RUNX1/AML1: A Central Player in Hematopoiesis
Abstract
It has been well established that a number of transcription factors play critical roles in regulating the fate of hematopoietic stem cell populations. One of them is the leukemia-associated transcription factor acute myeloid leukemia 1 (AML1; also known as runt-related transcription factor 1, or RUNX1). This gene was originally cloned from the breakpoint of the t(8;21) reciprocal chromosome translocation and was later recognized as one of the most frequent targets of leukemia-associated gene aberrations. Gene-targeting experiments revealed that transcriptionally active AML1 is essential for the establishment of definitive hematopoiesis. More specifically, this gene functions in the emergence of the hematopoietic progenitor cells from the hemogenic endothelium by budding in the aorta-gonad-mesonephros region, and its expression points to the sites with strong potential for the emergence of hematopoietic stem cells. This review discusses aspects of the biologic properties of AML1 in early hematopoietic development.
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RUNX1 is a critical regulator of haematopoiesis that frequently participates in leukaemia-associated gene aberrations, including RUNX1-RUNX1T1 fusion recurrent in myeloid malignancies.
“RUNX1 is a critical regulator of haematopoiesis that frequently participates in leukaemia-associated gene aberrations, including the RUNX1–RUNX1T1 (AML1–ETO9a) fusion recurrent in myeloid malignancies.44”
From Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia (2018) · cites this paper as [44]
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- Authors
- Okuda, T., Nishimura, M., Nakao, M., & Fujitaa, Y.
- Affiliations
- Kyoto Prefectural University of Medicine (JP)
- Corresponding author
- Okuda, Tsukasa
- Venue
- International Journal of Hematology
- Published
- 2001-10
- Volume
- 74
- Issue
- 3
- Pages
- 252-257
- ISSN
- 0925-5710 (ISSN-L)
- 1865-3774
- OpenAlex
- W1982012088
- Cited by
- 118
- References
- 48
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 10 · 2019: 12 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Hematology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- RUNX1, hematopoiesis, hematopoietic stem cells, hematopoietic progenitor cells, hemogenic endothelium, aorta-gonad-mesonephros, transcription factors, definitive hematopoiesis, gene targeting
- MeSH terms
- Animals, DNA-Binding Proteins, Hematopoiesis, Hematopoietic Stem Cells, Humans, Proto-Oncogene Proteins, Transcription Factors, Neovascularization, Physiologic, Core Binding Factor Alpha 2 Subunit
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