The DOI matches its Crossref record; 117 of the 119 references it cites were found in a registry or an index.
Inflammatory markers and bariatric surgery: a meta-analysis
Abstract
Objective Obesity is a state of chronic low grade inflammation with increased levels of inflammatory markers such as C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF) α. The changes of some of the above markers after bariatric surgery are not consistent across studies. The objective of this study is to confirm the changes in blood levels of CRP, IL-6 and TNFα after bariatric surgery.Methods A Pubmed and EMBASE search was performed for studies measuring the above cytokines in blood before and after bariatric surgery. A meta-analysis was performed for the changes in CRP, TNFα and IL-6 for the maximum follow-up time in each study as well as for discrete follow-up times.Results Only observational studies could be retrieved. Bariatric surgery produces about 66 and 27 % reduction in CRP and IL-6 levels, respectively. The change in TNFα after bariatric surgery did not approach statistical significance.Conclusion Bariatric surgery decreases the low grade inflammation associated with obesity as measured by CRP and IL-6 levels. The change of TNFα after bariatric surgery should be further investigated with randomized trials.
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“compared with reductions of 65.8% reported in bar iatric surgery meta-analyses. 47”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [47]
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“while bar iatric surgery typically achieves reductions of 27.4 ± 3.5%. 47”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [47]
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The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
Tsalamandris, S., Antonopoulos, A. S., Oikonomou, E., Papamikroulis, G.-A., Vogiatzi, G., Papaioannou, S., Deftereos, S., & Tousoulis, D. (2019) · European Cardiology Review · doi:10.15420/ecr.2018.33.1 · Cited by 1,381
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Metadata
- Authors
- Rao, S. R.
- Affiliations
- New York University (US)
- Corresponding author
- Rao, S. Raghavendra
- ORCID
- Rao, S. Raghavendra
- Venue
- Inflammation Research
- Published
- 2012-05-16
- Volume
- 61
- Issue
- 8
- Pages
- 789-807
- ISSN
- 1023-3830 (ISSN-L)
- 1420-908X
- OpenAlex
- W2047539013
- Cited by
- 162
- References
- 119
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 5 · 2023: 14 · 2022: 13 · 2021: 13 · 2020: 13 · 2019: 12 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 21 · 2014: 17 · 2013: 8 · 2012: 2
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Inflammation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Body Contouring and Surgery
- Keywords
- bariatric surgery, obesity, low-grade inflammation, inflammatory markers, C-reactive protein, interleukin-6, TNF-α, cytokines, weight loss
- MeSH terms
- Animals, C-Reactive Protein, Humans, Inflammation, Obesity, Morbid, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Bariatric Surgery
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