Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron, Lucile; Lasselin, Julie; Castanon, Nathalie

doi:10.1038/npp.2016.123

Cited by 182Tryptophan and brain disordersAdipokines, Inflammation, and Metabolic DiseasesStress Responses and Cortisol

Role of Adiposity-Driven Inflammation in Depressive Morbidity

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Capuron, Lucile, Lasselin, Julie, Castanon, Nathalie·2017·Neuropsychopharmacology

DOI 10.1038/npp.2016.123PMC PMC5143483

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Abstract

Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.

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These findings are consistent with the hypothesis that adiposity-driven inflammation may contribute to MDD-related morbidity.
“These findings are consistent with the hypothesis that adiposity-driven inflammation may contribute to MDD-related morbidity (55,56).”
From Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017) · cites this paper as [55]

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Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder
Savitz, J. B., Dantzer, R., Wurfel, B. E., Victor, T. A., Ford, B. N., Bodurka, J., Bellgowan, P. S. F., Teague, T. K., & Drevets, W. C. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.11.015 · Cited by 131 · see citing works
Chronic Low-Grade Inflammation in Metabolic Disorders: Relevance for Behavioral Symptoms
Lasselin, J., & Capuron, L. (2014) · NeuroImmunoModulation · doi:10.1159/000356535 · Cited by 129 · see citing works
Self-citation
TNFα mediates stress-induced depression by upregulating indoleamine 2,3-dioxygenase in a mouse model of unpredictable chronic mild stress
Liu, Y., Peng, Y., Liu, L., Wu, T., Zhang, Y., Lian, Y., Yang, Y., Kelley, K. W., Jiang, C., & Wang, Y. (2015) · European Cytokine Network · doi:10.1684/ecn.2015.0362 · Cited by 126 · see citing works
Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders
Ghasemi, R., Dargahi, L., Haeri, A., Moosavi, M., Mohamed, Z., & Ahmadiani, A. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8404-z · Cited by 121 · see citing works
The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats
Maric, T., Woodside, B. C., & Luheshi, G. N. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.09.011 · Cited by 117 · see citing works
Statins for the treatment of depression: A meta-analysis of randomized, double-blind, placebo-controlled trials
Salagre, E., Fernandes, B. S., Dodd, S., Brownstein, D. J., & Berk, M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.047 · Cited by 117 · see citing works
Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation
Capuron, L., Poitou, C., Machaux-Tholliez, D., Frochot, V., Bouillot, J., Basdevant, A., Layé, S., & Clément, K. (2010) · Psychological Medicine · doi:10.1017/s0033291710001984 · Cited by 115 · see citing works
Self-citation
Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression
Kariharan, T., Nanayakkara, G., Parameshwaran, K., Bagasrawala, I., Ahuja, M., Abdel‐Rahman, E. A., Amin, A. T., Dhanasekaran, M., Suppiramaniam, V. D., & Amin, R. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.028 · Cited by 115 · see citing works
A β3-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic Stress
Chuang, J.-C., Krishnan, V., Yu, H. G., Mason, B., Cui, H., Wilkinson, M. B., Zigman, J. M., Elmquist, J. K., Nestler, E. J., & Lutter, M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.003 · Cited by 114 · see citing works
Influence of depressive mood on the association of CRP and obesity in 3205 middle aged healthy men
Ladwig, K., Marten‐Mittag, B., Löwel, H., Döring, A., & Köenig, W. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00056-4 · Cited by 114 · see citing works
L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning
Chess, A. C., Landers, A., & Bucci, D. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.013 · Cited by 113 · see citing works
Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration
André, C., O’Connor, J. C., Kelley, K. W., Lestage, J., Dantzer, R., & Castanon, N. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.06.011 · Cited by 111 · see citing works
Self-citation
Chronic Immune Activation Underlies Morbid Obesity: Is IDO A Key Player?
Brandacher, G., Hoeller, E., Fuchs, D., & Weiss, H. G. (2007) · Current Drug Metabolism · doi:10.2174/138920007780362590 · Cited by 111 · see citing works
Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples
Janowitz, D., Wittfeld, K., Terock, J., Freyberger, H. J., Hegenscheid, K., Völzke, H., Habes, M., Hosten, N., Friedrich, N., Nauck, M. A., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.07.086 · Cited by 109 · see citing works
Bacille Calmette‐Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3‐Dioxygenase in Mice
Moreau, M. M., Lestage, J., Verrier, D., Mormède, C., Kelley, K. W., Dantzer, R., & Castanon, N. (2005) · The Journal of Infectious Diseases · doi:10.1086/431603 · Cited by 104 · see citing works
Self-citation
The role of adipokines in the rapid antidepressant effects of ketamine
Machado-Vieira, R., Gold, P. W., Luckenbaugh, D. A., Ballard, E. D., Richards, E. M., Henter, I. D., De Sousa, R. T., Niciu, M. J., Yuan, P., & Zarate, C. A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.36 · Cited by 102 · cited 1× · see citing works
“…have a role in the antidepressant effects of the NMDA receptor antagonist ketamine further supports the notion that inflammationinduced alterations of glutamatergic neurotransmission may contribute to the development of obesity-related depressive comorbidities (Machado-Vieira et al, 2016).”
Background
Adipose Inflammation in Obesity: Relationship With Circulating Levels of Inflammatory Markers and Association With Surgery-Induced Weight Loss
Lasselin, J., Magne, E., Beau, C., Ledaguenel, P., Dexpert, S., Aubert, A., Layé, S., & Capuron, L. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2673 · Cited by 96 · see citing works
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The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment
Gold, A. B., Herrmann, N., Swardfager, W., Black, S. E., Aviv, R. I., Tennen, G., Kiss, A., & Lanctôt, K. L. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-17 · Cited by 95 · see citing works
Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes
Kim, B., Sullivan, K. A., Backus, C., & Feldman, E. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3816 · Cited by 93 · see citing works
Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy
Xie, W., Cai, L., Yu, Y., Gao, L., Xiao, L., He, Q., Zhijun, R., & Liu, Y. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-41 · Cited by 92 · see citing works
SUCCESSFUL TREATMENT OF DEPRESSION WITH TETRAHYDROBIOPTERIN
Curtius, H. ‐., Niederwieser, A., Levine, R., Lovenberg, W. M., Woggon, B., & Angst, J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91837-8 · Cited by 91 · see citing works
Psychiatric Disorders Among Obese Patients Seeking Bariatric Surgery: Results of Structured Clinical Interviews
Duarte-Guerra, L. S., Coêlho, B. M., Santo, M. A., & Wang, Y. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1464-y · Cited by 88 · see citing works
Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation
Rummel, C., Inoue, W., Poole, S., & Luheshi, G. N. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.98 · Cited by 88 · see citing works
Antidepressant effects of insulin in streptozotocin induced diabetic mice: Modulation of brain serotonin system
Gupta, D., Kurhe, Y., & Radhakrishnan, M. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.036 · Cited by 86 · see citing works
Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes
Dias, I. C. D. S., Carabelli, B., Ishii, D. K., Morais, H., de Carvalho, M. C., de Souza, L. E. R., Zanata, S. M., Brandão, M. L., Cunha, T. M., Ferraz, A. C., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9617-0 · Cited by 86 · see citing works
Clinical Subtypes of Depression Are Associated with Specific Metabolic Parameters and Circadian Endocrine Profiles in Women: The Power Study
Cizza, G., Ronsaville, D. S., Kleitz‐Nelson, H. K., Eskandari, F., Mistry, S., Torvik, S., Sonbolian, N., Reynolds, J. C., Blackman, M. R., Gold, P. W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028912 · Cited by 85 · see citing works
Gastric Bypass Surgery is Associated with Reduced Inflammation and Less Depression: a Preliminary Investigation
Emery, C. F., Fondow, M. D. M., Schneider, C., Christofi, F. L., Hunt, C. K., Busby, A. K., NEEDLEMAN, B. J., Melvin, W. S., & Awad, H. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9140-0 · Cited by 84 · see citing works
Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome
Dinel, A., André, C., Aubert, A., Ferreira, G., Layé, S., & Castanon, N. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.014 · Cited by 84 · see citing works
Self-citation
Obesity and its associated disease: a role for microbiota?
Tehrani, A. B., Nezami, B. G., Gewirtz, A. T., & Srinivasan, S. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01895.x · Cited by 82 · see citing works
Obesity Comorbidity in Unipolar Major Depressive Disorder
Levitan, R. D., Davis, C., Kaplan, A. S., Arenovich, T., Phillips, D. I. W., & Ravindran, A. V. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m07394 · Cited by 81 · see citing works
Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice
Lawson, M. A., McCusker, R. H., & Kelley, K. W. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-54 · Cited by 80 · see citing works
Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression
Hoekstra, R., van den Broek, W. W., Fekkes, D., Bruijn, J. A., Mulder, P. G. H., & Pepplinkhuizen, L. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00282-7 · Cited by 79 · see citing works
Obesity and Its Potential Effects on Antidepressant Treatment Outcomes in Patients with Depressive Disorders: A Literature Review
Woo, Y., Seo, H.-J., McIntyre, R., & Bahk, W.-M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010080 · Cited by 79 · see citing works
The association between serum levels of neopterin and number of depressive episodes of major depression
Çelik, C., Erdem, M., Çaycı, T., Özdemir, B. H., Akgül, E. Ö., Kurt, Y. G., Yaman, H., Isıntas, M., Özgen, F., & Özşahin, A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.01.002 · Cited by 76 · see citing works
Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice
Wosiski‐Kuhn, M., Erion, J., Gómez-Sánchez, E. P., Gómez-Sánchez, C. E., & Stranahan, A. M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.020 · Cited by 76 · see citing works
Bariatric Surgery Reduces Visceral Adipose Inflammation and Improves Endothelial Function in Type 2 Diabetic Mice
Zhang, H., Wang, Y., Zhang, J., Potter, B. J., Sowers, J. R., & Zhang, C. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.225870 · Cited by 76 · see citing works

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Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies
Köhler, C. A., Freitas, T. H., Maes, M., de Andrade, N. Q., Liu, C. S., Fernandes, B. S., Stubbs, B., Solmi, M., Veronese, N., Herrmann, N., et al. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12698 · Cited by 1,443 · see citing works
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Executive Function Performance in Obesity and Overweight Individuals: A Meta-Analysis and Review
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What does plasma CRP tell us about peripheral and central inflammation in depression?
Felger, J. C., Haroon, E., Patel, T. A., Goldsmith, D. R., Wommack, E. C., Woolwine, B. J., Le, N.-A., Feinberg, R., Tansey, M. G., & Miller, A. H. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0096-3 · Cited by 448 · see citing works
Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression
Milaneschi, Y., Lamers, F., Berk, M., & Penninx, B. W. J. H. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.014 · Cited by 433 · see citing works
Peripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197 · see citing works
Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?
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Fatigue in Rheumatoid Arthritis
Katz, P. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0649-5 · Cited by 133 · see citing works
Evaluation of Adiposity and Cognitive Function in Adults
Anand, S. S., Friedrich, M. G., Lee, D. S., Awadalla, P., Després, J. P., Desai, D., de Souza, R. J., Dummer, T., Parraga, G., Larose, E., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.46324 · Cited by 125 · see citing works
Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome
de Cossío, L. F., Fourrier, C., Sauvant, J., Everard, A., Capuron, L., Cani, P. D., Layé, S., & Castanon, N. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.022 · Cited by 108 · see citing works
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Metabolomic and inflammatory signatures of symptom dimensions in major depression
Brydges, C. R., Bhattacharyya, S., Dehkordi, S. M., Milaneschi, Y., Penninx, B., Jansen, R., Kristal, B. S., Han, X., Arnold, M., Kastenmüller, G., et al. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.02.003 · Cited by 108 · see citing works
Depression and Obesity: Analysis of Common Biomarkers
Milano, W., Ambrosio, P., Carizzone, F., Biasio, V. D., Munzio, W. D., Foia, M. G., & Capasso, A. (2020) · Diseases · doi:10.3390/diseases8020023 · Cited by 107 · see citing works
Depression and peripheral inflammatory profile of patients with obesity
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Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms
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The Immunology of Behavior—Exploring the Role of the Immune System in Brain Health and Illness
Miller, A. H., Haroon, E., & Felger, J. C. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.229 · Cited by 82 · see citing works
Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis
Farzi, A., Hassan, A. M., Zenz, G., & Holzer, P. D. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.11.003 · Cited by 77 · see citing works
Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia
Bekhbat, M., Treadway, M. T., Goldsmith, D. R., Woolwine, B. J., Haroon, E., Miller, A. H., & Felger, J. C. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.015 · Cited by 77 · see citing works
Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression
Bazinet, R. P., Metherel, A. H., Chen, C. T., Shaikh, S. R., Nadjar, A., Joffre, C., & Layé, S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.001 · Cited by 80 · see citing works
Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder
Rahimian, R., Belliveau, C., Chen, R., & Mechawar, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.871997 · Cited by 73 · see citing works
Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women
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Drug-induced obesity and its metabolic consequences: a review with a focus on mechanisms and possible therapeutic options
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Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: A randomized, controlled trial
Leyrolle, Q., Cserjési, R., Mulders, M. D. G. H., Zamariola, G., Hiel, S., Gianfrancesco, M. A., Portheault, D., Amadieu, C., Bindels, L. B., Leclercq, S., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.014 · Cited by 66 · see citing works
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Glucose and lipid-related biomarkers and the antidepressant response to infliximab in patients with treatment-resistant depression
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Fatigue and sleepiness responses to experimental inflammation and exploratory analysis of the effect of baseline inflammation in healthy humans
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Depressive symptoms in obesity: Relative contribution of low-grade inflammation and metabolic health
Delgado, I., Huet, L., Dexpert, S., Beau, C., Forestier, D., Ledaguenel, P., Aubert, A., Sauvant, J., Aouizerate, B., Magne, E., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.030 · Cited by 58 · see citing works
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Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity
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Improvement in mood symptoms after post‐bariatric surgery among people with obesity: A systematic review and meta‐analysis
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Does intermittent fasting impact mental disorders? A systematic review with meta-analysis
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Drugs affecting body weight, body fat distribution, and metabolic function—mechanisms and possible therapeutic or preventive measures: an update.
Verhaegen, A. A., & Van Gaal, L. F. (2021) · Current Obesity Reports · doi:10.1007/s13679-020-00419-5 · Cited by 53 · see citing works
Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice
Demers, G., Roy, J., Machuca-Parra, A. I., Dashtehei pour, Z., Bairamian, D., Daneault, C., Rosiers, C. D., Ferreira, G., Alquier, T., Fulton, S., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0623-6 · Cited by 53 · see citing works
Statins in Depression: An Evidence-Based Overview of Mechanisms and Clinical Studies
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Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses
Shen, X., Zhao, Z., Wang, H., Guo, Z., Hu, B., & Zhang, G. (2017) · Mediators of Inflammation · doi:10.1155/2017/3709874 · Cited by 48 · see citing works
Excess body weight and specific types of depressive symptoms: Is there a mediating role of systemic low-grade inflammation?
Chu, K., Cadar, D., Iob, E., & Frank, P. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.11.016 · Cited by 45 · see citing works
Protein and gene markers of metabolic dysfunction and inflammation together associate with functional connectivity in reward and motor circuits in depression
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Inflammation as a mediator between adverse childhood experiences and adult depression: A meta-analytic structural equation model
Zagaria, A., Fiori, V., Vacca, M., Lombardo, C., Pariante, C. M., & Ballesio, A. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.04.072 · Cited by 45 · see citing works
Pre-pregnancy obesity is associated with greater systemic inflammation and increased risk of antenatal depression
Sominsky, L., O’Hely, M., Drummond, K. D., Cao, S., Collier, F., Dhar, P., Loughman, A., Dawson, S. L., Tang, M. L. K., Mansell, T., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.07.005 · Cited by 37 · see citing works
Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study
Delgado, I., Cussotto, S., Anesi, A., Dexpert, S., Aubert, A., Aouizerate, B., Beau, C., Forestier, D., Ledaguenel, P., Magne, E., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-021-01049-0 · Cited by 38 · see citing works
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Drugs That Affect Body Weight, Body Fat Distribution, and Metabolism
Verhaegen, A. A., & Gaal, L. F. V. (2019) · Europe PMC (PubMed Central) · Cited by 38 · see citing works
Brick by Brick: Building a Transdiagnostic Understanding of Inflammation in Psychiatry
Thylur, D. S., & Goldsmith, D. R. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000326 · Cited by 40 · see citing works
Biological motion during inflammation in humans
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Translational research Inflammation in depression: is adiposity a cause?
Shelton, R. C., Andrew, M., & Miller, H. (2013)

Authors: Capuron, L., Lasselin, J., & Castanon, N.
Affiliations: Université de Bordeaux (FR)
Stockholm University (SE)
Corresponding author: Capuron, Lucile
ORCID: Capuron, Lucile
Lasselin, Julie
Castanon, Nathalie
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2016-07-11
Volume: 42
Issue: 1
Pages: 115-128
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2016.123
PMC: PMC5143483
OpenAlex: W2469101786
Cited by: 182
References: 247
Citations by year: 2026: 15 · 2025: 20 · 2024: 18 · 2023: 14 · 2022: 25 · 2021: 23 · 2020: 23 · 2019: 18 · 2018: 15 · 2017: 9 · 2016: 2
FWCI: 0.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
Funders: Agence Nationale de la Recherche (ANR-13-NEUR-0004, ANR-11-JSV1-0006)
Institut National de la Recherche Agronomique
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: depression, adiposity, obesity, overweight, low-grade inflammation, neuroinflammation, brain function, therapeutic target, depression prevention
MeSH terms: Depressive Disorder, Humans, Inflammation, Overweight

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Role of Adiposity-Driven Inflammation in Depressive Morbidity

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