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Cited by 344

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone‐exposed rats

Chow, C. K., Tappel, A. L.·1972·Lipids
DOI 10.1007/bf02533017
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Abstract

The effects of whole animal exposure to ozone and of dietary α‐tocopherol on the occurrence in rat lung of lipid peroxidation and alteration of the activity of enzymes important in detoxification of lipid peroxides were studied. Exposure to 0.7 and 0.8 ppm ozone continuously for 5 and 7 days, respectively, significantly elevated the concentration of TBA reactants, primarily malonaldehyde, produced by lipid peroxidation, as well as the activities of glutathione (GSH) peroxidase, GSH reductase and glucose‐6‐phosphate (G‐6‐P) dehydrogenase. As a logarithmic function of dietary α‐tocopherol (0, 10.5, 45, 150 and 1500 mg/kg), the increase in formation of malonaldehyde and the increase in activities of GSH peroxidase and G‐6‐P dehydrogenase were partially inhibited. The activity of GSH reductase was not affected by dietary α‐tocopherol. The concentration of malonaldehyde and the activity of GSH peroxidase in lung were linearly correlated (p<0.001). This study confirmed the occurrence of lipid peroxidation in the lung during ozone exposure and revealed an enzymatic mechanism against damage. An apparent compensation mechanism is that with increased lipid peroxides there is increased activity of GSH peroxidase, which in turn increases lipid peroxide catabolism. The increased activities of GSH reductase and G‐6‐P dehydrogenase also function in the protective chain by providing increased levels of GSH and NADPH, respectively.

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Metadata

Authors
Chow, C. K., & Tappel, A. L.
Venue
Lipids
Publisher
Wiley
Published
1972-08
Volume
7
Issue
8
Pages
518-524
ISSN
  • 0024-4201 (ISSN-L)
  • 1558-9307
DOI
10.1007/bf02533017
OpenAlex
W2082970077
Cited by
344
References
17
FWCI
16.43
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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