CoChat
Sign Up
Cited by 42Adrenal and Paraganglionic TumorsPituitary Gland Disorders and TreatmentsAdrenal Hormones and Disorders

Response to radiation therapy in adrenocortical carcinoma

Hermsen, I. G. C., Groenen, Y. E., Dercksen, M. W., Theuws, J., Haak, H. R.·2010·Journal of Endocrinological Investigation
DOI 10.1007/bf03346675
Open this paper in CoChat — free account

Abstract

Introduction Adrenocortical carcinoma (ACC) is a rare disease which is considered resistant to many treatments. The role of radiotherapy in ACC remains unclear. In general radiotherapy is thought to be ineffective for the treatment of ACC, and therefore not often used. However, recent reports suggest the opposite. The aim of this study was to perform a retrospective analysis to evaluate the application of radiotherapy in Dutch ACC patients, and to determine the occurrence of response.Materials and methods The Dutch ACC Registry (no.=159) was screened for patients who had received radiotherapy between 1990 and 2008. Tumor response evaluation was performed according to the Response Evaluation Criteria In Solid Tumors (RECIST).Results Only 13 patients (8% of registered patients) had received radiation therapy of whom 6 were irradiated for the palliation of painful bone metastases. In all patients this radiation resulted in pain relief. Three patients received adjuvant tumor bed radiation after resection. Four patients were radiated on irresectable tumor recurrence or tumor metastases. Two patients died soon after radiation therapy and therefore follow-up information regarding tumor response after radiation therapy of 2 patients was available. Interestingly, partial tumor response according to RECIST criteria, was observed in both patients.Conclusion ACC can be sensitive to radiotherapy and should be considered in the treatment of advanced ACC, particularly in worrisome lesions. The role of radiotherapy in advanced ACC is to complement a systemic treatment such as mitotane or classic cytotoxic agents.

Integrity signals

Registry

Crossref · 10.1007/bf03346675

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Radiotherapy has been shown in several recent series to offer a significant improvement in disease control in both adjuvant and palliative settings, although such improvement has not been universally demonstrated.

    “Although traditionally considered ineffective for ACC (327–331), radiotherapy has been shown in several recent series to offer a significant improvement in disease control in both the adjuvant and palliative settings (247, 332–337), although such an improvement has not been universally demonstrated (338).”

    From Adrenocortical carcinoma (2014) · cites this paper as [333]

  • Hermsen et al found all 6 patients treated for bone metastases were successfully palliated.

    “Hermsen et al (333) found similar outcomes, as all 6 patients that they treated for bone metastases were successfully palliated.”

    From Adrenocortical carcinoma (2014) · cites this paper as [333]

Cites

Flagged first, then by citations

1 of the 21 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Hermsen, I. G. C., Groenen, Y. E., Dercksen, M. W., Theuws, J., & Haak, H. R.
Affiliations
  • Máxima Medisch Centrum (NL)
  • Catharina Ziekenhuis (NL)
Corresponding author
Hermsen, I. G. C.
ORCID
Venue
Journal of Endocrinological Investigation
Publisher
Springer Science and Business Media LLC
Published
2010-03-10
Volume
33
Issue
10
Pages
712-714
ISSN
  • 0391-4097 (ISSN-L)
  • 1720-8386
DOI
10.1007/bf03346675
OpenAlex
W1963564387
Cited by
42
References
21
Citations by year
2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 1 · 2012: 4
FWCI
3.37
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Endocrinological Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
adrenocortical carcinoma, radiotherapy, tumor response, RECIST, palliative radiotherapy, bone metastasis, adjuvant radiotherapy, tumor recurrence, advanced disease, mitotane
MeSH terms
Adrenal Cortex Neoplasms, Aged, Bone Neoplasms, Female, Humans, Male, Middle Aged, Netherlands, Radiography, Abdominal, Recurrence, Registries, Retrospective Studies, Survival Analysis, Treatment Outcome, Adrenocortical Carcinoma, Radiotherapy, Adjuvant

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review