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Cited by 38Lipid metabolism and biosynthesisAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Preferential Stimulation of Abdominal Subcutaneous Lipolysis after Prednisolone Exposure in Humans

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Gravholt, Claus Højbjerg, Dall, Rolf, Christiansen, Jens Sandahl, Møller, Niels, Schmitz, Ole·2002·Obesity Research
DOI 10.1038/oby.2002.105
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Abstract

Objective: The role of cortisol in the regulation of lipolysis is not clear. This study was undertaken to explore whether a standard dose of prednisolone for 1 week would influence lipolysis in abdominal and femoral tissue. Research Methods and Procedures: We used the microdialysis technique, the forearm technique, and indirect calorimetry, in the fasting state, after 1 week of treatment with prednisolone (30 mg daily) or placebo. Eight healthy young men (age: 25 ± 3 years; height: 181 ± 1 cm; body mass index [BMI]: 23.3 ± 0.7 kg/m 2) were studied. Results: Treatment with prednisolone induced insulin resistance (Homeostasis Model Assessment index: placebo vs. prednisolone: 7.15 ± 1.63 vs. 17.00 ± 14.26, p = 0.03), hyperinsulinemia (p = 0.01), and hyperglucagonemia (p = 0.001), whereas growth hormone concentrations were unaffected. Abdominal adipose tissue interstitial glycerol was increased during treatment with prednisolone in the face of significant hyperinsulinemia, although it barely reached statistical significance (p = 0.06). At the femoral adipose tissue depot, no difference in lipolysis was found. Arterial and venous free fatty acids (FFA) were comparable in the two situations, whereas the arteriovenous difference across the forearm was significantly decreased during treatment with prednisolone, indicating increased uptake, or decreased release of FFA. Energy expenditure (p = 0.3), repiratory quotient (p = 0.9), glucose oxidation (p = 0.9), lipid oxidation (p = 1.0), and protein oxidation (p = 0.1) were unaltered on the 2 study days. Discussion: Short‐term treatment with a standard dose of corticosteroids induces increased abdominal adipose tissue lipolysis, as well as hyperinsulinemia, hyperglucagonemia, and insulin resistance.

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  • 30 mg prednisolone daily stimulated adipose tissue, but not whole-body, lipolysis, and induced dyslipidaemia.

    “Furthermore, 30 mg prednisolone daily stimulated adipose tissue, but not whole-body, lipolysis [10], and induced dyslipidaemia [11].”

    From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [10]

    The Discussion reports increased abdominal lipolysis but unchanged femoral lipolysis, with no evidence of increased systemic lipolysis. The citing sentence omits that depot-specific limitation and states stimulation more firmly than the borderline abdominal result (p = 0.06) warrants. Dyslipidaemia is attributed to citation [11], not this paper. (LLM, conf=0.84)

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1 of the 54 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Samra JS, Clark ML, Humphreys SM, MacDonald IA, Bannister PA, Frayn KN. Effects of physiological hypercor- tisolemia on the regulation of lipolysis in subcutaneous adi- pose tissue. J Clin Endocrinol Metab. 1998;83:626 -31.

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Authors
Gravholt, C. H., Dall, R., Christiansen, J. S., Møller, N., & Schmitz, O.
Affiliations
Aarhus University Hospital (DK)
Corresponding author
Gravholt, Claus Højbjerg
ORCID
Venue
Obesity Research
Publisher
Wiley
Published
2002-08
Volume
10
Issue
8
Pages
774-781
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1038/oby.2002.105
OpenAlex
W2075210919
Cited by
38
References
54
Citations by year
2024: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 5
FWCI
0.32
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3689 d)
Locations
  • Obesity Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Aarhus Universitetshospital
  • Novo Nordisk
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
prednisolone, corticosteroids, lipolysis, abdominal fat, insulin resistance, hyperinsulinemia, hyperglucagonemia, glycerol, free fatty acids, energy expenditure, substrate oxidation, cortisol
MeSH terms
Abdomen, Adipose Tissue, Adult, Blood Glucose, C-Peptide, Calorimetry, Indirect, Double-Blind Method, Energy Metabolism, Fasting, Fatty Acids, Nonesterified, Femur, Glucagon, Glycerol, Humans, Insulin, Insulin Resistance, Lipolysis, Male, Placebos, Prednisolone, Microdialysis, Cross-Over Studies, Human Growth Hormone

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