Adult polycystic ovary syndrome begins in childhood
Abstract
Polycystic ovary syndrome (PCOS) frequently presents during adolescence and is the commonest cause of menstrual irregularity and hirsutism. The characteristic endocrine abnormalities include hypersecretion of androgens and LH. Metabolic dysfunction is also a feature of many young women with PCOS. Hyperinsulinaemia and insulin resistance, which can be regarded as an exaggeration of the normal metabolic changes that occur during puberty, are further amplified by obesity. The aetiology of PCOS is uncertain but there is evidence for a primary abnormality of ovarian androgen production which is manifest at puberty but may have its origins in childhood or even during fetal development.
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After 6 years of follow-up, 59% of adolescents who had presented with oligomenorrhea at the beginning of the study remained oligomenorrheic and fulfilled the criteria for polycystic ovary syndrome.
“Indeed, after 6 years of follow-up, 59% of the adolescents who had presented with oligomenorrhea at the beginning of the study remained oligomenorrheic and fulfilled the criteria for PCOS [70]”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [70]
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- Authors
- Franks, S.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Franks, Stephen
- ORCID
- Franks, Stephen
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 16
- Issue
- 2
- Pages
- 263-272
- ISSN
- 1521-690X (ISSN-L)
- OpenAlex
- W2140427591
- Cited by
- 142
- References
- 42
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 13 · 2014: 5 · 2013: 8 · 2012: 9
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- polycystic ovary syndrome, childhood onset, adolescent PCOS, menstrual irregularity, hirsutism, luteinizing hormone, hyperinsulinemia, insulin resistance, obesity, ovarian androgen production, puberty, fetal development, etiology
- MeSH terms
- Adolescent, Aging, Diagnosis, Differential, Female, Humans, Ovary, Polycystic Ovary Syndrome, Hyperandrogenism
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