Cited by 127MicroRNA in disease regulationAtherosclerosis and Cardiovascular DiseasesCytokine Signaling Pathways and Interactions

miR-155 Regulated Inflammation Response by the SOCS1-STAT3-PDCD4 Axis in Atherogenesis

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Ye, Jinshan, Guo, Ruiwei, Shi, Yankun, Qi, Feng, Guo, Chuanming, Yang, Lixia·2016·Mediators of Inflammation

Abstract

Inflammation response plays a critical role in all phases of atherosclerosis (AS). Increased evidence has demonstrated that miR-155 mediates inflammatory mediators in macrophages to promote plaque formation and rupture. However, the precise mechanism of miR-155 remains unclear in AS. Here, we also found that miR-155 and PDCD4 were elevated in the aortic tissue of atherosclerotic mice and ox-LDL treated RAW264.7 cells. Further studies showed that miR-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT and PDCD4, as well as the production of proinflammation mediators IL-6 and TNF-α. Downregulation of miR-155 and PDCD4 and upregulation of SOCS1 obviously decreased the IL-6 and TNF-α expression. In addition, inhibition of miR-155 levels in atherosclerotic mice could notably reduce the IL-6 and TNF-α level in plasma and aortic tissue, accompanied with increased p-STAT3 and PDCD4 and decreased SOCS1. Thus, miR-155 might mediate the inflammation in AS via the SOCS1-STAT3-PDCD4 axis. These results provide a rationale for intervention of intracellular miR-155 as possible antiatherosclerotic targets.

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Authors
Ye, J., Guo, R., Shi, Y., Qi, F., Guo, C., & Yang, L.
Affiliations
  • Army Medical University (CN)
  • Kunming General Hospital of Chengdu Military Command (CN)
  • Department of Cardiology, Kunming General Hospital of Chengdu Military Area, Yunnan 650032, China
Corresponding author
Yang, Lixia
Venue
Mediators of Inflammation
Publisher
Wiley
Published
2016
Volume
2016
Pages
1-14
ISSN
  • 0962-9351 (ISSN-L)
  • 1466-1861
OpenAlex
W2533066341
Cited by
127
References
49
Citations by year
2026: 11 · 2025: 11 · 2024: 14 · 2023: 19 · 2022: 11 · 2021: 9 · 2020: 21 · 2019: 18 · 2018: 8 · 2017: 5
FWCI
4.31
Type
journal article
Language
en
Open access
Locations
  • Mediators of Inflammation (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
miR-155, atherosclerosis, atherogenesis, inflammation, SOCS1, STAT3, PDCD4, macrophages, interleukin-6, TNF-α, oxidized LDL, microRNA
MeSH terms
RAW 264.7 Cells, Suppressor of Cytokine Signaling 1 Protein, Animals, Aorta, Apolipoproteins E, Inflammation, Male, Tumor Necrosis Factor-alpha, Signal Transduction, RNA-Binding Proteins, RNA, Small Interfering, MicroRNAs, Atherosclerosis, STAT3 Transcription Factor, Apoptosis Regulatory Proteins, Mice

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