Lactoferrin as a natural immune modulator

Actor, Jeffrey; Hwang, Shen-An; Kruzel, Marian

doi:10.2174/138161209788453202

Cited by 455Immune Response and InflammationAntimicrobial Peptides and ActivitiesInfant Nutrition and Health

Lactoferrin as a natural immune modulator

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Actor, Jeffrey, Hwang, Shen-An, Kruzel, Marian·2009·Current Pharmaceutical Design

DOI 10.2174/138161209788453202PMC PMC2915836

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Abstract

Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that bridges innate and adaptive immune function in mammals. It is a pleiotropic molecule that directly assists in the influence of presenting cells for the development of T-helper cell polarization. The aim of this review is to provide an overview of research regarding the role of lactoferrin in maintaining immune homeostasis, in particular as a mediator of immune responses to infectious assault, trauma and injury. These findings are critically relevant in the development of both prophylactic and therapeutic interventions in humans. Understanding these particular effects of lactoferrin will provide a logical framework for determining its role in health and disease.

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Lactoferrin, through binding to its cognate receptor, promotes the maturation, migration and cell proliferation of many immune cells including macrophages and monocytes, which impact the efficacy of host responses in the course of infections.
“In addition to its role in scavenging iron, lactoferrin, through binding to its cognate receptor, promotes the maturation, migration and cell proliferation of many immune cells including macrophages and monocytes which impact on the efficacy of host responses in the course of infections (Actor et al., 2009; Legrand, 2012; Lepanto et al., 2019).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Actor et al., 2009

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[157]Kruzel M Artym J Chodaczek G Kocieba M Kochanowska I Kruzel T Effects of lactoferrin on stress-related immune dysfunctions in mice and humans 4th International Whey Conference Chicago, IL 2005 121 32
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Authors: Actor, J., Hwang, S.-A., & Kruzel, M.
Affiliations: The University of Texas Health Science Center at Houston (US)
ORCID: Actor, Jeffrey
Kruzel, Marian
Venue: Current Pharmaceutical Design
Publisher: Bentham Science Publishers Ltd.
Published: 2009-06-01
Volume: 15
Issue: 17
Pages: 1956-1973
ISSN: 1381-6128 (ISSN-L)
DOI: 10.2174/138161209788453202
PMC: PMC2915836
OpenAlex: W2150336290
Cited by: 455
References: 198
Citations by year: 2026: 19 · 2025: 23 · 2024: 36 · 2023: 35 · 2022: 45 · 2021: 47 · 2020: 39 · 2019: 27 · 2018: 31 · 2017: 19 · 2016: 20 · 2015: 25 · 2014: 20 · 2013: 21 · 2012: 19
FWCI: 6.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Pharmaceutical Design (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R41GM079810)
National Institute of Allergy and Infectious Diseases (R42AI051050)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: lactoferrin, iron-binding glycoprotein, innate immunity, adaptive immunity, T helper cell polarization, immune homeostasis, infection, immunomodulation
MeSH terms: Animals, Humans, Immunity, Cellular, Immunity, Innate, Immunologic Factors, Lactoferrin, Receptors, Cell Surface, Staphylococcal Infections, Oxidative Stress, Systemic Inflammatory Response Syndrome

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Lactoferrin as a natural immune modulator

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