological Characterisation of a Modified Social Interaction Model of Anxiety in the Rat

Guy, A. P., & Gardner, C. R. (2008) · Neuropsychobiology · doi:10.1159/000118187 · Cited by 133

Buspirone: Action on serotonin receptors in calf hippocampus

Gläser, T., & Traber, J. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90404-1 · Cited by 127

Review of the side-effect profile of buspirone

Newton, R. E., Marunycz, J. D., Alderdice, M. T., & Napoliello, M. J. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90327-x · Cited by 126

Recent developments in 5HT-related pharmacology of animal models of anxiety

Gardner, C. R. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90215-7 · Cited by 126

Monoaminergic mechanisms in aversive brain stimulation

Kiser, R. S., & Lebovitz, R. M. (1975) · Physiology & Behavior · doi:10.1016/0031-9384(75)90278-4 · Cited by 124

Intra-hippocampal buspirone in animal models of anxiety

Kostowski, W., Płaźnik, A., & Stefański, R. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90803-0 · Cited by 123

Hippocampal 5-HT receptors and consolidation of stressful memories

Guimarães, F. S., Bel, E. A. D., Padovan, C. M., Netto, S. M., & Titze‐de‐Almeida, R. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90098-b · Cited by 115

Characterization of MDL 73005EF as a 5‐HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam

Moser, P. C., Tricklebank, M. D., Middlemiss, D. N., Mir, A. K., Hibert, M., & Fozard, J. R. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14706.x · Cited by 115

Effects of ritanserin on aversive classical conditioning in humans

Hensman, R., Guimarães, F. S., Wang, M., & Deakin, J. F. W. (1991) · Psychopharmacology · doi:10.1007/bf02244182 · Cited by 112

Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

File, S. E., & Johnston, A. L. (1989) · Psychopharmacology · doi:10.1007/bf00442817 · Cited by 111

Neuroanatomical sites of action of 5‐HT3 receptor agonist and antagonists for alteration of aversive behaviour in the mouse

Costall, B., Kelly, M. E., Naylor, R. J., Onaivi, E. S., & Tyers, M. B. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb11821.x · Cited by 110

Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test

Söderpalm, B., Hjorth, S., & Engel, J. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90242-6 · Cited by 107

The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects

Charney, D. S., Heninger, G. R., Reinhard, J. F., Sternberg, D. E., & Hafstead, K. M. (1982) · Psychopharmacology · doi:10.1007/bf00464569 · Cited by 102

Attenuation of chemically induced defence response by 5-HT1 receptor agonists administered into the periaqueductal gray

Beckett, S. R. G., Lawrence, A. J., Marsden, C. A., & Marshall, P. W. (1992) · Psychopharmacology · doi:10.1007/bf02245294 · Cited by 101

Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus

Whitton, P. S., & Curzon, G. (1990) · Psychopharmacology · doi:10.1007/bf02245806 · Cited by 95

Central Serotonin Receptors and Psychotropic Drugs

Tricklebank, M. D. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90126-7 · Cited by 88

Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands

Mansbach, R. S., & Geyer, M. A. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90283-x · Cited by 86

Effect of metergoline on human anxiety

Graeff, F. G., Zuardi, A. W., Giglio, J. S., Filho, E. C. L., & Karniol, I. G. (1985) · Psychopharmacology · doi:10.1007/bf00432224 · Cited by 86

The Involvement of Serotonin in Psychiatric Disorders and Behaviour

López-Ibor, J. J. (1988) · The British Journal of Psychiatry · doi:10.1192/s0007125000297262 · Cited by 84

Evidence that the amygdala is involved in the disinhibitory effects of 5-HT3 receptor antagonists

Higgins, G. A., Jones, B. J., Oakley, N. R., & Tyers, M. B. (1991) · Psychopharmacology · doi:10.1007/bf02245664 · Cited by 83

Serotonergic modulation of the rat pup ultrasonic isolation call: studies with 5HT1 and 5HT2 subtype-selective agonists and antagonists

Winslow, J., & Insel, T. R. (1991) · Psychopharmacology · doi:10.1007/bf02244372 · Cited by 82

Clinical pharmacology of anxiolytics and antidepressants: A psychopharmacological perspective

Nutt, D., & Glue, P. (1989) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(89)90006-5 · Cited by 80

Are serotonergic neurons involved in the control of anxiety and in the anxiolytic activity of benzodiazepines?

Thiébot, M.-H. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90214-5 · Cited by 74

Animal models of psychiatric disorders

Gordon, J. A., & Dzirasa, K. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.004 · Cited by 73

Effects of blockade of 5-HT2 receptors and activation of 5-HT1A receptors on the exploratory activity of rats in the elevated plus-maze

Motta, V., Maisonnette, S. S., Morato, S., Castrechini, P., & Brandão, M. L. (1992) · Psychopharmacology · doi:10.1007/bf02244978 · Cited by 70

Serotonin, sleep and mental disorder

Idzikowski, C., & Cowen, P. J. (1991) · Medical Entomology and Zoology · Cited by 66

Comparison of acute and chronic treatment of various serotonergic agents with those of diazepam and idazoxan in the rat elevated X-maze

Wright, I. K., Heaton, M., Upton, N., & Marsden, C. A. (1992) · Psychopharmacology · doi:10.1007/bf02245168 · Cited by 66

Electrophysiological Investigation of the Adaptive Response of the 5-HT System to the Administration of 5-HT1A Receptor Agonists

Blier, P. U., & de Montigny, C. (1990) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199000157-00006 · Cited by 64

Modulation of baseline behavior in rats by putative serotonergic agents in three ethoexperimental paradigms

Kshama, D., Hrishikeshavan, H. J., Shanbhogue, R., & Munonyedi, U. S. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90617-f · Cited by 61

The involvement of nigral serotonin innervation in the control of punishment-induced behavioral inhibition in rats

Thiébot, M.-H., Hamon, M., & Soubrié, P. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90043-6 · Cited by 57

Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions

Critchley, M. A. E., Njung'e, K., & Handley, S. L. (1992) · Psychopharmacology · doi:10.1007/bf02244819 · Cited by 57

Electrophysiological Investigation of the Adaptive Response of the 5-HT System to the Administration of 5-HT1A Receptor Agonists

Blier, P. U., & de Montigny, C. (1990) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199001001-00006 · Cited by 56

Opposite control mediated by central 5-HT1A and non-5-HT1A (5-HT1B or 5-HT1C) receptors on periaqueductal gray aversion

Jenck, F., Broekkamp, C. L. E., & Delft, A. M. L. V. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90847-9 · Cited by 55

5-HT1C receptors in the serotonergic control of periaqueductal gray induced aversion in rats

Jenck, F., Broekkamp, C. L. E., & Delft, A. M. L. V. (1990) · Psychopharmacology · doi:10.1007/bf02244609 · Cited by 53

The relative efficacy of buspirone, imipramine and placebo in panic disorder: A preliminary report

Sheenan, D. V., Raj, A. B., Sheehan, K. H., & Soto, S. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90214-6 · Cited by 51

Benzodiazepines, putative anxiolytics and animal models of anxiety

Green, S. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90070-b · Cited by 47

Theory in psychopharmacology, vol. 1

Mason, S. T. (1983) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(83)90276-6 · Cited by 44

Microinjection of propranolol into the dorsal periaqueductal gray causes an anxiolytic effect in the elevated plus-maze antagonized by ritanserin

Audi, E. A., de Oliveira, R. M. W., & Graeff, F. G. (1991) · Psychopharmacology · doi:10.1007/bf02244379 · Cited by 41

Effects of 8-OH-DPAT and buspirone in a passive avoidance test and in the elevated plus-maze test in rats

Klint, T. (1991) · Behavioural Pharmacology · doi:10.1097/00008877-199112000-00005 · Cited by 33

Decreased reactivity to anxiolytics caused by early protein malnutrition in rats

Almeida, S. S., Oliveira, L. M. D., & Graeff, F. G. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90113-v · Cited by 33

Variability in behavioral responses to benzodiazepines in the rat

File, S. E. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90383-0 · Cited by 27

Chronic Hemodynamic Effects of Tiapamil and Felodipine in Essential Hypertension at Rest and During Exercise

Lund‐Johansen, P., & Omvik, P. (1990) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199015004-00014 · Cited by 22

5-HT-the disengaging transmitter?

Handley, S. L., & McBlane, J. W. (1991) · Journal of Psychopharmacology · doi:10.1177/026988119100500417 · Cited by 21

Ipsapirone reduces increases in anxiety during a simulated public speaking test

Guimarães, F. S., Cosme, R. A., Zuardi, A. W., & Graeff, F. G. (1990) · Journal of Psychopharmacology · Cited by 3

A review of central 5-HT receptors and their function

Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,161

The spectrum of behaviors influenced by serotonin

Lucki, I. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00139-5 · Cited by 1,158

Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety

Shepherd, J. K., Grewal, S. S., Fletcher, A., Bill, D. J., & Dourish, C. T. (1994) · Psychopharmacology · doi:10.1007/bf02244871 · Cited by 739

Chronic Unpredictable Stress Induces a Cognitive Deficit and Anxiety-Like Behavior in Rats that is Prevented by Chronic Antidepressant Drug Treatment

Bondi, C. O., Rodriguez, G., Gould, G. G., Frazer, A., & Morilak, D. A. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301410 · Cited by 398

The elevated T-maze as an experimental model of anxiety

Graeff, F. G., Ferreira Netto, C., & Zangrossi Jr, H. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00024-4 · Cited by 391