Cited by 1,120Atherosclerosis and Cardiovascular DiseasesPhagocytosis and Immune RegulationCholesterol and Lipid Metabolism

Macrophage death and defective inflammation resolution in atherosclerosis

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Tabas, Ira·2010·Nature Reviews Immunology

Abstract

A key event in atherosclerosis is a maladaptive inflammatory response to subendothelial lipoproteins. A crucial aspect of this response is a failure to resolve inflammation, which normally involves the suppression of inflammatory cell influx, effective clearance of apoptotic cells and promotion of inflammatory cell egress. Defects in these processes promote the progression of atherosclerotic lesions into dangerous plaques, which can trigger atherothrombotic vascular disease, the leading cause of death in industrialized societies. In this Review I provide an overview of these concepts, with a focus on macrophage death and defective apoptotic cell clearance, and discuss new therapeutic strategies designed to boost inflammation resolution in atherosclerosis.

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Crossref · 10.1038/nri2675

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  • Many chronic inflammatory diseases, including advanced atherosclerosis, are characterized by an imbalance between pro-resolving and pro-inflammatory mediators such as leukotrienes, leading to defective resolution, tissue injury, and DAMP-mediated inflammation.

    “Many chronic inflammatory diseases, including advanced atherosclerosis, are characterized by an imbalance between pro-resolving and pro-inflammatory mediators, such as leukotrienes, leading to defective resolution of inflammation, tissue injury and damage-associated molecular pattern (DAMP)-mediated inflammation31–33.”
  • Subendothelial retention of lipoproteins and immune cells in the vessel wall comprises the first stage of atherosclerosis.

    “Subendothelial retention of lipoproteins and immune cells in the vessel wall comprises the first stage of atherosclerosis.”

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Authors
Tabas, I.
Affiliations
Columbia University Irving Medical Center (US)
Corresponding author
Tabas, Ira
Venue
Nature Reviews Immunology
Published
2009-12-04
Volume
10
Issue
1
Pages
36-46
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W1964064254
Cited by
1,120
References
154
Citations by year
2026: 37 · 2025: 38 · 2024: 50 · 2023: 47 · 2022: 59 · 2021: 70 · 2020: 71 · 2019: 84 · 2018: 68 · 2017: 79 · 2016: 78 · 2015: 83 · 2014: 85 · 2013: 80 · 2012: 88
FWCI
4.97
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (HL-75662, P01HL054591, R01HL075662, HL 54591)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
atherosclerosis, inflammation resolution, macrophage cell death, efferocytosis, anti-inflammatory therapy, plaque progression
MeSH terms
Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Phagocytosis, Apoptosis, Atherosclerosis

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