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Interleukin-10 Deficiency Increases Atherosclerosis, Thrombosis, and Low-density Lipoproteins in Apolipoprotein E Knockout Mice
Open accessAbstract
Interleukin (IL)-10 is an anti-inflammatory cytokine that may play a protective role in atherosclerosis. The aim of this study was to assess the effect of IL-10 deficiency in the apolipoprotein E knockout mouse. Apolipoprotein E deficient (E-/-) and IL-10 deficient (-/-) mice were crossed to generate E-/- x IL-10-/- double knockout mice. By 16 wk, cholesterol and triglycerides were similar in double and single knockouts but the lack of IL-10 led to increased low-density lipoprotein cholesterol whereas very-low-density lipoprotein was reduced. In parallel, T-helper 1 responses and lesion size were dramatically increased in double knockout compared with E-/- controls. At 48 wk, matrix metalloproteinases and tissue factor activities were increased in lesions of double-knockout mice. Furthermore, markers of systemic coagulation were increased, and vascular thrombosis in response to i.v. thrombin occurred more frequently in E-/- x IL-10-/- than in E-/- mice. Our findings suggest that IL-10 deficiency plays a deleterious role in atherosclerosis. The early phase of lesion development was increased, and the proteolytic and procoagulant activity was elevated in advanced lesions. These data show that IL-10 may reduce atherogenesis and improve the stability of plaques.
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Metadata
- Authors
- Caligiuri, G., Rudling, M., Ollivier, V., Jacob, M.-P., Michel, J.-B., Hansson, G. K., & Nicoletti, A.
- Venue
- Molecular Medicine
- Published
- 2003-01
- Volume
- 9
- Issue
- 1-2
- Pages
- 10-17
- ISSN
- 1076-1551 (ISSN-L)
- 1528-3658
- OpenAlex
- W239859119
- Cited by
- 332
- References
- 0
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- gold
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