Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.

Microtubule Assembly in the Absence of Added Nucleotides

Shelanski, M. L., Gaskin, F., & Cantor, C. R. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.3.765 · Cited by 2,065 · see citing works

The distribution of tau in the mammalian central nervous system.

Binder, L. I., Frankfurter, A., & Rebhun, L. I. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.4.1371 · Cited by 1,588 · see citing works

Intracellular transport in neurons.

Grafstein, B., & Forman, D. S. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1167 · Cited by 1,007 · see citing works

Altered microtubule organization in small-calibre axons of mice lacking tau protein

Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, S., Ohshima, T., Sato-Yoshitake, R., Takei, Y., Noda, T., & Hirokawa, N. (1994) · Nature · doi:10.1038/369488a0 · Cited by 806 · see citing works

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

Chen, J., Kanai, Y., Cowan, N. J., & Hirokawa, N. (1992) · Nature · doi:10.1038/360674a0 · Cited by 601 · see citing works

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

Matsuo, E. S., Shin, R., Billingsley, M., de Voorde, A. V., O'Connor, M., Trojanowski, J., & Lee, V. (1994) · Neuron · doi:10.1016/0896-6273(94)90264-x · Cited by 588 · see citing works

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer‐like state.

Drewes, G., Lichtenberg‐Kraag, B., Döring, F., Mandelkow, E. M., Biernat, J., Goris, J., Dorée, M., & Mandelkow, E. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05272.x · Cited by 565 · see citing works

Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites

Garner, C. C., Tucker, R. P., & Matus, A. I. (1988) · Nature · doi:10.1038/336674a0 · Cited by 558 · see citing works

A taxol-dependent procedure for the isolation of microtubules and microtubule-associated proteins (MAPs).

Vallee, R. B. (1982) · The Journal of cell biology · doi:10.1083/jcb.92.2.435 · Cited by 551 · see citing works

Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties.

Ransom, B., Neale, E., Henkart, M., Bullock, P., & Nelson, P. (1977) · Journal of Neurophysiology · doi:10.1152/jn.1977.40.5.1132 · Cited by 527 · see citing works

Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5

Baumann, K., Mandelkow, E., Biernat, J., Piwnica-Worms, H. M., & Mandelkow, E. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80849-p · Cited by 479 · see citing works

Microtubules and microtubule-associated proteins

Mandelkow, E., & Mandelkow, E.-M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80047-6 · Cited by 458 · see citing works

Light and electron microscopic studies of the distribution of microtubule-associated protein 2 in rat brain: a difference between dendritic and axonal cytoskeletons

Bernhardt, R., & Matus, A. (1984) · Journal of Comparative Neurology · doi:10.1002/cne.902260205 · Cited by 421 · see citing works

Phosphorylation determines two distinct species of tau in the central nervous system

Papasozomenos, S. C., & Binder, L. I. (1987) · Cell Motility · doi:10.1002/cm.970080303 · Cited by 420 · see citing works

Microtubule organization and dynamics dependent on microtubule-associated proteins

Hirokawa, N. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90119-8 · Cited by 412 · see citing works

Tau proteins: the molecular structure and mode of binding on microtubules.

Hirokawa, N., Shiomura, Y., & Okabe, S. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.4.1449 · Cited by 389 · see citing works

Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence

De Camilli, P., Miller, P. E., Navone, F., Theurkauf, W. E., & Vallee, R. B. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90194-5 · Cited by 381 · see citing works

MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum

Kosik, K., & Finch, E. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-10-03142.1987 · Cited by 368 · see citing works

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

Kanai, Y., Takemura, R., Oshima, T., Mori, H., Ihara, Y., Yanagisawa, M., Masaki, T., & Hirokawa, N. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.3.1173 · Cited by 360 · see citing works

Differential subcellular localization of tubulin and the microtubule- associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies

Cáceres, A., Binder, L., Payne, M., Bender, P. K., Rebhun, L. I., & Steward, O. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-02-00394.1984 · Cited by 352 · see citing works

Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends.

Gorbsky, G. J., Sammak, P. J., & Borisy, G. G. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.1.9 · Cited by 320 · see citing works

Molecular characterization of microtubule-associated proteins tau and map2

Goedert, M., Crowther, R. A., & Garner, C. C. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90105-4 · Cited by 315 · see citing works

Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau

Lewis, S. A., Ivanov, I. E., Lee, G., & Cowan, N. J. (1989) · Nature · doi:10.1038/342498a0 · Cited by 288 · see citing works

Overexpression of tau in a nonneuronal cell induces long cellular processes.

Knops, J., Kosik, K. S., Lee, G., Pardee, J. D., Cohen-Gould, L., & McConlogue, L. (1991) · The Journal of cell biology · doi:10.1083/jcb.114.4.725 · Cited by 286 · see citing works

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

Paudel, H. K., Lew, J., Ali, Z., & Wang, J. H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49492-1 · Cited by 285 · see citing works

Experimentally induced alteration in the polarity of developing neurons

Dotti, C. G., & Banker, G. A. (1987) · Nature · doi:10.1038/330254a0 · Cited by 278 · see citing works

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

Goedert, M., Cohen, E. S., Jakes, R., & Cohen, P. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81418-l · Cited by 272 · see citing works

A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubule

Kobayashi, S., Ishiguro, K., Omori, A., Takamatsu, M., Arioka, M., Imahori, K., & Uchida, T. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80723-8 · Cited by 234 · see citing works

Biochemical and immunological analyses of cytoskeletal domains of neurons.

Peng, I., Binder, L. I., & Black, M. M. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.1.252 · Cited by 230 · see citing works

Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells.

Brugg, B., & Matus, A. I. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.114.4.735 · Cited by 199 · see citing works

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

Ledesma, M. D., Correas, I., Ávila, J., & Díaz‐Nido, J. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81278-t · Cited by 189 · see citing works

Microtubule-associated protein 1B: Molecular structure, localization, and phosphorylation-dependent expression in developing neurons

Sato-Yoshitake, R., Shiomura, Y., Miyasaka, H., & Hirokawa, N. (1989) · Neuron · doi:10.1016/0896-6273(89)90036-6 · Cited by 188 · see citing works

MAP2 is a component of crossbridges between microtubules and neurofilaments in the neuronal cytoskeleton: quick-freeze, deep-etch immunoelectron microscopy and reconstitution studies

Hirokawa, N., Hisanaga, S., & Shiomura, Y. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02769.1988 · Cited by 186 · see citing works

Differential utilization of beta-tubulin isotypes in differentiating neurites.

Joshi, H. C., & Cleveland, D. W. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.2.663 · Cited by 180 · see citing works

[74] Microinjection of early SV40 DNA fragments and T antigen

Graessmann, A., Graessmann, M., & Mueller, C. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65076-9 · Cited by 178 · see citing works

Subcellular localization of tau mRNA in differentiating neuronal cell culture: Implications for neuronal polarity

Litman, P., Barg, J., Rindzoonski, L., & Ginzburg, I. (1993) · Neuron · doi:10.1016/0896-6273(93)90165-n · Cited by 178 · see citing works

Molecular Structure and Function of Microtubule-Associated Proteins

Wiche, G., Oberkanins, C., & Himmler, A. (1991) · International review of cytology · doi:10.1016/s0074-7696(08)61528-4 · Cited by 165 · see citing works

Cytoskeletal architecture and immunocytochemical localization of microtubule-associated proteins in regions of axons associated with rapid axonal transport: the beta,beta'-iminodipropionitrile-intoxicated axon as a model system.

Hirokawa, N., Bloom, G. S., & Vallee, R. B. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.1.227 · Cited by 165 · see citing works

Neuronal microtubule‐associated proteins in the embryonic avian spinal cord

Tucker, R. P., Binder, L. I., & Matus, A. I. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902710106 · Cited by 165 · see citing works

Proline-directed phosphorylation of human Tau protein.

Vulliet, R., Halloran, S. M., Braun, R., Smith, A. J., & Lee, G. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41710-3 · Cited by 164 · see citing works

Sorting mechanisms of Tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding

Kanai, Y., & Hirokawa, N. (1995) · Neuron · doi:10.1016/0896-6273(95)90298-8 · Cited by 144 · cited 6× · see citing works

Direct observation of steady-state microtubule dynamics.

Kristofferson, D., Mitchison, T. J., & Kirschner, M. W. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.3.1007 · Cited by 141 · see citing works

Both adult and juvenile tau microtubule-associated proteins are axon specific in the developing and adult rat cerebellum

Brion, J., Guilleminot, J., Couchie, D., Flament-Durand, J., & Nunfz, J. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90013-9 · Cited by 137 · see citing works

Microtubule dynamics in nerve cells: analysis using microinjection of biotinylated tubulin into PC12 cells.

Okabe, S., & Hirokawa, N. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.2.651 · Cited by 127 · see citing works

The sequential appearance of low- and high-molecular-weight forms of MAP2 in the developing cerebellum

Tucker, R., Binder, L., Viereck, C., Hemmings, B., & Matus, A. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-12-04503.1988 · Cited by 97 · see citing works

Axonal transport of a subclass of tau proteins: evidence for the regional differentiation of microtubules in neurons.

Tytell, M., Brady, S. T., & Lasek, R. J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.5.1570 · Cited by 90 · see citing works

Microtubule-associated protein 2 within axons of spinal motor neurons: associations with microtubules and neurofilaments in normal and beta,beta'-iminodipropionitrile-treated axons.

Papasozomenos, S. C., Binder, L. I., Bender, P. K., & Payne, M. R. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.100.1.74 · Cited by 90 · see citing works

Axonal transport of tubulin in tit pioneer neurons in situ

Sabry, J. H., O’Connor, T. P., & Kirschner, M. W. (1995) · Neuron · doi:10.1016/0896-6273(95)90271-6 · Cited by 86 · see citing works

Colocalization of microtubule-associated protein 1A and microtubule-associated protein 2 on neuronal microtubules in situ revealed with double-label immunoelectron microscopy.

Shiomura, Y., & Hirokawa, N. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.6.1575 · Cited by 84 · see citing works

The molecular structure of microtubule-associated protein 1A (MAP1A) in vivo and in vitro. An immunoelectron microscopy and quick-freeze, deep- etch study

Shiomura, Y., & Hirokawa, N. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-05-01461.1987 · Cited by 79 · see citing works

The microtubule cytoskeleton and the development of neuronal polarity

Mandell, J. W., & Banker, G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00164-v · Cited by 68 · see citing works

Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons.

Okabe, S., & Hirokawa, N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.4127 · Cited by 61 · see citing works

The low molecular weight form of microtubule-associated protein 2 is transported into both axons and dendrites

Meichsner, M., Doll, T., Reddy, D., Weisshaar, B., & Matus, A. I. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90581-y · Cited by 40 · see citing works

Synthesis, axonal transport, and turnover of the high molecular weight microtubule-associated protein MAP 1A in mouse retinal ganglion cells: tubulin and MAP 1A display distinct transport kinetics.

Nixon, R. A., Fischer, I., & Lewis, S. E. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.2.437 · Cited by 33 · see citing works

Microtubule MAPping

Cleveland, D. W. (1990) · Cell · doi:10.1016/0092-8674(90)90083-q · Cited by 32 · see citing works

Immunofluorescence distribution of α tubulin, β tubulin and microtubule-associated protein 2 during in vitro maturation of cerebellar granule cell neurones

Cumming, R., Burgoyne, R. D., & Lytton, N. A. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90169-6 · Cited by 30 · see citing works

The 72‐kDa Microtubule‐Associated Protein from Porcine Brain

Takeuchi, M., Hisanaga, S., Umeyama, T., & Hirokawa, N. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb11372.x · Cited by 11 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Tau in physiology and pathology

Wang, Y., & Mandelkow, E. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.1 · Cited by 2,251 · see citing works

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

Buée, L., Bussière, T., Buée‐Scherrer, V., Delacourte, A., & Hof, P. R. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00019-9 · Cited by 2,007 · see citing works

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

Ittner, L. M., & Götz, J. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2967 · Cited by 1,357 · see citing works

Kinesin Transports RNA

Kanai, Y., Dohmae, N., & Hirokawa, N. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.022 · Cited by 1,109 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

The MAP1 family of microtubule-associated proteins.

Dehmelt (2004) · Genome biology · doi:10.1186/gb-2004-6-1-204 · Cited by 972 · see citing works

Tau in Alzheimer's disease.

Mandelkow, E., & Mandelkow, E. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01368-3 · Cited by 951 · see citing works

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary DegenerationPreprint

Mandelkow, E., & Mandelkow, E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006247 · Cited by 839 · see citing works

Molecular motors and mechanisms of directional transport in neurons

Hirokawa, N., & Takemura, R. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1624 · Cited by 830 · see citing works

Microtubule-Based Transport Systems in Neurons: The Roles of Kinesins and Dyneins

Goldstein, L. S. B., & Yang, Z. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.39 · Cited by 552 · see citing works

Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function

Sánchez, C. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00046-5 · Cited by 512 · see citing works

The importance of tau phosphorylation for neurodegenerative diseases

Noble, W., Hanger, D. P., Miller, C. C. J., & Lovestone, S. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00083 · Cited by 475 · see citing works

MAPT mutations, tauopathy, and mechanisms of neurodegeneration

Strang, K. H., Golde, T. E., & Giasson, B. I. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0197-x · Cited by 424 · see citing works

Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction

Mietelska‐Porowska, A., Wasik, U., Goras, M., Filipek, A., & Niewiadomska, G. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15034671 · Cited by 407 · see citing works

Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head

Nakata, T., & Hirokawa, N. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302175 · Cited by 311 · see citing works

Missorting of Tau in Neurons Causes Degeneration of Synapses That Can Be Rescued by the Kinase MARK2/Par-1

Thies, E., & Mandelkow, E.-M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4674-06.2007 · Cited by 293 · see citing works

Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity

Biernat, J., Wu, Y.-Z., Timm, T., Zheng-Fischhöfer, Q., Mandelkow, E., Meijer, L., & Mandelkow, E.-M. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-03-0046 · Cited by 279 · see citing works

Dendritic Tau in Alzheimer’s Disease

Ittner, A., & Ittner, L. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.003 · Cited by 278 · see citing works

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

Zempel, H., & Mandelkow�, E. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.004 · Cited by 272 · see citing works

The Road Less Traveled: Emerging Principles of Kinesin Motor Utilization

Goldstein, L. S. B., & Philp, A. V. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.141 · Cited by 269 · see citing works

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

Li, X., Kumar, Y., Zempel, H., Mandelkow, E., Biernat, J., & Mandelkow, E. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.376 · Cited by 218 · see citing works

Regulation of microtubule-associated proteins

Cassimeris, L., & Spittle, C. S. (2001) · International review of cytology · doi:10.1016/s0074-7696(01)10006-9 · Cited by 220 · see citing works

Atypical, non-standard functions of the microtubule associated Tau protein

Sotiropoulos, I., Galas, M., Silva, J. M., Skoulakis, E. M. C., Wegmann, S., Maina, M. B., Blum, D. L., Sayas, C. L., Mandelkow, E., Mandelkow�, E., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0489-6 · Cited by 211 · see citing works

A Common Mechanism for Microtubule Destabilizers—M Type Kinesins Stabilize Curling of the Protofilament Using the Class-Specific Neck and Loops

Ogawa, T., Nitta, R., Okada, Y., & Hirokawa, N. (2004) · Cell · doi:10.1016/s0092-8674(04)00129-1 · Cited by 199 · see citing works

Transgenic Expression of the Shortest Human Tau Affects Its Compartmentalization and Its Phosphorylation as in the Pretangle Stage of Alzheimer's Disease

Brion, J., Tremp, G. L., & Octave, J. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65272-8 · Cited by 197 · see citing works

Gephyrin Interacts with Dynein Light Chains 1 and 2, Components of Motor Protein Complexes

Fuhrmann, J. C., Kins, S., Rostaing, P., Far, O. E., Kirsch, J., Sheng, M., Triller, A., Betz, H., & Kneussel, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05393.2002 · Cited by 191 · see citing works

KIFC2 Is a Novel Neuron-Specific C-Terminal Type Kinesin Superfamily Motor for Dendritic Transport of Multivesicular Body-Like Organelles

Saito, N., Okada, Y., Noda, Y., Kinoshita, Y., Kondo, S., & Hirokawa, N. (1997) · Neuron · doi:10.1016/s0896-6273(00)81243-x · Cited by 168 · see citing works

The β-Propensity of Tau Determines Aggregation and Synaptic Loss in Inducible Mouse Models of Tauopathy

Eckermann, K., Mocanu, M.-M., Khlistunova, I., Biernat, J., Nissen, A., Hofmann, A., Schönig, K., Bujard, H., Haemisch, A., Mandelkow, E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705282200 · Cited by 168 · see citing works

Swimming against the Tide: Mobility of the Microtubule-Associated Protein Tau in Neurons

Konzack, S., Thies, E., Marx, A., Mandelkow, E., & Mandelkow�, E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0927-07.2007 · Cited by 157 · see citing works

The role of tau phosphorylation and cleavage in neuronal cell death

Chun, W. (2006) · Frontiers in bioscience · doi:10.2741/2097 · Cited by 142 · see citing works

Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture

Zempel, H., Dennissen, F. J. A., Kumar, Y., Luedtke, J., Biernat, J., Mandelkow, E., & Mandelkow�, E. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.784702 · Cited by 139 · see citing works

The six brain‐specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes

Buchholz, S., & Zempel, H. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13784 · Cited by 145 · see citing works

Normal and Pathological Tau Proteins as Factors for Microtubule Assembly

Delacourte, A., & Buée, L. (1997) · International review of cytology · doi:10.1016/s0074-7696(08)62588-7 · Cited by 136 · see citing works

Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases

Sferra, A., Nicita, F., & Bertini, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197354 · Cited by 132 · see citing works

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments

Levenga, J., Krishnamurthy, P., Rajamohamedsait, H. B., Wong, H., Franke, T. F., Cain, P., Sigurdsson, E. M., & Hoeffer, C. A. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-34 · Cited by 128 · see citing works

Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration

Ohlemacher, S. K., Sridhar, A., Xiao, Y., Hochstetler, A., Sarfarazi, M., Cummins, T., & Meyer, J. S. (2016) · Stem Cells · doi:10.1002/stem.2356 · Cited by 126 · see citing works

Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization

Tortosa, E., Adolfs, Y., Fukata, M., Pasterkamp, R. J., Kapitein, L. C., & Hoogenraad, C. C. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.042 · Cited by 120 · see citing works

Insights into T‐cell dysfunction in Alzheimer's disease

Dai, L., & Shen, Y. (2021) · Aging Cell · doi:10.1111/acel.13511 · Cited by 119 · see citing works

Transgenic zebrafish model of neurodegeneration

Tomasiewicz, H. G., Flaherty, D. B., Soria, J., & Wood, J. G. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10451 · Cited by 116 · see citing works

Tau and Axonopathy in Neurodegenerative Disorders

Higuchi, M., Lee, V. M.-Y., & Trojanowski, J. Q. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:131 · Cited by 134 · see citing works

The ‘jaws’ model of tau-microtubule interaction examined in CHO cells

Preuß, U., Biernat, J., Mandelkow�, E., & Mandelkow�, E. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.6.789 · Cited by 108 · see citing works

Neonatal neuronal overexpression of glycogen synthase kinase-3β reduces brain size in transgenic mice

Spittaels, K., den Haute, C. V., Dorpe, J. V., Terwel, D., Vandezande, K., Lasrado, R., Bruynseels, K., Irizarry, M. C., Verhoye, M., Lint, J. V., et al. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00236-1 · Cited by 103 · see citing works

Pathological Changes of Tau Related to Alzheimer’s Disease

Chu, D., & Liu, F. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00457 · Cited by 103 · see citing works

Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis

Pallas‐Bazarra, N., Jurado‐Arjona, J., Navarrete, M., Esteban, J. A., Hernández, F., Ávila, J., & Llorens‐Martín, M. (2016) · The EMBO Journal · doi:10.15252/embj.201593518 · Cited by 101 · see citing works

Transport and diffusion of Tau protein in neurons

Scholz, T., & Mandelkow�, E. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1610-7 · Cited by 99 · see citing works

A functional role for intrinsic disorder in the tau-tubulin complex

Melo, A. M., Coraor, J., Cobb, G., Elbaum‐Garfinkle, S., Nath, A., & Rhoades, E. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610137113 · Cited by 93 · see citing works

The slow axonal transport of cytoskeletal proteins

Nixon, R. A. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80090-2 · Cited by 90 · see citing works

Tau's role in the developing brain: implications for intellectual disability

Sapir, T., Frotscher, M., Levy, T., Mandelkow, E., & Reiner, O. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr603 · Cited by 89 · see citing works

Making sense of the multiple MAP-2 transcripts and their role in the neuron

Shafit-Zagardo, B., & Kalcheva, N. (1998) · Molecular Neurobiology · doi:10.1007/bf02740642 · Cited by 89 · see citing works

Neural stem cell therapy for neurovascular injury in Alzheimer's disease

Boese, A. C., Hamblin, M. H., & Lee, J. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113112 · Cited by 88 · see citing works

Regulation of neuronal cytoskeleton by lysophosphatidic acid: role of GSK-3

Sayas, C. L. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00149-x · Cited by 81 · see citing works

Phosphorylation by CDK1 regulates XMAP215 function in vitro

Vasquez, R., Gard, D. L., & Cassimeris, L. (1999) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(1999)43:4 · Cited by 80 · see citing works

Dynamic integration of subplate neurons into the cortical barrel field circuitry during postnatal development in the Golli‐tau‐eGFP (GTE) mouse

Piñon, M. C., Jethwa, A., Jacobs, E. C., Campagnoni, A. T., & Molnár, Z. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.167767 · Cited by 77 · see citing works

Flavonoids as an Intervention for Alzheimer’s Disease: Progress and Hurdles Towards Defining a Mechanism of Action

Hole, K. L., & Williams, R. J. (2020) · Brain Plasticity · doi:10.3233/bpl-200098 · Cited by 78 · see citing works

Human tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ

Hall, G. F., Yao, J., & Lee, G. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4733 · Cited by 75 · see citing works

The Seaweed Diet in Prevention and Treatment of the Neurodegenerative Diseases

Pereira, L., & Valado, A. (2021) · Marine Drugs · doi:10.3390/md19030128 · Cited by 68 · see citing works

Microtubule Binding and Trapping at the Tip of Neurites Regulate Tau Motion in Living Neurons

Weissmann, C., Reyher, H.-J., Gauthier‐Kemper, A., Steinhoff, H., Junge, W., & Brandt, R. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00977.x · Cited by 68 · see citing works

Differentiation of human adult skin‐derived neuronal precursors into mature neurons

Gingras, M., Champigny, M., & Berthod, F. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20889 · Cited by 68 · see citing works

Manganese Induces Tau Hyperphosphorylation through the Activation of ERK MAPK Pathway in PC12 Cells

Cai, T., Che, H., Yao, T. S., Chen, Y., Huang, C., Zhang, W., Du, K., Zhang, J., Cao, Y., Chen, J., et al. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq308 · Cited by 67 · see citing works

Microtubule-associated protein 2 (MAP2) associates with the NMDA receptor and is spatially redistributed within rat hippocampal neurons after oxygen-glucose deprivation

Buddle, M., Eberhardt, E. S., Ciminello, L. H., Levin, T., Wing, R. A., DiPasquale, K., & Raley‐Susman, K. M. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02758-6 · Cited by 67 · see citing works

Protein Tau: Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease

Crespo‐Biel, N., Theunis, C., & LEUVEN, F. V. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/251426 · Cited by 64 · see citing works

Tau and Membranes: Interactions That Promote Folding and Condensation

Sallaberry, C. A., Voss, B. J., Majewski, J. P., Biernat, J., Mandelkow�, E., Chi, E. Y., & Zanden, C. M. V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725241 · Cited by 60 · see citing works

Protein with tau-like repeats regulates neuronal integrity and lifespan inC. elegans

Chew, Y. L., Fan, X., Götz, J., & Nicholas, H. (2013) · Journal of Cell Science · doi:10.1242/jcs.jcs124404 · Cited by 59 · see citing works

Neuroprotective activities of natural products from marine macroalgae during 1999–2015

Alghazwi, M., Kan, Y. Q., Zhang, W., Gai, W. P., Garson, M. J., & Smid, S. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0908-2 · Cited by 58 · see citing works

Analytical performance of reagent for assaying tau protein in human plasma and feasibility study screening neurodegenerative diseases

Yang, S., Chiu, M., Chen, T., Lin, C., Jeng, J., Tang, S., Lee, Y.-F., Yang, C., Liu, B.-H., Chen, H.-H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09009-3 · Cited by 58 · see citing works

Upregulation of MAP1B and MAP2 in the Rat Brain after Middle Cerebral Artery Occlusion: Effect of Age

Popa‐Wagner, A., Schröder, E., Schmoll, H., Walker, L. C., & Kessler, C. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199904000-00008 · Cited by 57 · see citing works

Polarity-Regulating Kinase Partitioning-Defective 1/Microtubule Affinity-Regulating Kinase 2 Negatively Regulates Development of Dendrites on Hippocampal Neurons

Terabayashi, T., Itoh, T. J., Yamaguchi, H., Yoshimura, Y., Funato, Y., Ohno, S., & Miki, H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3986-07.2007 · Cited by 51 · see citing works

Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells

Wang, L., Jiang, Q., Chu, J., Lin, L., Li, X.-G., Chai, G.-S., Wang, Q., Wang, J.-Z., & Tian, Q. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076057 · Cited by 47 · see citing works

Morphologically distinct plaque types differentially affect dendritic structure and organisation in the early and late stages of Alzheimer's disease

Adlard, P. A., & Vickers, J. C. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0476-6 · Cited by 47 · see citing works

The tau proteins in neuronal growth and development

Brandt, R. (1996) · Frontiers in bioscience · doi:10.2741/a120 · Cited by 47 · see citing works

Tau and Tauopathies

Robert, M., & Mathuranath, P. S. (2007) · Neurology India · doi:10.4103/0028-3886.30420 · Cited by 45 · see citing works

One axon, many kinesins: What's the logic?

Mureşan, V. (2000) · Journal of Neurocytology · doi:10.1023/a:1010943424272 · Cited by 44 · see citing works

Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy

Forrest, S. L., Lee, S., Nassir, N., Martínez-Valbuena, I., Sackmann, V., Li, J., Ahmed, A., Tartaglia, M. C., Ittner, L. M., Lang, A. E., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02604-x · Cited by 44 · see citing works

Cytoskeletal changes correlated with the loss of neuronal polarity in axotomized lamprey central neurons

Hall, G., Yao, J., Selzer, M. E., & Kosik, K. S. (1997) · Journal of Neurocytology · doi:10.1023/a:1018562331003 · Cited by 41 · see citing works

Tau target identification reveals NSF‐dependent effects on AMPA receptor trafficking and memory formation

Prikas, E., Parić, E., Asih, P. R., Stefanoska, K., Stefen, H., Fath, T., Poljak, A., & Ittner, A. (2022) · The EMBO Journal · doi:10.15252/embj.2021110242 · Cited by 39 · see citing works

JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination

Komulainen, E., Zdrojewska, J., Freemantle, E., Mohammad, H., Kulesskaya, N., Deshpande, P., Marchisella, F., Mysore, R., Hollós, P., Michelsen, K. A., et al. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00272 · Cited by 38 · see citing works

Biochemical Distribution of Tau Protein in Synaptosomal Fraction of Transgenic Mice Expressing Human P301L Tau

Sahara, N., Murayama, M., Higuchi, M., Suhara, T., & Takashima, A. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00026 · Cited by 37 · see citing works

SMN, Gemin2 and Gemin3 Associate with β-Actin mRNA in the Cytoplasm of Neuronal Cells In Vitro

Todd, A. G., Morse, R., Shaw, D. J., McGinley, S., Stebbings, H., & Young, P. J. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.06.058 · Cited by 37 · see citing works

Dendritic/Post-synaptic Tau and Early Pathology of Alzheimer’s Disease

Yin, X., Zhao, C., Qiu, Y., Zhou, Z., Bao, J., & Qian, W. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.671779 · Cited by 39 · see citing works

Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast‐Induced Traumatic Brain Injury

Du, X., West, M., Cheng, W., Ewert, D. L., Li, W., Saunders, D., Towner, R. A., Floyd, R. A., & Kopke, R. D. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4159357 · Cited by 35 · see citing works

A potential therapeutic effect of saikosaponin C as a novel dual‐target anti‐Alzheimer agent

Lee, T. H., Park, S., You, M., Lim, J.-H., Min, S., & Kim, B. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13515 · Cited by 36 · see citing works

Defective axonal transport in motor neuron disease

El‐Kadi, A. M., Soura, V., & Hafezparast, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21188 · Cited by 34 · see citing works

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems

Balaji, V., Kaniyappan, S., Mandelkow�, E., Wang, Y., & Mandelkow, E.-M. (2018) · Autophagy · doi:10.1080/15548627.2018.1509607 · Cited by 32 · see citing works

Expanding the cerebrospinal fluid endopeptidome

Hansson, K. T., Skillbäck, T. B., Pernevik, E., Kern, S., Portelius, E., Höglund, K., Brinkmalm, G., Holmén‐Larsson, J., Blennow, K., Zetterberg, H., et al. (2017) · PROTEOMICS · doi:10.1002/pmic.201600384 · Cited by 32 · see citing works

Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway

Kim, H. S., Yumkham, S., Kim, S., Yea, K., Shin, Y. C., Ryu, S. H., & Suh, P. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.10 · Cited by 32 · see citing works

The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia

Moll, L., & Schubert, M. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/384094 · Cited by 30 · see citing works

In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau

Zhang, S., Wang, C., Lu, J., Ma, X., Liu, Z., Li, D., Liu, Z., & Liu, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010090 · Cited by 31 · see citing works

Functional significance of O-GlcNAc modification in regulating neuronal properties

Hwang, H., & Rhim, H. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.006 · Cited by 30 · see citing works

Induction of mice adult bone marrow mesenchymal stem cells into functional motor neuron-like cells

Abdullah, R. H., Yaseen, N. Y., Salih, S. M., Al-Juboory, A. A., Hassan, A., & Al-Shammari, A. M. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.07.003 · Cited by 29 · see citing works

Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau

Ma, X., Zhu, Y., Lu, J., Xie, J., Li, C. V., Shin, W. S., Qiang, J., Liu, J., Dou, S., Xiao, Y., et al. (2020) · eLife · doi:10.7554/elife.51859 · Cited by 29 · see citing works

Polarized trafficking: the palmitoylation cycle distributes cytoplasmic proteins to distinct neuronal compartments

Tortosa, E., & Hoogenraad, C. C. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.02.004 · Cited by 29 · see citing works

Mechanisms of Axonal Sorting of Tau and Influence of the Axon Initial Segment on Tau Cell Polarity

Zempel, H., & Mandelkow�, E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9358-8_6 · Cited by 28 · see citing works

The Accumulation of Tau in Postsynaptic Structures: A Common Feature in Multiple Neurodegenerative Diseases?

Teravskis, P. J., Ashe, K. H., & Liao, D. (2020) · The Neuroscientist · doi:10.1177/1073858420916696 · Cited by 28 · see citing works

The Homologous Carboxyl-Terminal Domains of Microtubule-Associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles

Xie, C., Miyasaka, T., Yoshimura, S., Hatsuta, H., Yoshina, S., Kage-Nakadai, E., Mitani, S., Murayama, S., & Ihara, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089796 · Cited by 28 · see citing works

Wireless In Situ Catalytic Electron Signaling‐Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas

Iao, H. M., Chen, C., Lin, Y., Pan, W., Liang, C., Liu, H., Ching, L., Weng, P., Chiang, M., Hsu, R., et al. (2025) · Advanced Science · doi:10.1002/advs.202504786 · Cited by 28 · see citing works

Brain plasticity: to what extent do aged animals retain the capacity to coordinate gene activity in response to acute challenges

Popa‐Wagner, A., Schmoll, H., Badan, I., Platt, D., & Kessler, C. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00154-6 · Cited by 27 · see citing works

Enhanced Tau Protein Translation by Hyper-Excitation

Kobayashi, S., Tanaka, T., Soeda, Y., & Takashima, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00322 · Cited by 22 · see citing works

Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage

Kuboyama, T., Lee, Y., Nishiko, H., & Tohda, C. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.005 · Cited by 26 · see citing works

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice

Gilley, J., Ando, K., Seereeram, A., Rodríguez-Martín, T., Pooler, A. M., Sturdee, L., Anderton, B. H., Brion, J., Hanger, D. P., & Coleman, M. P. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.11.028 · Cited by 25 · see citing works

Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons.

Okabe, S., & Hirokawa, N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.4127 · Cited by 61 · see citing works

The role of microtubule associated proteins in the maturation of nerve processes Final report

Ginzburg, I., & Kirsch, J. (1997) · OpenGrey (Institut de l'Information Scientifique et Technique)

Sorting mechanisms of Tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding

Kanai, Y., & Hirokawa, N. (1995) · Neuron · doi:10.1016/0896-6273(95)90298-8 · Cited by 144 · see citing works

Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture

Caceres, A., Banker, G., & Binder, L. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00714.1986 · Cited by 367 · see citing works

An immunocytochemical analysis of the ontogeny of the microtubule-associated proteins MAP-2 and Tau in the nervous system of the rat

Ferreira, A., Busciglio, J. A., & Cáceres, A. (1987) · Developmental Brain Research · doi:10.1016/0165-3806(87)90191-x · Cited by 86 · see citing works