Glucose and free fatty acid turnover in Cushing’s syndrome
Abstract
Glucocorticoids are known to have acute effects on glucose and free fatty acid (FFA) metabolism. The effects of the longstanding hypercorticism of Cushing's syndrome were studied by isotopic techniques in a group of Cushingoid patients compared to a control group. In the Cushing's group, glucose production and utilization rates were significantly higher than in control subjects, while FFA turnover also tended to be higher, but not significantly. It is suggested that increased glucose production is the main cause of the hyperglycemia seen in Cushing's syndrome.
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Chronic GC excess does not necessarily increase whole-body lipolysis.
“The high GC phase only partially antagonized the insulin‐mediated suppression of lipolysis; thus, cortisol‐induced hyperinsulinaemia may offset this effect, which may explain why chronic GC excess does not necessarily increase whole‐body lipolysis.32, 33”
From Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct (2017) · cites this paper as [32]
Cites
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“effect, which may explain why chronic GC excess does not necessarily increase whole-body lipolysis.(32,33) It is of note that only supraphysiological cortisol concentrations”
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Self-citation
- Authors
- Saunders, J., Hall, S. E. H., & Sönksen, P. H.
- Affiliations
- St Thomas' Hospital (GB)
- ORCID
- Sönksen, P. H.
- Venue
- Journal of Endocrinological Investigation
- Published
- 1980-07
- Volume
- 3
- Issue
- 3
- Pages
- 309-311
- ISSN
- 0391-4097 (ISSN-L)
- 1720-8386
- OpenAlex
- W2096744268
- Cited by
- 14
- References
- 8
- Citations by year
- 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Endocrinological Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- Cushing's syndrome, glucose turnover, free fatty acid turnover, glucocorticoids, hypercortisolism, glucose production, glucose utilization, hyperglycemia
- MeSH terms
- Adult, Blood Glucose, Body Weight, Cushing Syndrome, Fatty Acids, Nonesterified, Female, Humans, Male, Middle Aged
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