Making sense of the multiple MAP-2 transcripts and their role in the neuron
Abstract
Microtubule-associated protein-2 (MAP-2) is a family of heat-stable, phosphoproteins expressed predominantly in the cell body and dendrites of neurons. Three major MAP-2 isoforms, (MAP-2a, MAP-2b, MAP-2c) are differentially expressed during the development of the nervous system and have an important role in microtubule dynamics. Several MAP-2 cDNA clones that correspond to the major MAP-2 transcripts and additional, novel MAP-2 transcripts expressed in the CNS and PNS have been characterized. The transcripts result from the alternative splicing of a single MAP-2 gene consisting of 20 exons. Studies are now being directed toward understanding the role of the multiple MAP-2 forms that contain novel exons in the nervous system. The expression, localization, and possible functions of the newly identified spliced forms are the focus of this review.
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MAP2 features splice variants with three or four microtubule binding repeats, with 3R isoforms predominant.
“Like tau, MAP2 features different splice variants that may have either three or four microtubule binding repeats (29), with 3R isoforms being predominant.”
From MAP2 caps tau fibrils and inhibits aggregation (2023) · cites this paper as [29]
Cites
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Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372 · see citing works
Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus
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Self-citationHuang, Y., Wu, H., Tai, N., & Wang, T. (2012) · Small · doi:10.1002/smll.201200715 · Cited by 149 · see citing works
MAP2 caps tau fibrils and inhibits aggregation
Holden, M. R., Krzesinski, B. J., Weismiller, H. A., Shady, J. R., & Margittai, M. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104891 · Cited by 13 · see citing works
- Authors
- Shafit-Zagardo, B., & Kalcheva, N.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Molecular Neurobiology
- Published
- 1998-04
- Volume
- 16
- Issue
- 2
- Pages
- 149-162
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W1993391698
- Cited by
- 89
- References
- 5
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- MAP2, alternative splicing, novel exons, neuronal cytoskeleton, microtubule dynamics, dendrites, gene expression
- MeSH terms
- Animals, Humans, Microtubule-Associated Proteins, Neurons, RNA, Messenger
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