Cited by 162Bariatric Surgery and OutcomesAdipokines, Inflammation, and Metabolic DiseasesBody Contouring and Surgery

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Inflammatory markers and bariatric surgery: a meta-analysis

Rao, S. Raghavendra·2012·Inflammation Research

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Abstract

Objective Obesity is a state of chronic low grade inflammation with increased levels of inflammatory markers such as C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF) α. The changes of some of the above markers after bariatric surgery are not consistent across studies. The objective of this study is to confirm the changes in blood levels of CRP, IL-6 and TNFα after bariatric surgery.Methods A Pubmed and EMBASE search was performed for studies measuring the above cytokines in blood before and after bariatric surgery. A meta-analysis was performed for the changes in CRP, TNFα and IL-6 for the maximum follow-up time in each study as well as for discrete follow-up times.Results Only observational studies could be retrieved. Bariatric surgery produces about 66 and 27 % reduction in CRP and IL-6 levels, respectively. The change in TNFα after bariatric surgery did not approach statistical significance.Conclusion Bariatric surgery decreases the low grade inflammation associated with obesity as measured by CRP and IL-6 levels. The change of TNFα after bariatric surgery should be further investigated with randomized trials.

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Authors: Rao, S. R.
Affiliations: New York University (US)
Corresponding author: Rao, S. Raghavendra
ORCID: Rao, S. Raghavendra
Venue: Inflammation Research
Publisher: Springer Science and Business Media LLC
Published: 2012-05-16
Volume: 61
Issue: 8
Pages: 789-807
ISSN: 1023-3830 (ISSN-L)
1420-908X
DOI: 10.1007/s00011-012-0473-3
OpenAlex: W2047539013
Cited by: 162
References: 119
Citations by year: 2026: 9 · 2025: 9 · 2024: 5 · 2023: 14 · 2022: 13 · 2021: 13 · 2020: 13 · 2019: 12 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 21 · 2014: 17 · 2013: 8 · 2012: 2
FWCI: 2.96
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Inflammation Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Surgery › Body Contouring and Surgery
Keywords: bariatric surgery, obesity, low-grade inflammation, inflammatory markers, C-reactive protein, interleukin-6, TNF-α, cytokines, weight loss
MeSH terms: Animals, C-Reactive Protein, Humans, Inflammation, Obesity, Morbid, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Bariatric Surgery

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Inflammatory markers and bariatric surgery: a meta-analysis

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