Depressed Plasma FFA Turnover Rate in Cushing’s Syndrome
Abstract
The turnover rate of plasma FFA measured by constant infusion of albumin-complexed labeled palmitate in a group of 16 patients with Cushing's syndrome was significantly lower than in a group of 6 controls. Seven patients reexamined after correction of the hypercortisolism showed a normalization of the plasma FFA turnover rate. By contrast, 7 patients with simple obesity had a normal or increased plasma FFA turnover rate depending on the way this parameter is expressed.
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Chronic GC excess does not necessarily increase whole-body lipolysis.
“The high GC phase only partially antagonized the insulin‐mediated suppression of lipolysis; thus, cortisol‐induced hyperinsulinaemia may offset this effect, which may explain why chronic GC excess does not necessarily increase whole‐body lipolysis.32, 33”
From Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct (2017) · cites this paper as [33]
In studies addressing the effects of chronic GC treatment, typically no changes were observed in whole-body lipolysis in the fasted state, and fasting insulin levels were increased.
“In studies addressing the effects of chronic GC treatment, typically no changes were observed in whole-body lipolysis in the fasted state [32], and fasting insulin levels were increased [33, 34].”
From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [33]
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“In studies addressing the effects of chronic GC treatment, typically no changes were observed in whole-body lipolysis in the fasted state [32], and fasting insulin levels were increased [33, 34].”
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“effect, which may explain why chronic GC excess does not necessarily increase whole-body lipolysis.(32,33) It is of note that only supraphysiological cortisol concentrations”
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- Authors
- BIRKENHÄGER, J. C., TIMMERMANS, H. A. T., & LAMBERTS, S. W. J.
- Affiliations
- Academisch Ziekenhuis Rotterdam (NL)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1976-01
- Volume
- 42
- Issue
- 1
- Pages
- 28-32
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1966401867
- Cited by
- 14
- References
- 8
- Citations by year
- 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- Cushing's syndrome, free fatty acids, hypercortisolism, obesity, hypertriglyceridemia
- MeSH terms
- Adult, Body Weight, Cushing Syndrome, Fasting, Fatty Acids, Nonesterified, Female, Humans, Hydrocortisone, Male, Middle Aged, Obesity
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