The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Lactoferrin: Lactoferrin: a modulator of immune and inflammatory responses
Open accessAbstract
Abstract.Lactoferrin is an iron-binding glycoprotein of the transferrin family. Abundant expression and secretion of lactoferrin, in particular in milk and fluids of the digestive tract, are related to its implication in the first line of host defense. Lactoferrin is also a prominent component of the secondary granules of neutrophils (PMNs) and is released in infected tissues and blood during the inflammatory process. In addition to its direct antimicrobial properties, the abilities of lactoferrin to regulate the immune response and to protect against infection and septic shock have been described in numerous in vitro and in vivo studies. Although the cellular and molecular mechanisms that account for the modulation of the inflammatory and immune responses by lactoferrin are not yet totally elucidated, many are now established. At the cellular level, lactoferrin modulates the migration, maturation and function of immune cells. At the molecular level and in addition to iron binding, interactions of lactoferrin with a plethora of compounds, either soluble or membrane molecules, account for its modulatory properties. This paper reviews our current understanding of the cellular and molecular mechanisms that explain the regulatory properties of lactoferrin in host defence.
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Cites
LACTOFERRIN, AN IRON-BINBING PROTEIN NI NEUTROPHILIC LEUKOCYTES
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Apolactoferrin structure demonstrates ligand-induced conformational change in transferrins
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Lactoferrin is a lipid A-binding protein
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Self-citationLactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Lactoferrin a multiple bioactive protein: an overview
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Iron Homeostasis and the Inflammatory Response
Wessling-Resnick, M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104804 · Cited by 480
Lactoferrin as a natural immune modulator
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Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?
Moura, F. A., de Andrade, K. Q., dos Santos, J. C. F., Araújo, O. R. P., & Goulart, M. O. F. (2015) · Redox Biology · doi:10.1016/j.redox.2015.10.006 · Cited by 381
Metadata
- Authors
- Legrand, D., Elass, E., Carpentier, M., & Mazurier, J.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2005-11
- Volume
- 62
- Issue
- 22
- Pages
- 2549-59
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2400754861
- Cited by
- 420
- References
- 115
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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