Regulation and characteristics of vascular smooth muscle cell phenotypic diversity

Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease

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Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

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The smooth muscle cell in culture

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TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

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Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor

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Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members

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Serum response factor: toggling between disparate programs of gene expression

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Mechanisms of TGF-β signaling in regulation of cell growth and differentiation

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Formation of Hyaluronan- and Versican-Rich Pericellular Matrix Is Required for Proliferation and Migration of Vascular Smooth Muscle Cells

Evanko, S. P., Angello, J. C., & Wight, T. N. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.1004 · Cited by 487

Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis.

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Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth muscle cells.

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Arterial Smooth Muscle Cell Heterogeneity: Implications for Atherosclerosis and Restenosis Development

Hao, H., Gabbiani, G., & Bochaton-Piallat, M.-L. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000090130.85752.ed · Cited by 381

A Transforming Growth Factor β (TGFβ) Control Element Drives TGFβ-induced Stimulation of Smooth Muscle α-Actin Gene Expression in Concert with Two CArG Elements

Hautmann, M. B., Madsen, C. S., & Owens, G. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10948 · Cited by 304

Signal Transduction of Mechanical Stresses in the Vascular Wall

Lehoux, S., & Tedgui, A. (1998) · Hypertension · doi:10.1161/01.hyp.32.2.338 · Cited by 298

cDNA cloning of a myosin heavy chain isoform in embryonic smooth muscle and its expression during vascular development and in arteriosclerosis

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Mechanical Strain–Induced Extracellular Matrix Production by Human Vascular Smooth Muscle Cells: Role of TGF-β 1

O’Callaghan, C. J., & Williams, B. (2000) · Hypertension · doi:10.1161/01.hyp.36.3.319 · Cited by 286

Adhesion receptors of vascular smooth muscle cells and their functions

Moiseeva, E. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00399-6 · Cited by 282

Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo.

Frid, M. G., Moiseeva, E. P., & Stenmark, K. R. (1994) · Circulation Research · doi:10.1161/01.res.75.4.669 · Cited by 249

Mechanical Strain Increases Smooth Muscle and Decreases Nonmuscle Myosin Expression in Rat Vascular Smooth Muscle Cells

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Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury

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From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db‐cAMP in vitro differentiation model

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Smooth Muscle Cell Origin and Its Relation to Heterogeneity in Development and Disease

Groot, A. C. G.-D., DeRuiter, M. C., Bergwerff, M., & Poelmann, R. E. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.7.1589 · Cited by 231

Phenotypic Heterogeneity of Rat Arterial Smooth Muscle Cell Clones

Bochaton‐Piallat, M., Ropraz, P., Gabbiani, F., & Gabbiani, G. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.6.815 · Cited by 210

Smooth Muscle Cells Isolated From Discrete Compartments of the Mature Vascular Media Exhibit Unique Phenotypes and Distinct Growth Capabilities

Frid, M. G., Aldashev, A. A., Dempsey, E. C., & Stenmark, K. R. (1997) · Circulation Research · doi:10.1161/01.res.81.6.940 · Cited by 207

Altered response of vascular smooth muscle cells to exogenous biochemical stimulation in two- and three-dimensional culture

Stegemann, J. P., & Nerem, R. M. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00041-1 · Cited by 205

Stretch affects phenotype and proliferation of vascular smooth muscle cells

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Transforming growth factor-β1 signaling contributes to development of smooth muscle cells from embryonic stem cells

Sinha, S., Hoofnagle, M. H., Kingston, P. A., McCanna, M. E., & Owens, G. K. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00221.2004 · Cited by 203

Heterogeneity of Smooth Muscle Cell Populations Cultured From Pig Coronary Artery

Hao, H., Ropraz, P., Verin, V. E., Camenzind, E., Geinoz, A., Pepper, M. S., Gabbiani, G., & Bochaton‐Piallat, M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000022407.91111.e4 · Cited by 166

Mechanisms of Neointima Formation and Remodeling in the Porcine Coronary Artery

Christen, T., Verin, V., Bochaton-Piallat, M.-L., Popowski, Y., Ramaekers, F., Debruyne, P., Camenzind, E., van Eys, G., & Gabbiani, G. (2001) · Circulation · doi:10.1161/01.cir.103.6.882 · Cited by 160

Innate Diversity of Adult Human Arterial Smooth Muscle Cells

Li, S., Fan, Y., Chow, L. H., Diepstraten, C. V. D., van der Veer, E., Sims, S. M., & Pickering, J. G. (2001) · Circulation Research · doi:10.1161/hh1801.097165 · Cited by 157

Fibronectin and the basement membrane components laminin and collagen type IV influence the phenotypic properties of subcultured rat aortic smooth muscle cells differently

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Overexpression of Hyaluronan in the Tunica Media Promotes the Development of Atherosclerosis

Chai, S., Chai, Q., Danielsen, C. C., Hjorth, P., Nyengaard, J. R., Ledet, T., Yamaguchi, Y., Rasmussen, L. M., & Wogensen, L. (2005) · Circulation Research · doi:10.1161/01.res.0000158963.37132.8b · Cited by 143

Genomic analysis of smooth muscle cells in three‐dimensional collagen matrix

Li, S., Lao, J., Chen, B. P. C., Li, Y., Zhao, Y., Chu, J. S. F., Chen, K., Tsou, T., Peck, K., & Chien, S. (2002) · The FASEB Journal · doi:10.1096/fj.02-0256fje · Cited by 134

Cultured Porcine Coronary Artery Smooth Muscle Cells

Christen, T., Bochaton‐Piallat, M., Neuville, P., Rensen, S. S., Redard, M., van Eys, G. J. J. M., & Gabbiani, G. (1999) · Circulation Research · doi:10.1161/01.res.85.1.99 · Cited by 132

Evidence From a Novel Human Cell Clone That Adult Vascular Smooth Muscle Cells Can Convert Reversibly Between Noncontractile and Contractile Phenotypes

Li, S., Sims, S. M., Jiao, Y., Chow, L. H., & Pickering, J. G. (1999) · Circulation Research · doi:10.1161/01.res.85.4.338 · Cited by 130

ERK1/2 mediates PDGF-BB stimulated vascular smooth muscle cell proliferation and migration on laminin-5

Kingsley, K., Huff, J. L., Rust, W. L., Carroll, K. J., Martı́nez, A., Fitchmun, M. I., & Plopper, G. E. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00331-5 · Cited by 101

Increased Intimal Hyperplasia and Smooth Muscle Cell Proliferation in Transgenic Mice With Heparan Sulfate–Deficient Perlecan

Tran, P.-K., Tran‐Lundmark, K., Soininen, R., Tryggvason, K., Thyberg, J., & Hedin, U. (2004) · Circulation Research · doi:10.1161/01.res.0000117772.86853.34 · Cited by 100

Activation of JNK/SAPK and ERK by Mechanical Strain in Vascular Smooth Muscle Cells Depends on Extracellular Matrix Composition

Reusch, H. P., Chan, G., Ives, H. E., & Nemenoff, R. A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7121 · Cited by 99

Dominant Negative Murine Serum Response Factor: Alternative Splicing within the Activation Domain Inhibits Transactivation of Serum Response Factor Binding Targets

Belaguli, N. S., Zhou, W., Trinh, T.-H. T., Majesky, M. W., & Schwartz, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4582 · Cited by 96

The Extracellular Matrix Dynamically Regulates Smooth Muscle Cell Responsiveness to PDGFa

Raines, E. W., Koyama, H., & Carragher, N. O. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06299.x · Cited by 95

all- Trans -Retinoic Acid Reduces Neointimal Formation and Promotes Favorable Geometric Remodeling of the Rat Carotid Artery After Balloon Withdrawal Injury

Miano, J. M., Kelly, L. A., Artacho, C. A., Nuckolls, T. A., Piantedosi, R., & Blaner, W. S. (1998) · Circulation · doi:10.1161/01.cir.98.12.1219 · Cited by 93

Fibrillar Collagen Specifically Regulates Human Vascular Smooth Muscle Cell Genes Involved in Cellular Responses and the Pericellular Matrix Environment

Ichii, T., Koyama, H., Tanaka, S., Kim, S., Shioi, A., Okuno, Y., Raines, E. W., Iwao, H., Otani, S., & Nishizawà, Y. (2001) · Circulation Research · doi:10.1161/01.res.88.5.460 · Cited by 89

Intraluminal Pressure Is Essential for the Maintenance of Smooth Muscle Caldesmon and Filamin Content in Aortic Organ Culture

Birukov, K. G., Bardy, N., Lehoux, S., et al. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.6.922 · Cited by 81

Cellular retinol-binding protein-1 is expressed by distinct subsets of rat arterial smooth muscle cells in vitro and in vivo.

Neuville, P., Geinoz, A., Benzonana, G., Redard, M., Gabbiani, F., Ropraz, P., & Gabbiani, G. (1997) · Europe PMC (PubMed Central) · Cited by 79

Endogenous Retinoic Acid Signaling Colocalizes With Advanced Expression of the Adult Smooth Muscle Myosin Heavy Chain Isoform During Development of the Ductus Arteriosus

Colbert, M. C., Kirby, M. L., & Robbins, J. M. (1996) · Circulation Research · doi:10.1161/01.res.78.5.790 · Cited by 77

Insulin Receptor Substrate-1/SHP-2 Interaction, a Phenotype-dependent Switching Machinery of Insulin-like Growth Factor-I Signaling in Vascular Smooth Muscle Cells

Hayashi, K., Shibata, K., Morita, T., Iwasaki, K., Watanabe, M., & Sobue, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405100200 · Cited by 72

Heparan Sulfate Proteoglycans Mediate a Potent Inhibitory Signal for Migration of Vascular Smooth Muscle Cells

Koyama, N., Kinsella, M. G., Wight, T. N., Hedin, U., & Clowes, A. W. (1998) · Circulation Research · doi:10.1161/01.res.83.3.305 · Cited by 70

Retinoic acid uses divergent mechanisms to activate or suppress mitogenesis in rat aortic smooth muscle cells.

Chen, S., & Gardner, D. G. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3483 · Cited by 67

Suppression of smooth-muscle α-actin expression by platelet-derived growth factor in vascular smooth-muscle cells involves Ras and cytosolic phospholipase A2

Xiaomei, L. I., Putten, V. V., Zarinetchi, F., NICKS, E. M., Thaler, S., HEASLEY, E. L., & NEMENOFF, A. R. (1997) · Biochemical Journal · doi:10.1042/bj3270709 · Cited by 60

Angiotensin II Induces Phenotype-Dependent Apoptosis in Vascular Smooth Muscle Cells

Bascands, J., Girolami, J., Troly, M., Escargueil‐Blanc, I., Nazzal, D., Salvayre, R., & Blaes, N. (2001) · Hypertension · doi:10.1161/hy1201.096540 · Cited by 56

Cell Surface-bound Collagenase-1 and Focal Substrate Degradation Stimulate the Rear Release of Motile Vascular Smooth Muscle Cells

Li, S., Chow, L. H., & Pickering, J. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005139200 · Cited by 49

Adenoviral Activin A Expression Prevents Intimal Hyperplasia in Human and Murine Blood Vessels by Maintaining the Contractile Smooth Muscle Cell Phenotype

Engelse, M. A., Lardenoye, J.-W. H. P., Neele, J. M., Grimbergen, J. M., de Vries, M. R., Lamfers, M. L. M., Pannekoek, H., Quax, P. H. A., & de Vries, C. J. M. (2002) · Circulation Research · doi:10.1161/01.res.0000021044.53156.f5 · Cited by 42

Analysis of TGF-β-Mediated Synthesis of Extracellular Matrix Components

Hocevar, B. A., & Howe, P. H. (2003) · Humana Press eBooks · doi:10.1385/1-59259-053-5:55 · Cited by 42

Chimeric DNA–RNA hammerhead ribozyme targeting PDGF A-chain mRNA specifically inhibits neointima formation in rat carotid artery after balloon injury

Kotani, M., Fukuda, N., Ando, H., Hu, W.-Y., Kunimoto, S., Saito, S., & Kanmatsuse, K. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00607-7 · Cited by 32

Cultured Arterial Smooth Muscle Cells Maintain Distinct Phenotypes When Implanted Into Carotid Artery

Bochaton‐Piallat, M., Clowes, A. W., Clowes, M. M., Fischer, J. W., Redard, M., Gabbiani, F., & Gabbiani, G. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.949 · Cited by 29

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Depuydt, M. A. C., Prange, K. H. M., Slenders, L., Örd, T., Elbersen, D., Boltjes, A., de Jager, S. C. A., Asselbergs, F. W., de Borst, G. J., Aavik, E., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316770 · Cited by 594

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models

Chappell, J., Harman, J. L., Narasimhan, V. M., Yu, H., Foote, K., Simons, B. D., Bennett, M. R., & Jørgensen, H. F. (2016) · Circulation Research · doi:10.1161/circresaha.116.309799 · Cited by 437

Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation: Involvement of Vitamin K-Dependent Processes

Petsophonsakul, P., Furmanik, M., Forsythe, R., Dweck, M., Schurink, G. W., Natour, E., Reutelingsperger, C., Jacobs, M., Mees, B., & Schurgers, L. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.312787 · Cited by 341

Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation

Sorokin, V., Vickneson, K., Kofidis, T., Woo, C. C., Lin, X. Y., Foo, R., & Shanahan, C. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599415 · Cited by 292

A biomimetic hydrogel based on methacrylated dextran-graft-lysine and gelatin for 3D smooth muscle cell culture

Liu, Y., & Chan-Park, M. B. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.040 · Cited by 285