Ovarian steroids modulate neuroendocrine dysfunction in polycystic ovary syndrome

Doi, S. A. R.; Al-Zaid, M.; Towers, P. A.; Scott, C. J.; Al-Shoumer, K. A. S.

doi:10.1007/bf03345319

Cited by 26Ovarian function and disordersHypothalamic control of reproductive hormonesReproductive Biology and Fertility

Ovarian steroids modulate neuroendocrine dysfunction in polycystic ovary syndrome

Doi, S. A. R., Al-Zaid, M., Towers, P. A., Scott, C. J., Al-Shoumer, K. A. S.·2005·Journal of Endocrinological Investigation

DOI 10.1007/bf03345319

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Abstract

Objective Neuroendocrine dysfunction in polycystic ovary syndrome (PCOS) was addressed by studying the steroid hormone changes in women with PCOS with either high or normal LH levels leading to inferences regarding the primacy of elevated LH in the pathophysiology of PCOS.Methods A cross-sectional study was designed in an academic clinical facility involving 234 women with PCOS. Patients were divided into two groups based on an LH/FSH ratio < or >1 and hormonal and metabolic studies were performed in both groups. Factors were determined by binomial logistic regression that predicted group membership of these women.Results Higher follicular phase estradiol (E2) and androstenedione (A4) levels as well as greater insulin sensitivity were the only factors that predicted the presence of neuroendocrine dysfunction with elevated A4 being necessary for neuroendocrine dysfunction.Conclusions It was concluded that uncoupling of hypothalamic E2 inhibition by elevated ovarian A4 associated with E2 related sensitization of pituitary LH leads to neuroendocrine dysfunction in PCOS.

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Genetic and environmental contributors combine with obesity, ovarian dysfunction and hormonal drivers to contribute to the aetiology of PCOS.
“Genetic and environmental contributors combine with obesity, ovarian dysfunction and hormonal drivers to contribute to the aetiology of PCOS. 17,18”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [18]

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050 · see citing works
Clinical assessment of body hair growth in women.
Ferriman, D., & Gallwey, J. D. (1961) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem-21-11-1440 · Cited by 2,556 · see citing works
Men at risk: occupation and male infertility.
Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219 · see citing works
Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer Program
Lévy, J., Matthews, D. R., & Hermans, M. P. (1998) · Diabetes Care · doi:10.2337/diacare.21.12.2191 · Cited by 1,997 · see citing works
Effect of testosterone and estradiol in a man with aromatase deficiency
Carani, C., Qin, K., Simoni, M., Faustini-Fustini, M., Serpente, S., Boyd, J., Korach, K. S., & Simpson, E. R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370204 · Cited by 1,151 · see citing works
Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism.
Adams, J., POLSON, D. W., & Franks, S. (1986) · BMJ · doi:10.1136/bmj.293.6543.355 · Cited by 975 · see citing works
Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome
Legro, R. S., Driscoll, D., Strauss, J. F., Fox, J., & Dunaif, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14956 · Cited by 699 · see citing works
REVIEW ARTICLE: THE POLYCYSTIC OVARY SYNDROME
Yen, S. S. C. (1980) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1980.tb02132.x · Cited by 697 · see citing works
Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.
Rebar, R. W., Judd, H. L., Yen, S. S. C., Rakoff, J. S., Vandenberg, G., & Naftolin, F. N. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108400 · Cited by 615 · see citing works
Characterization of Groups of Hyperaiidrogenic Women with Acanthosis Nigricans, Impaired Glucose Tolerance, and/or Hyperinsulinemia*
Dunaif, A. E., GRAF, M., Mandeli, J., Laumas, V., & Dobrjansky, A. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-3-499 · Cited by 577 · see citing works
Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women with Polycystic Ovary Syndrome<sup>1</sup>
Ehrmann, D. A., Schneider, D. J., Sobel, B. E., Cavaghan, M. K., Imperial, J., Rosenfield, R. L., & Polonsky, K. S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4069 · Cited by 461 · see citing works
Detecting Insulin Resistance in Polycystic Ovary Syndrome: Purposes and Pitfalls
Legro, R. S., Castracane, V. D., & Kauffman, R. P. (2004) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000109523.25076.e2 · Cited by 453 · see citing works
Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features
Morales, A. J., Laughlin, G. A., Bützow, T. L., Maheshwari, H., Baumann, G., & Yen, S. S. C. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768842 · Cited by 453 · see citing works
Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries
Gilling‐Smith, C., Willis, D., Beard, R. W., & Franks, S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962289 · Cited by 436 · see citing works
A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom)
Conte, F. A., Grumbach, M. M., Ito, Y., Fisher, C. R., & Simpson, E. R. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.8200927 · Cited by 379 · see citing works
Polycystic Ovarian Syndrome: Evidence that Flutamide Restores Sensitivity of the Gonadotropin-Releasing Hormone Pulse Generator to Inhibition by Estradiol and Progesterone 1
Eagleson, C. A., Gingrich, M. B., Pastor, C. L., Arora, T. K., Solorzano, C. M. B., Evans, W. S., & Marshall, J. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6992 · Cited by 368 · see citing works
Repeatability Characteristics of Simple Indices of Insulin Resistance: Implications for Research Applications
Mather, K. J., Hunt, A. E., Steinberg, H. O., Paradisi, G., Hook, G., Katz, A., Quon, M. J., & Baron, A. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.7880 · Cited by 363 · see citing works
Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome
Gilling‐Smith, C., Story, H., Rogers, V., & Franks, S. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2321049.x · Cited by 301 · see citing works
Insulin Sensitivity and Its Measurement: Structural Commonalities among the Methods1
Radziuk, J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7025 · Cited by 289 · see citing works
Polycystic Ovarian Syndrome: Evidence that Flutamide Restores Sensitivity of the Gonadotropin-Releasing Hormone Pulse Generator to Inhibition by Estradiol and Progesterone
Eagleson, C. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.11.4047 · Cited by 286 · see citing works
The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries
Robinson, S., Kiddy, D. S., Gelding, S. V., Willis, D., Niththyananthan, R., Bush, A., Johnston, D. G., & Franks, S. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02376.x · Cited by 282 · see citing works
Early Endocrine, Metabolic, and Sonographic Characteristics of Polycystic Ovary Syndrome (PCOS): Comparison between Nonobese and Obese Adolescents
Silfen, M. E., Denburg, M. R., Manibo, A. M., Lobo, R. A., Jaffe, R., Ferin, M., Levine, L. S., & Oberfield, S. E. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030617 · Cited by 269 · see citing works
Regulation of androgen production in cultured human thecal cells by insulin-like growth factor I and insulin
Bergh, C., Carlsson, B., Olsson, J., Selleskog, U., & Hillensjø, T. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55675-1 · Cited by 253 · see citing works
Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome
Gambineri, A., Pelusi, C., Genghini, S., Morselli‐Labate, A. M., Cacciari, M., Pagotto, U., & Pasquali, R. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.01973.x · Cited by 216 · see citing works
Hormonal Effects of Flutamide in Young Women with Polycystic Ovary Syndrome
Leo, V. D., Lanzetta, D., D’Antona, D., Marca, A. L., & Morgante, G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.1.4500 · Cited by 192 · see citing works
Inappropriate Gonadotropin Secretion in Polycystic Ovary Syndrome: Influence of Adiposity 1
Arroyo, A., Laughlin, G. A., Morales, A. J., & Yen, S. S. C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4377 · Cited by 188 · see citing works
Ambulatory blood pressure profiles and plasminogen activator inhibitor (PAI‐1) activity in lean women with and without the polycystic ovary syndrome
Sampson, M., Kong, C. H., Patel, A. K., Unwin, R. J., & Jacobs, H. S. (1996) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1996.00863.x · Cited by 184 · see citing works
The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women
Holte, J., Bergh, T., Gennarelli, G., & WIDE, L. E. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02578.x · Cited by 178 · see citing works
Hyperinsulinemia in polycystic ovary syndrome correlates with increased cardiovascular risk independent of obesity
Mather, K. J., Kwan, F., & Corenblum, B. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00468-9 · Cited by 177 · see citing works
Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations
Dale, P. O., Tanbo, T. G., Vaaler, S., & Åbyholm, T. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55249-2 · Cited by 176 · see citing works
Endocrine changes after laparoscopic ovarian cautery in polycystic ovarian syndrome
Greenblatt, E. M., & Casper, R. F. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(87)90268-7 · Cited by 161 · see citing works
The Impact of Obesity and Chronic Hyperinsulinemia on Gonadotropin Release and Gonadal Steroid Secretion in the Polycystic Ovary Syndrome*
Dunaif, A. E., Mandeli, J., Fluhr, H., & Dobrjansky, A. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-131 · Cited by 160 · see citing works
Effect of troglitazone on endocrine and ovulatory performance in women with insulin resistance–related polycystic ovary syndrome
Hasegawa, I., Murakawa, H., Suzuki, M., Yamamoto, Y., Kurabayashi, T., & Tanaka, K. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00454-3 · Cited by 156 · see citing works
Limitations of the Fasting Glucose to Insulin Ratio as an Index of Insulin Sensitivity
Quon, M. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7952 · Cited by 155 · see citing works
Insulin Resistance in Nonobese Patients with Polycystic Ovary Syndrome
Toprak, S., Yönem, A., Çakır, B., Güler, S., Azal, Ö., Özata, M., & Çorakçı, A. (2001) · Hormone Research in Paediatrics · doi:10.1159/000049972 · Cited by 152 · see citing works
Adult polycystic ovary syndrome begins in childhood
Franks, S. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0203 · Cited by 142 · see citing works
Inappropriate Gonadotropin Secretion in Polycystic Ovary Syndrome: Influence of Adiposity
Arroyo, A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.11.3728 · Cited by 140 · see citing works
Impact of Obesity on Insulin Action in Volunteers with Normal Glucose Tolerance: Demonstration of a Threshold for the Adverse Effect of Obesity*
CAMPBELL, P. J., & Gerich, J. E. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-4-1114 · Cited by 137 · see citing works
Strength-Duration Characteristics of Estrogen Effects on Gonadotropin Response to Gonadotropin-Releasing Hormone in Women. II. Effects of Varying Concentrations of Estradiol
YOUNG, J. R., & Jaffe, R. B. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-3-432 · Cited by 135 · see citing works
Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women With Polycystic Ovary Syndrome
Ehrmann, D. A., Schneider, D. J., Sobel, B. E., Cavaghan, M. K., Imperial, J., Rosenfield, R. L., & Polonsky, K. S. (1998) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199801000-00017 · Cited by 129 · see citing works
The Effects of Ovarian Wedge Resection on Circulating Gonadotropin and Ovarian Steroid Levels in Patients with Polycystic Ovary Syndrome
Judd, H. L., Rigg, L. A., Anderson, D. C., & Yen, S. S. C. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-2-347 · Cited by 111 · see citing works
Incidence of elevated LH/FSH ratio in polycystic ovary syndrome women with normo- and hyperinsulinemia.
Banaszewska, B., Spaczyński, R., Pelesz, M., & Pawelczyk, L. A. (2003) · PubMed · Cited by 103 · see citing works
Detection of LH Release from Individual Pituitary Cells by the Reverse Hemolytic Plaque Assay: Estrogen Increases the Fraction of Gonadotropes Responding to CnRH
SMITH, P. F., Frawley, L. S., & Neill, J. D. (1984) · Endocrinology · doi:10.1210/endo-115-6-2484 · Cited by 102 · see citing works
Polycystic ovaries in hirsute women with normal menses
Carmina, E., & Løbo, R. A. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00979-2 · Cited by 101 · see citing works
Do hyperandrogenic women with normal menses have polycystic ovary syndrome?
Carmina, E., & Løbo, R. A. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00455-5 · Cited by 100 · see citing works
Regulation of the preovulatory gonadotropin surge by endogenous steroids
Mahesh, V. B., & Brann, D. W. (1998) · Steroids · doi:10.1016/s0039-128x(98)00075-0 · Cited by 99 · see citing works
The polycystic ovary syndrome.
Rb, G., & Moreno Martinez, O. (1960) · PubMed · Cited by 92 · see citing works
Unexpected responses of the hypothalamic gonadotropin-releasing hormone "pulse generator" to physiological estradiol inputs in the absence of the ovary.
Kesner, J. S., Wilson, R. C., Kaufman, J., Hotchkiss, J., Chen, Y., Yamamoto, H., Pardo, R. R., & Knobil, E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8745 · Cited by 88 · see citing works
Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin- releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: evidence from GnRH agonist and human chorionic gonadotropin stimulation testing
Ibáñez, L., Hall, J. E., Potau, N., Carrascosa, A., Prat, N., & Taylor, A. E. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923867 · Cited by 85 · see citing works
Hypothalamic dysfunction
Marshall, J. C., Eagleson, C. A., & McCartney, C. R. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00611-6 · Cited by 79 · see citing works
Decreased release of gonadotropin-releasing hormone during the preovulatory midcycle luteinizing hormone surge in normal women.
Hall, J. E., Taylor, A. E., Martin, K. A., Rivier, J., Schoenfeld, D., & Crowley, W. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.6894 · Cited by 78 · see citing works
Effect of Acute Physiological Elevations of Insulin on Circulating Androgen Levels in Nonobese Women*
Diamond, M. P., GRAINGER, D. A., LAUDANO, A. J., Starick-Zych, K., & DeFronzo, R. A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-4-883 · Cited by 74 · see citing works
Roles of LH and insulin resistance in lean and obese polycystic ovary syndrome
Grulet, H., Hécart, A. C., Delemer, B., Gross, A., Sulmont, V., Leuténegger, M., & Caron, J. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02144.x · Cited by 73 · see citing works
The Effects of Continuous Androgen Secretion on the Hypothalamic-Pituitary Axis in Woman: Evidence from a Luteinized Thecoma of the Ovary
Dunaif, A. E., Scully, R. E., Andersen, R. N., Chapin, D. S., & Crowley, W. F. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-389 · Cited by 71 · see citing works
Relationship of GnRH‐stimulated LH release to episodic LH secretion and baseline endocrine‐metabolic measures in women with polycystic ovary syndrome
Patel, K. S., Coffler, M. S., Dahan, M. H., Malcom, P. J., Deutsch, R., & Chang, R. J. (2003) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.01945.x · Cited by 70 · see citing works
Increased Luteinizing Hormone Secretion in Women with Polycystic Ovary Syndrome Is Unaltered by Prolonged Insulin Infusion
Patel, K., Coffler, M. S., Dahan, M. H., Yoo, R. Y., Lawson, M. A., Malcom, P. J., & Chang, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030816 · Cited by 60 · see citing works
Use of a Gonadotropin-Releasing Hormone Antagonist as a Physiologic Probe in Polycystic Ovary Syndrome: Assessment of Neuroendocrine and Androgen Dynamics1
Hayes, F. J., Taylor, A. E., Martin, K. A., & Hall, J. E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.7.4925 · Cited by 58 · see citing works
PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic–pituitary–adrenal axis?
Doi, S. A. R., Towers, P. A., Scott, C., & Al-Shoumer, K. A. S. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.06.024 · Cited by 57 · see citing works
Self-citation
Irregular cycles and steroid hormones in polycystic ovary syndrome
Doi, S. A. R., Al-Zaid, M. M., Towers, P. A., Scott, C., & Al-Shoumer, K. A. S. (2005) · Human Reproduction · doi:10.1093/humrep/dei093 · Cited by 55 · see citing works
Self-citation
Insulin-sensitising agents in polycystic-ovary syndrome
Sattar, N. A., Hopkinson, Z. E., & Greer, I. A. (1998) · The Lancet · doi:10.1016/s0140-6736(05)78345-8 · Cited by 54 · see citing works
Mild adrenal and ovarian steroidogenic abnormalities in hirsute women without hyperandrogenemia: Does idiopathic hirsutism exist?
Escobar-Morreale, H. F., Gotarredona, J. S., García‐Robles, R., Sancho, J., & Varela, C. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90077-9 · Cited by 53 · see citing works
Should patients with polycystic ovarian syndrome be treated with metformin?
Seli, E. U. (2002) · Human Reproduction · doi:10.1093/humrep/17.9.2230 · Cited by 43 · see citing works
Use of a Gonadotropin-Releasing Hormone Antagonist as a Physiologic Probe in Polycystic Ovary Syndrome: Assessment of Neuroendocrine and Androgen Dynamics
Hayes, F. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.7.2343 · Cited by 34 · see citing works
The influence of luteinizing hormone and insulin on sex steroids and sex hormone-binding globulin in the polycystic ovarian syndrome
Buyalos, R. P., Geffner, M. E., Watanabe, R. M., Bergman, R. N., GORNBEIN, J. A., & Judd, H. L. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56212-8 · Cited by 33 · see citing works
Changes in luteinizing hormone and insulin secretion in polycystic ovarian syndrome
Fulghesu, A. M. (1999) · Human Reproduction · doi:10.1093/humrep/14.3.611 · Cited by 32 · see citing works
The Effects of the Aromatase Inhibitor A1-Testolactone on Gonadotropin Release and Steroid Metabolism in Polycystic Ovarian Disease*
Dunaif, A. E., Longcope, C., Canick, J. A., et al. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-4-773 · Cited by 30 · see citing works
Clinical and endocrinological effects of 6 months of metformin treatment in young hyperinsulinemic patients affected by polycystic ovary syndrome
Loverro, G., Lorusso, F., De Pergola, G., Nicolardi, V., Mei, L., & Selvaggi, L. (2002) · Gynecological Endocrinology · doi:10.1080/713603060 · Cited by 27 · see citing works
Variation of luteinizing hormone and androgens in oligomenorrhoea and its implications for the study of polycystic ovary syndrome
van Hooff, M. H. A., van der Meer, M., Lambalk, C. B., & Schoemaker, J. (1999) · Human Reproduction · doi:10.1093/humrep/14.7.1684 · Cited by 27 · see citing works
Idiopathic Hirsutism or Polycystic Ovary Syndrome?
Jahanfar, S., & Eden, J. (1993) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.1993.tb02125.x · Cited by 26 · see citing works
A pilot study of the human chorionic gonadotrophin test for ovarian hyperandrogenism
Levrant, S. G., Barnes, R. B., & Rosenfield, R. L. (1997) · Human Reproduction · doi:10.1093/humrep/12.7.1416 · Cited by 26 · see citing works
Endocrinology: The effect of flutamide on pulsatile gonadotrophin secretion in hyperandrogenaemic women
Sir‐Petermann, T., Rabenbauer, B., & Wildt, L. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137938 · Cited by 20 · see citing works
Dependence of Mean Levels of Circulating Luteinizing Hormone upon Pulsatile Amplitude and Frequency*
Kazer, R. R., LIU, C. H., & Yen, S. S. C. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-4-796 · Cited by 19 · see citing works
Different responses of insulin, C‐peptide, and testosterone to an oral glucose tolerance test in two groups of women with polycystic ovarian syndrome
Ke, W. X., Shan, G. Q., & Hua, S. Y. (1996) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349609033311 · Cited by 17 · see citing works
LH levels in women with polycystic ovarian syndrome: have modern assays made them irrelevant?
Milsom, S. R., Sowter, M. C., Carter, M. A., Knox, B. S., & Gunn, A. J. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2003.02528.x · Cited by 14 · see citing works
Gonadotropin levels in women with polycystic ovary syndrome: Their relationship to body weight and insulin levels
Tropeano, G., Vuolo, I. P., Lucisano, A., Liberale, I., Barini, A., Carfagna, P., Caroli, G., Menini, E., & Dell'Acqua, S. (1996) · Journal of Endocrinological Investigation · doi:10.1007/bf03349856 · Cited by 13 · see citing works
Can Polycystic Ovary Syndrome Exist Without Concomitant Hypothalamic Dysfunction?
Berga, S. L., & Daniels, T. L. (1997) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-1016298 · Cited by 7 · see citing works
Gonadotropin evaluation in the diagnosis of polycystic ovary syndrome using either a monoclonal or a polyclonal antibody radioimmunoassay
Manieri, C., Pastorino, R., Marolda, A., et al. (1992) · Journal of Endocrinological Investigation · doi:10.1007/bf03348715 · Cited by 6 · see citing works
[Do androgens modulate luteinizing hormone secretion in women?].
Sir, T. (1997) · PubMed · Cited by 3 · see citing works

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Teede, H., Deeks, A., & Moran, L. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-41 · Cited by 1,565 · see citing works
Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline
Teede, H. J., Misso, M. L., Deeks, A. A., Moran, L. J., Stuckey, B. G. A., Wong, J. L. A., Norman, R. J., Costello, M. F., & Groups, O. B. O. T. G. D. (2011) · Medical Journal of Australia · doi:10.5694/mja11.10915 · Cited by 379 · see citing works
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Martin, M. L., Halling, K., Eek, D., Krohe, M., & Paty, J. (2017) · Health and Quality of Life Outcomes · doi:10.1186/s12955-017-0736-3 · Cited by 40 · see citing works

Authors: Doi, S. A. R., Al-Zaid, M., Towers, P. A., Scott, C. J., & Al-Shoumer, K. A. S.
Affiliations: Mubarak Al Kabeer Hospital (KW)
Charles Sturt University (AU)
Corresponding author: Doi, S. A. R.
ORCID: Doi, S. A. R.
Scott, C. J.
Venue: Journal of Endocrinological Investigation
Publisher: Springer Science and Business Media LLC
Published: 2005-01
Volume: 28
Issue: 1
Pages: 882-892
ISSN: 0391-4097 (ISSN-L)
1720-8386
DOI: 10.1007/bf03345319
OpenAlex: W2063853955
Semantic Scholar: 4402dda27bbe6597db983fc2367afd55cb68889d
Cited by: 26
References: 78
Citations by year: 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 1 · 2013: 1 · 2012: 2
FWCI: 2.10
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Endocrinological Investigation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords: polycystic ovary syndrome, neuroendocrine dysfunction, luteinizing hormone, LH/FSH ratio, androstenedione, insulin sensitivity, hypothalamic-pituitary-gonadal axis, ovarian steroids
MeSH terms: Adolescent, Adult, Androstenedione, Blood Glucose, Cross-Sectional Studies, Estradiol, Female, Follicle Stimulating Hormone, Homeostasis, Humans, Hypothalamus, Insulin, Insulin Resistance, Luteinizing Hormone, Neurosecretory Systems, Obesity, Pituitary Gland, Polycystic Ovary Syndrome, Regression Analysis, Testosterone, Body Mass Index, 17-alpha-Hydroxyprogesterone

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Ovarian steroids modulate neuroendocrine dysfunction in polycystic ovary syndrome

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