Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works

IL-1β Causes an Increase in Intestinal Epithelial Tight Junction Permeability

Al-Sadi, R. M., & Ma, T. Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4641 · Cited by 601 · see citing works

Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis

Su, L., Shen, L., Clayburgh, D. R., Nalle, S. C., Sullivan, E. A., Meddings, J. B., Abraham, C., & Turner, J. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.081 · Cited by 455 · see citing works

Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia

Lee, H., Kim, Y. O., Kim, H., Kim, S. Y., Noh, H. S., Kang, S. S., Cho, G. J., Choi, W. S., & Suk, K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0057fje · Cited by 278 · see citing works

Antioxidative and Anti-Inflammatory Activities of Polyhydroxyflavonoids ofScutellaria baicalensisGEORGI

Huang, W., Lee, A., & Yang, C.-H. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.50698 · Cited by 230 · see citing works

Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression

Chi, Y. S., Lim, H. A., Park, H., & Kim, H. P. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00463-5 · Cited by 212 · see citing works

Toll-like Receptor 4 Mediates Induction of the Bcl10-NFκB-Interleukin-8 Inflammatory Pathway by Carrageenan in Human Intestinal Epithelial Cells

Bhattacharyya, S., Gill, R. K., Chen, M. L., Zhang, F., Linhardt, R. J., Dudeja, P. K., & Tobacman, J. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708833200 · Cited by 170 · see citing works

Therapeutic Potential of Wogonin: A Naturally Occurring Flavonoid

Tai, M. C., Tsang, S. Y., Chang, L. Y. F., & Xue, H. (2005) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00266.x · Cited by 154 · see citing works

A Novel Mouse Model of Campylobacter jejuni Gastroenteritis Reveals Key Pro-inflammatory and Tissue Protective Roles for Toll-like Receptor Signaling during Infection

Stahl, M., Ries, J., Vermeulen, J., Yang, H. Y., Sham, H. P., Crowley, S. M., Badayeva, Y., Turvey, S. E., Gaynor, E. C., Li, X., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004264 · Cited by 117 · see citing works

The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3

Lin, Y., Huang, D.-Y., Chu, C., Lin, Y., & Lin, W. (2013) · Science Signaling · doi:10.1126/scisignal.2003973 · Cited by 91 · see citing works

Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway

Dou, W., Zhang, J., Li, H., Kortagere, S., Sun, K., Ding, L., Ren, G., Wang, Z., & Mani, S. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.04.006 · Cited by 90 · see citing works

Colorectal Cancer in Inflammatory Bowel Disease

Potack, J. Z., & Itzkowitz, S. H. (2008) · Gut and Liver · doi:10.5009/gnl.2008.2.2.61 · Cited by 88 · see citing works

Wogonin Improves Histological and Functional Outcomes, and Reduces Activation of TLR4/NF-κB Signaling after Experimental Traumatic Brain Injury

Chen, C.-C., Hung, T., Wang, Y., Lin, C., Wang, P., Lee, C.-Y., & Chen, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030294 · Cited by 83 · see citing works

Wogonin inhibits inducible prostaglandin E2 production in macrophages

Wakabayashi, I., & Yasui, K. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00695-6 · Cited by 81 · see citing works

Hypothesis about mechanisms through which nicotine might exert its effect on the interdependence of inflammation and gut barrier function in ulcerative colitis

McGilligan, V., Wallace, J. M. W., Heavey, P., Ridley, D. L., & Rowland, I. R. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20020 · Cited by 63 · see citing works

Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes

McElroy, S. J., Hobbs, S. S., Kallen, M. E., Tejera, N., Rosen, M. J., Grishin, A., Matta, P., Schneider, C. G., Upperman, J. S., Ford, H. R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038373 · Cited by 63 · see citing works

Morphine Prevents Lipopolysaccharide-Induced TNF Secretion in Mast Cells Blocking IκB Kinase Activation and SNAP-23 Phosphorylation: Correlation with the Formation of a β-Arrestin/TRAF6 Complex

Madera-Salcedo, I. K., Cruz, S. L., & González‐Espinosa, C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202658 · Cited by 63 · see citing works

Lactobacillus plantarum MYL26 induces endotoxin tolerance phenotype in Caco-2 cells

Chiu, Y., Lu, Y.-C., Ou, C., Lin, S.-L., Tsai, C.-C., Huang, C.-T., & Lin, M. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-190 · Cited by 51 · see citing works

Flavonoids exert distinct modulatory actions on cyclooxygenase 2 and NF‐κB in an intestinal epithelial cell line (IEC18)

López-Posadas, R., Ballester, I., Mascaraque, C., Suárez, M. D., Zarzuelo, A., Martínez‐Augustin, O., & de Medina, F. S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00827.x · Cited by 47 · see citing works

Increased functional expression of P-glycoprotein in Caco-2 TC7 cells exposed long-term to cadmium

Huynh-Delerme, C., Huet, H., Noël, L., Frigieri, A., & Kolf‐Clauw, M. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2004.08.003 · Cited by 46 · see citing works

Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity

Piao, H. Z., Choi, I. Y., Park, J., Kim, H.-S., Cheong, J. H., Son, K. H., Jeon, S. J., Ko, K. H., & Kim, W.-K. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.07.018 · Cited by 44 · see citing works

Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages

Huang, G.-C., Chow, J., Shen, S., Yang, L., Lin, C., & Chen, Y. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.04.001 · Cited by 37 · see citing works

LPS-binding protein enables intestinal epithelial restitution despite LPS exposure

Richter, J. M., Schanbacher, B. L., Huang, H., Xue, J., Bauer, J. A., & Giannone, P. J. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31823a895a · Cited by 36 · see citing works

Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-κB

Sina, C., Arlt, A., Gavrilova, O., Midtling, E., Kruse, M. L., Müerköster, S. S., Kumar, R., Fölsch, U. R., Schreiber, S., Rosenstiel, P. C., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21066 · Cited by 32 · see citing works

Analysis of TLR4 and TLR2 polymorphisms in inflammatory bowel disease in a Guangxi Zhuang population

Chen, L. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i46.6856 · Cited by 30 · see citing works

Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1

Wang, F., Song, X., Zhou, M., Wei, L., Dai, Q., Li, Z., Lu, N., & Guo, Q. (2012) · Toxicology · doi:10.1016/j.tox.2012.12.004 · Cited by 18 · see citing works

Analysis of TLR4 and TLR2 polymorphisms in inflammatory bowel disease in a Guangxi Zhuang population

Lan, L., Chen, Meijiao, Lin, Lingling, Zhan, Z., Xiaoping, & Lv (2012) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 16 · see citing works

Regulation of Intestinal Barrier Function by Microbial Metabolites

Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works

Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

Violi, F., Cammisotto, V., Bartimoccia, S., Pignatelli, P., Carnevale, R., & Nocella, C. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00737-2 · Cited by 384 · see citing works

The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review

Liao, H., Ye, J., Gao, L., & Liu, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110917 · Cited by 341 · see citing works

Effects of flavonoids on intestinal inflammation, barrier integrity and changes in gut microbiota during diet-induced obesity

Gil‐Cardoso, K., Ginés, I., Pinent, M., Ardèvol, A., Blay, M., & Terra, X. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000159 · Cited by 229 · see citing works

Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review

Salaritabar, A., Darvishi, B., Hadjiakhoondi, F., Manayi, A., Sureda, A., Nabavi, S. F., Fitzpatrick, L. R., Nabavi, S. M., & Bishayee, A. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i28.5097 · Cited by 200 · see citing works

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

Yu, C., Wang, D., Yang, Z., & Wang, T. Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136939 · Cited by 164 · see citing works

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Lu, P., & Zhao, Y. (2020) · Chinese Medicine · doi:10.1186/s13020-020-0296-z · Cited by 152 · see citing works

Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier

Beloqui, A., Rieux, A. D., & Véronique Préat, A. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.014 · Cited by 126 · see citing works

DHA-phospholipids (DHA-PL) and EPA-phospholipids (EPA-PL) prevent intestinal dysfunction induced by chronic stress

Cao, W., Wang, C., Chin, Y., Chen, X., Gao, Y., Yuan, S., Xue, C., Wang, Y., & Tang, Q. (2018) · Food & Function · doi:10.1039/c8fo01404c · Cited by 104 · see citing works

Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage

Zhuang, J., Peng, Y., Gu, C., Chen, H., Lin, Z., Zhou, H., Wu, X., Li, J., Yu, X., Cao, Y., et al. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00842-9 · Cited by 92 · see citing works

The role of medicinal products in the treatment of inflammatory bowel diseases ( IBD ) through inhibition of TLR4 / NF‐kappaB pathway

Dejban, P., Nikravangolsefid, N., Chamanara, M., Dehpour, A. R., & Rashidian, A. (2020) · Phytotherapy Research · doi:10.1002/ptr.6866 · Cited by 93 · see citing works

Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition

Zheng, J., Xu, H., Chunlan, H., Fan, J., Qixiang, M., Lu, Y., Lihong, L., Xingpeng, W., & Yue, Z. (2018) · Pancreatology · doi:10.1016/j.pan.2018.08.001 · Cited by 80 · see citing works

Fermented Portulaca oleracea L. Juice: A Novel Functional Beverage with Potential Ameliorating Effects on the Intestinal Inflammation and Epithelial Injury

Cagno, R. D., Filannino, P., Vincentini, O., Cantatore, V., Cavoski, I., & Gobbetti, M. (2019) · Nutrients · doi:10.3390/nu11020248 · Cited by 76 · see citing works

Rutin prevents inflammation induced by lipopolysaccharide in RAW 264.7 cells via conquering the TLR4-MyD88-TRAF6-NF-κB signalling pathway

Tian, C., Liu, X., Chang, Y., Wang, R., Yang, M., & Liu, M. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaa015 · Cited by 75 · see citing works

A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats

Gil‐Cardoso, K., Ginés, I., Pinent, M., Ardèvol, A., Terra, X., & Blay, M. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004608 · Cited by 75 · see citing works

Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties

Khan, S. M., Zhang, D., Zhang, Y., Li, M., & Wang, C. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.03.025 · Cited by 74 · see citing works

Commensal Escherichia coli Aggravates Acute Necrotizing Pancreatitis through Targeting of Intestinal Epithelial Cells

Zheng, J., Lou, L., Fan, J., Huang, C., Mei, Q., Wu, J., Guo, Y., Lu, Y., Wang, X., & Zeng, Y. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.00059-19 · Cited by 73 · see citing works

Accelerated inflammation and oxidative stress induced by LPS in acute lung injury: Ιnhibition by ST1926

Dong, Z., & Yuan, Y. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3574 · Cited by 71 · see citing works

Chronic supplementation with dietary proanthocyanidins protects from diet‐induced intestinal alterations in obese rats

Gil‐Cardoso, K., Ginés, I., Pinent, M., Ardèvol, A., Arola, L., Blay, M., & Terra, X. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201601039 · Cited by 67 · see citing works

Radioprotective Role of Peroxiredoxin 6

Sharapov, M. G., Novoselov, V. I., & Gudkov, S. V. (2019) · Antioxidants · doi:10.3390/antiox8010015 · Cited by 64 · see citing works

Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease

Li, H.-D., Chen, X., Yang, Y., Huang, H., Zhang, L., Zhang, X., Zhang, L., Huang, C., Meng, X., & Li, J. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.013 · Cited by 61 · see citing works

TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases

Totzke, J., Scarneo, S. A., Yang, K. W., & Haystead, T. (2020) · Open Biology · doi:10.1098/rsob.200099 · Cited by 60 · see citing works

Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer: A Review

Jang, J. Y., Im, E., & Kim, N. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031954 · Cited by 59 · see citing works

Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use

Kolli, U., Jalodia, R., Moidunny, S., Singh, P. K., Ban, Y. J., Tao, J., Cantu, G. N., Valdes, E., Ramakrishnan, S., & Roy, S. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2246184 · Cited by 59 · see citing works

Dietary organic acids ameliorate high stocking density stress-induced intestinal inflammation through the restoration of intestinal microbiota in broilers

Dai, D., Qi, G., Wang, J., Zhang, H., Qiu, K., Han, Y., Wu, Y., & Wu, S. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00776-2 · Cited by 54 · see citing works

Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagy in human pancreatic cancer cells

Li, S., Sun, S.-J., Gao, J., & Sun, F.-B. (2016) · Oncology Letters · doi:10.3892/ol.2016.5367 · Cited by 50 · see citing works

The role of peroxiredoxin 6 in neutralization of X-ray mediated oxidative stress: effects on gene expression, preservation of radiosensitive tissues and postradiation survival of animals

Sharapov, M. G., Novoselov, V. I., Fesenko, E. E., Брусков, В. И., & Gudkov, S. V. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1289377 · Cited by 50 · see citing works

Protective role of wogonin against cadmium induced testicular toxicity: Involvement of antioxidant, anti-inflammatory and anti-apoptotic pathways

Yu, W., Xu, Z., Gao, Q., Xu, Y., Wang, B., & Dai, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118192 · Cited by 49 · see citing works

Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells

Hui, Q., Ammeter, E., Liu, S., Yang, R., Lu, P., Lahaye, L., & Yang, C. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa245 · Cited by 48 · see citing works

Dietary Supplementation with Chlorogenic Acid Enhances Antioxidant Capacity, Which Promotes Growth, Jejunum Barrier Function, and Cecum Microbiota in Broilers under High Stocking Density Stress

Liu, Y., Zhang, Y., Bai, D., Li, Y., He, X., Ito, K., Liu, K., Tan, H., Zhen, W., Zhang, B., et al. (2023) · Animals · doi:10.3390/ani13020303 · Cited by 44 · see citing works

An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes

Chanchal, D. K., Singh, K., Bhushan, B., Chaudhary, J. S., Kumar, S., Varma, A. K., Agnihotri, N., & Garg, A. (2023) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2023.100326 · Cited by 44 · see citing works

Wogonin improves colitis by activating the AhR pathway to regulate the plasticity of ILC3/ILC1

Ye, Q., Huang, S., Wang, Y., Chen, S., Yang, H., Tan, W., Wu, Z., Wang, A., & Chen, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155425 · Cited by 43 · see citing works

Toll-Like Receptor 4 (TLR4)/Cyclooxygenase-2 (COX-2) Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion by NF-κB Activation

Wang, W., & Wang, J. (2018) · Medical Science Monitor · doi:10.12659/msm.906857 · Cited by 43 · see citing works

The role of dietary polyphenols in inflammatory bowel disease: A possible clue on the molecular mechanisms involved in the prevention of immune and inflammatory reactions

Arya, V. S., Kanthlal, S. K., & Linda, G. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13369 · Cited by 42 · see citing works

Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway

Zou, Y., Li, C., Fu, Y., JiZe, X.-P., Zhao, Y., Peng, X., Wang, J., Yin, Z., Li, Y., Song, X., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124689 · Cited by 43 · see citing works

A Comprehensive Review of Nanoparticles for Oral Delivery in Food: Biological Fate, Evaluation Models, and Gut Microbiota Influences

Xue, J., Blesso, C. N., & Luo, Y. (2022) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-060721-025159 · Cited by 41 · see citing works

Dietary soy isoflavones alleviate dextran sulfate sodium-induced inflammation and oxidative stress in mice

Wang, B., & Wu, C. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4469 · Cited by 39 · see citing works

Wogonin protects human retinal pigment epithelium cells from LPS-induced barrier dysfunction and inflammatory responses by regulating the TLR4/NF-κB signaling pathway

Chen, C., Guo, D., & Lü, G. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6252 · Cited by 38 · see citing works

MicroRNA-16 inhibits the TLR4/NF-κB pathway and maintains tight junction integrity in irritable bowel syndrome with diarrhea

Xi, M., Zhao, P., Li, F., Bao, H., Ding, S., Ji, L., & Yan, J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102461 · Cited by 37 · see citing works

Daidzein Protects Caco-2 Cells against Lipopolysaccharide-Induced Intestinal Epithelial Barrier Injury by Suppressing PI3K/AKT and P38 Pathways

Zhang, B., Wei, X., Ding, M., Luo, Z., Tan, X., & Zheng, Z. (2022) · Molecules · doi:10.3390/molecules27248928 · Cited by 36 · see citing works

Acute lung injury induced by lipopolysaccharide is inhibited by wogonin in mice via reduction of Akt phosphorylation and RhoA activation

Yeh, Y.-C., Yang, C.-P., Lee, S., Horng, C., Chen, H.-Y., Cho, T.-H., Yang, M., Lee, C., Li, M.-C., & Kuan, Y. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12500 · Cited by 36 · see citing works

Global Research Trends in Irritable Bowel Syndrome: A Bibliometric and Visualized Study

Zhang, T., Ma, X., Tian, W., Zhang, J., Wei, Y., Zhang, B., Wang, F., & Tang, X. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.922063 · Cited by 34 · see citing works

Identification of Candidate Genes Related to Inflammatory Bowel Disease Using Minimum Redundancy Maximum Relevance, Incremental Feature Selection, and the Shortest-Path Approach

Yuan, F., Zhang, Y., Kong, X., & Cai, Y. (2017) · BioMed Research International · doi:10.1155/2017/5741948 · Cited by 34 · see citing works

Immune and Metabolic Regulation Mechanism of Dangguiliuhuang Decoction against Insulin Resistance and Hepatic Steatosis

Cao, H., Tuo, L., Tuo, Y., Xia, Z., Fu, R., Liu, Y., Quan, Y., Liu, J., Yu, Z., & Xiang, M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00445 · Cited by 32 · see citing works

Effects of Huangqin Decoction on ulcerative colitis by targeting estrogen receptor alpha and ameliorating endothelial dysfunction based on system pharmacology

Li, M., Li, M., Xu, N., Li, Z.-H., Zhang, Y.-M., Gan, Y., Luo, H., Zhou, C., Liu, Y., Su, Z., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113886 · Cited by 32 · see citing works

Acai berry extract as a regulator of intestinal inflammation pathways in a Caco‐2 and RAW 264.7 co‐culture model

Kim, K. J., Kim, Y.-Y., Jin, S. G., & Kim, J. Y. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13848 · Cited by 32 · see citing works

USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4/NF-κB/ROS signaling

Jiang, Z., Shen, J., Ding, J., Yuan, Y., Gao, L., Yang, Z., & Zhao, X. (2021) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105181 · Cited by 31 · see citing works

Strain-specific regulative effects of Lactobacillus plantarum on intestinal barrier dysfunction are associated with their capsular polysaccharides

Liu, Y., Liu, Q., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.136 · Cited by 29 · see citing works

A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan

Xu, D., Hou, X., Ou, W. A. N. G., Wang, D., Li, D., Si-Yuan, Q. I. N., Lv, B., Dai, X., Zhang, Z., Wan, J., et al. (2021) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(21)60034-1 · Cited by 28 · see citing works

The Anti-Inflammatory Effect and Intestinal Barrier Protection of HU210 Differentially Depend on TLR4 Signaling in Dextran Sulfate Sodium-Induced Murine Colitis

Lin, S., Li, Y., Shen, L., Zhang, R., Yang, L., Li, M., Li, K., & Fichna, J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4404-y · Cited by 27 · see citing works

4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice

Fan, C., Wu, L., Zhang, G.-F., Xu, F., Zhang, S., Zhang, X., Sun, L., Yu, Y., Zhang, Y., & Ye, R. D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181191 · Cited by 27 · see citing works

Nutrients Bioaccessibility and Anti-inflammatory Features of Fermented Bee Pollen: A Comprehensive Investigation

Filannino, P., Cagno, R. D., Vincentini, O., Pinto, D., Polo, A., Maialetti, F., Porrelli, A., & Gobbetti, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.622091 · Cited by 28 · see citing works

Gut-resident Phascolarctobacterium succinatutens decreases fat accumulation via MYC-driven epigenetic regulation of arginine biosynthesis

Lan, Q., Sui, L.-F., Chen, B., Wang, K.-M., Chen, W., Xiao, L.-L., Liu, X.-L., Yi, L., Liu, J., Xu, X., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00792-w · Cited by 25 · see citing works

In Silico and In Vitro Anti-Helicobacter Pylori Effects of Combinations of Phytochemicals and Antibiotics

Fong, P., Hao, C.-H., Io, C.-C., Sin, P.-I., & Meng, L. (2019) · Molecules · doi:10.3390/molecules24193608 · Cited by 26 · see citing works

Wogonin upregulates SOCS3 to alleviate the injury in Diabetic Nephropathy by inhibiting TLR4-mediated JAK/STAT/AIM2 signaling pathway

Liu, Y., Zhang, M., Zeng, L., Lai, Y., Wu, S., & Su, X. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00845-4 · Cited by 25 · see citing works

Intestinal Injury in Heat Stroke

Ye, N., Yu, T., Guo, H., & Li, J. (2019) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2019.08.033 · Cited by 23 · see citing works

Cryptotanshinone and wogonin up-regulate eNOS in vascular endothelial cells via ERα and down-regulate iNOS in LPS stimulated vascular smooth muscle cells via ERβ

Barnabas, O., Chen, L., Ma, Y.-K., Yang, Y., Li, C., Geng, X., Qiu, L., Gao, X., & Wang, H. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0671-y · Cited by 23 · see citing works

More than a leaky gut: how gut priming shapes arthritis

Kuhn, K. A., Yomogida, K., Knoop, K. A., Wu, H.-J. J., & Zaiss, M. M. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01282-1 · Cited by 22 · see citing works

Wogonin suppresses the LPS‑enhanced invasiveness of MDA‑MB‑231 breast cancer cells by inhibiting the 5‑LO/BLT2 cascade

Go, J., Wei, J., Park, J., Ahn, K., & Kim, J. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3776 · Cited by 20 · see citing works

Supplementation with postbiotic from Bifidobacterium Breve BB091109 improves inflammatory status and endocrine function in healthy females: a randomized, double-blind, placebo-controlled, parallel-groups study

Motei, D. E., Beteri, B., Hepsomali, P., Tzortzis, G., Vulevic, J., & Costabile, A. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1273861 · Cited by 19 · see citing works

The Fab Fragment of a Humanized Anti-Toll Like Receptor 4 (TLR4) Monoclonal Antibody Reduces the Lipopolysaccharide Response via TLR4 in Mouse Macrophage

Cai, B., Wang, M., Zhu, X., Xu, J., Zheng, W., Zhang, Y., Zheng, F., Feng, Z., & Zhu, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025502 · Cited by 19 · see citing works

Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability

Safdari, B. K., Sia, T. C., Wattchow, D. A., & Smid, S. D. (2016) · Cytokine · doi:10.1016/j.cyto.2016.04.017 · Cited by 19 · see citing works

Hydrogen sulfide from a NaHS source attenuates dextran sulfate sodium (DSS)-induced inflammation via inhibiting nuclear factor-κB

Chen, X., & Liu, X.-S. (2016) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1500248 · Cited by 18 · see citing works

Microbial threads in the tapestry of rheumatoid arthritis

Li, J., & Kuhn, K. A. (2025) · Journal of Clinical Investigation · doi:10.1172/jci195374 · Cited by 17 · see citing works

High methionine intake alters gut microbiota and lipid profile and leads to liver steatosis in mice

Zhou, L., Yan, Z., Yang, S., Lu, G., Nie, Y., Ren, Y., Xue, Y., Shi, J., Xu, Z., & Geng, Y. (2024) · Food & Function · doi:10.1039/d4fo01613k · Cited by 18 · see citing works

Secretion of Down Syndrome Critical Region 1 Isoform 4 in Ischemic Retinal Ganglion Cells Displays Anti-Angiogenic Properties Via NFATc1-Dependent Pathway

Xu, Y., Yang, B., Hu, Y., Lü, L., Lü, X., Wang, J., Shu, Q., Cheng, Q., Yu, S., Xu, F., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0092-z · Cited by 16 · see citing works

Abdominal paracentesis drainage attenuates intestinal inflammation in rats with severe acute pancreatitis by inhibiting the HMGB1-mediated TLR4 signaling pathway

Huang, S.-Q., Wen, Y., Sun, H.-Y., Deng, J., Zhang, Y.-L., Huang, Q., Wang, B., Luo, Z., & Tang, L. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i9.815 · Cited by 16 · see citing works

Developing an Absorption–Based Quality Control Method for Hu–Gan–Kang–Yuan Capsules by UFLC–QTOF–MS/MS Screening and HPLC–DAD Quantitative Determination

Wei, F., Chen, M., Luo, C., Chen, F., Shen, Q., & Mo, Z. (2016) · Molecules · doi:10.3390/molecules21050592 · Cited by 16 · see citing works

Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC–MS/MS and application to pharmacokinetic studies

Chen, M., Wei, S., Luo, C., Chen, F., Song, S., Shen, Q., Mo, Z., & Wei, F. (2017) · Biomedical Chromatography · doi:10.1002/bmc.3966 · Cited by 15 · see citing works

CD200Fc attenuates inflammatory responses and maintains barrier function by suppressing NF-κB pathway in cigarette smoke extract induced endothelial cells

Xu, J., Lu, L., Lu, J., Xia, J., Lu, H., Yang, L., Xia, W., & Shen, S. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.09.093 · Cited by 15 · see citing works

The Effect of the Extraction Conditions on the Antioxidant Activity and Bioactive Compounds Content in Ethanolic Extracts of Scutellaria baicalensis Root

Dzięcioł, M., Wala, K., Wróblewska, A., & Janda, K. (2024) · Molecules · doi:10.3390/molecules29174153 · Cited by 14 · see citing works

TAK‐242 Ameliorates Hepatic Fibrosis by Regulating the Liver‐Gut Axis

Liu, S., Wu, J., Chen, P., Mohammed, S. A. D., Zhang, J., & Liu, S. (2022) · BioMed Research International · doi:10.1155/2022/4949148 · Cited by 14 · see citing works

Protection of tight junction between RPE cells with tissue factor targeting peptide

Zou, X., Wang, G.-F., Li, D., Chen, J.-X., Zhang, C., Yu, Y.-Z., Zhou, W., Zou, Y., & Rao, B. (2018) · International Journal of Ophthalmology · doi:10.18240/ijo.2018.10.04 · Cited by 13 · see citing works

Wogonin modulates macrophage polarization and inflammatory signaling through the LSD1-p65 axis to alleviate osteoarthritis

Cai, Z., Lu, C., Chen, D., Zhang, S., Zhou, J., Yu, S., Wong, C. K., Jia, Z., Jin, S., Feng, Y., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157149 · Cited by 12 · see citing works

The Chinese Herbal Formula Huoxiang Zhengqi Dropping Pills Prevents Acute Intestinal Injury Induced by Heatstroke by Increasing the Expression of Claudin-3 in Rats

Li, Y.-N., Tao, H., Hong, J., Xiong, Y., Pan, X., Liu, Y., Yang, X., & Zhang, H. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9230341 · Cited by 12 · see citing works

Effect of Apremilast on LPS-induced immunomodulation and inflammation via activation of Nrf2/HO-1 pathways in rat lungs

Al-Harbi, N. O., Imam, F., Al-Harbi, M. M., Qamar, W., Aljerian, K., Anwer, M. K., Alharbi, M., Almudimeegh, S., Alhamed, A. S., & Alshamrani, A. A. (2023) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2023.05.022 · Cited by 12 · see citing works

Huangqin‐Tang and Ingredients in Modulating the Pathogenesis of Ulcerative Colitis

Wang, C., Tang, X., & Zhang, L. R. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/7016468 · Cited by 12 · see citing works

Molecular Targets and Mechanisms of Scutellariae radix-Coptidis rhizoma Drug Pair for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking

Niu, K., Li, Q., Liu, Y., Qiao, Y., Li, B., Wei, C., Wang, K., Cui, L., Zheng, C., Wang, R., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/9929093 · Cited by 11 · see citing works

Dexmedetomidine alleviates intestinal barrier dysfunction and inflammatory response in mice via suppressing TLR4/MyD88/NF-κB signaling in an experimental model of ulcerative colitis

Ye, X., Xu, H., & Xu, Y. (2022) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2022.0029 · Cited by 11 · see citing works

Application of Bioactive Compounds from Scutellaria in Neurologic Disorders

Hussain, F., Mittal, S., Joshee, N., & Parajuli, P. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_5 · Cited by 9 · see citing works

Chinese herbal medicine, Tongxieyaofang, alleviates diarrhea via gut microbiota remodeling: evidence from network pharmacology and full-length 16S rRNA gene sequencing

Shao, H., Wang, L., & Zhang, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1502373 · Cited by 8 · see citing works

Naringenin attenuates Mandarin fish ranavirus (MRV)-induced hyperinflammation through the inhibition of MAPK and NF-κB signaling pathways

Zhang, Z., Ma, Y., Gao, X., Hu, C., Hao, L., Lu, H., Li, Y., & Liu, Z. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110593 · Cited by 8 · see citing works

IgG4+ plasma cell infiltration is correlated with the development of inflammatory bowel disease and can be regulated by TLR-4.

Chen, X., Sun, W., Lin, R., Huang, Z., & Chen, W. (2018) · Europe PMC (PubMed Central) · Cited by 8 · see citing works

TAK1 activates PANoptosis through the NF-κB signalling pathway to delay diabetic wound healing

Wang, X., Zhou, S., Zhang, Y., Zhang, X., Wu, S., Huang, Y., Xie, J., Xiong, K., & Yang, R. (2026) · Burns & Trauma · doi:10.1093/burnst/tkag001 · Cited by 7 · see citing works

Triclocarban exposure aggravates dextran sulfate sodium-induced colitis by deteriorating the gut barrier function and microbial community in mice

Qin, M., Lei, H., Song, Y., Wu, M., Chen, C., Cao, Z., Zhang, C., Du, R., Zhang, C., Wang, X., et al. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113908 · Cited by 7 · see citing works

Novel Fermented Ice Cream Formulations with Improved Antiradical and Anti-Inflammatory Features

Polo, A., Tlais, A. Z. A., Filannino, P., Ros, A. D., Arora, K., Cantatore, V., Vincentini, O., Nicolodi, A., Nicolodi, R., Gobbetti, M., et al. (2023) · Fermentation · doi:10.3390/fermentation9020117 · Cited by 8 · see citing works

Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis

Sumneang, N., Kobroob, A., Phungphong, S., Boonhoh, W., Punsawad, C., & Kangwan, N. (2025) · Nutrients · doi:10.3390/nu17030501 · Cited by 6 · see citing works

Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis

Lam, H. Y. P., Hung, M.-Y., Cheng, P.-C., & Peng, S.-Y. (2022) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2022.04.013 · Cited by 6 · see citing works

Flavonoids as Protective Agents Against Diet-Induced Oxidative Damage at Gastrointestinal Tract

Terra, X., Ardèvol, A., Blay, M., Pinent, M., & Salvadó, M. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805377-5.00026-6 · Cited by 6 · see citing works

The Role of Peroxiredoxins in Various Diseases Caused by Oxidative Stress and the Prospects of Using Exogenous Peroxiredoxins

Sharapov, M. G., Fesenko, E. E., & Novoselov, V. I. (2018) · BIOPHYSICS · doi:10.1134/s0006350918040164 · Cited by 6 · see citing works

Exploring the Molecular Mechanism of Tong Xie Yao Fang in Treating Ulcerative Colitis Using Network Pharmacology and Molecular Docking

Zou, M., & Zhu, Y. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/8141443 · Cited by 6 · see citing works

Non-conventional yeasts with the potential to bridge probiotic and parabiotic applications in foods and dietary supplements: genomics and human model interaction

Calabrese, F. M., Vincentini, O., Filannino, P., Battistis, F. D., Prota, V., Latronico, R., Ripari, V., Polo, M., & Angelis, M. D. (2026) · Applied Food Research · doi:10.1016/j.afres.2026.101811 · Cited by 5 · see citing works

Exploring the effect of viable but non-culturable (VBNC) state Salmonella Enteritidis on gut microbiome imbalance in an infectious colitis model

Xiao, X., Wang, W., Liu, F., Qingli, D., Maffei, D. F., Xiao, Y., Yang, H., & Yang, H. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.05.016 · Cited by 4 · see citing works

Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials

Ding, Y., Wang, C.-Y., Pan, Y.-T., Wang, Y.-J., Zhao, A., & Wen, H.-Z. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i1.114558 · Cited by 4 · see citing works

Cardiovascular protective effects of natural flavonoids on intestinal barrier injury

Zhou, P., Xu, H.-J., & Wang, L. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05213-2 · Cited by 4 · see citing works

Radioprotective Effects of Dermatan Sulfate in a Preclinical Model of Oral Mucositis—Targeting Inflammation, Hypoxia and Junction Proteins without Stimulating Proliferation

Gruber, S., Arnold, M., Çini, N., Fife, V. E. R., Hetzendorfer, S., Kowald, L.-M., Kuess, P., Mayer, J., Morava, S., Pfaffinger, S., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061684 · Cited by 4 · see citing works

Exploring the Therapeutic Potential of Natural Flavonoids in Inflammatory Bowel Disease: Insights into Intestinal Mucosal Barrier Regulation

Wang, M., Zhang, Y., Li, Y., Zhang, M., Liu, J., Cao, Y., Xie, J., & Wang, S. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266337430241127112031 · Cited by 3 · see citing works

Beneficial Effects of Proanthocyanidins on Intestinal Permeability and Its Relationship with Inflammation

González-Quilen, C., Rodríguez‐Gallego, E., Beltrán‐Debón, R., Pinent, M., Ardèvol, A., Blay, M., & Terra, X. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91212 · Cited by 3 · see citing works

Signaling Pathways and Molecular Process of Natural Polyphenols in the Amelioration of Inflammatory Bowel Disease: A Privileged Scaffold in New Drug Discovery

Prakash, O., Singh, R., Bajpai, P., & Kumari, M. (2023) · Current Drug Research Reviews · doi:10.2174/2589977515666230502153206 · Cited by 3 · see citing works

Wogonin preconditioning of MSCs improved their therapeutic efficiency for colitis through promoting glycolysis

Wu, M., Li, C., Zhou, X. M., Wu, Z., Feng, J., Guo, X., Fang, R., Lian, Q., Pan, M., Lai, X., et al. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01491-2 · Cited by 3 · see citing works

Wogonin protects human retinal pigment epithelium cells from LPS-induced barrier dysfunction and inflammatory responses by regulating the TLR4/NF-κB signaling pathway

Chen, C., Guo, D., & Lü, G. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6252 · Cited by 38 · see citing works

Wogonoside alleviates colitis by improving intestinal epithelial barrier function via the MLCK/pMLC2 pathway

Huang, S., Fu, Y., Xu, B., Liu, C., Wang, Q., Luo, S., Nong, F., Wang, X., Huang, S., Chen, J., et al. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153179 · Cited by 132 · see citing works

Wogonin Inhibits LPS-Induced Inflammatory Responses in Rat Dorsal Root Ganglion Neurons Via Inhibiting TLR4–MyD88–TAK1-Mediated NF-κB and MAPK Signaling Pathway

Chen, S. R. W., Xiong, J.-Q., Zhan, Y., Liu, W., & Wang, X. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0148-4 · Cited by 46 · see citing works

Walnut oil alleviates LPS‐induced intestinal epithelial cells injury by inhibiting TLR4/MyD88/NF‐κB pathway activation

Miao, F., Shan, C., & Ning, D. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13955 · Cited by 24 · see citing works

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

Guo, S., Al–Sadi, R., Said, H. M., & Ma, T. Y. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.10.014 · Cited by 722 · see citing works