The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
Influence of temperature on taste perception
Open accessAbstract
Daily experience tells us that temperature has a strong influence on how we taste. Despite the longstanding interest of many specialists in this aspect of taste, we are only starting to understand the molecular mechanisms underlying the temperature dependence of different taste modalities. Recent research has led to the identification of some strong thermosensitive molecules in the taste transduction pathway. The cold activation of the epithelial Na(+) channel and the heat activation of the taste variant of the vanilloid receptor (TRPV1t) may underlie the temperature dependence of salt responses. Heat activation of the transient receptor potential channel TRPM5 explains the enhancement of sweet taste perception by warm temperatures. Current development of methods to study taste cell physiology will help to determine the contribution of other temperature-sensitive events in the taste transduction pathways. Vice versa, the analysis of the thermodynamic properties of these events may assist to unveil the nature of several taste processes.
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“the threshold for detection of sweet tastes (as well as bitter, salty and sour) shows a U-shaped response as a function of temperature, with the lowest threshold, i.e., highest sensitivity, in the 20-30 C temperature range [128-130].”
From The Role of Intrinsic and Extrinsic Sensory Factors in Sweetness Perception of Food and Beverages: A Review (2019) · cites this paper as [130]
Citations
Cites
Coding of Sweet, Bitter, and Umami Tastes
Zhang, Y., Hoon, M. A., Chandrashekar, J., Mueller, K. L., Cook, B., Wu, D., Zuker, C. S., & Ryba, N. J. P. (2003) · Cell · doi:10.1016/s0092-8674(03)00071-0 · Cited by 1,312
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
Voets, T., Droogmans, G., Wissenbach, U., Janssens, A., Flockerzi, V., & Nilius, B. (2004) · Nature · doi:10.1038/nature02732 · Cited by 1,060
Self-citationThe cells and logic for mammalian sour taste detection
Huang, A. L., Chen, X., Hoon, M. A., Chandrashekar, J., Guo, W., Tränkner, D., Ryba, N. J. P., & Zuker, C. S. (2006) · Nature · doi:10.1038/nature05084 · Cited by 840
ATP Signaling Is Crucial for Communication from Taste Buds to Gustatory Nerves
Finger, T. E., Danilova, V., Barrows, J. K., Bartel, D. L., Vigers, A. J., Stone, L. M., Hellekant, G., & Kinnamon, S. C. (2005) · Science · doi:10.1126/science.1118435 · Cited by 815
Laugerette, F. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25299 · Cited by 678
A transient receptor potential channel expressed in taste receptor cells
Pérez, C. A., Huang, L., Rong, M., Kozak, J. A., Preuss, A. K., Zhang, H., Max, M., & Margolskee, R. F. (2002) · Nature Neuroscience · doi:10.1038/nn952 · Cited by 538
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
Talavera, K., Yasumatsu, K., Voets, T., Droogmans, G., Shigemura, N., Ninomiya, Y., Margolskee, R. F., & Nilius, B. (2005) · Nature · doi:10.1038/nature04248 · Cited by 517
Self-citationTransient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor
Ishimaru, Y., Inada, H., Kubota, M., Zhuang, H., Tominaga, M., & Matsunami, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602702103 · Cited by 513
Intracellular Ca 2+ and the phospholipid PIP 2 regulate the taste transduction ion channel TRPM5
Liu, D., & Liman, E. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2334159100 · Cited by 433
TRPM5 Is a Voltage-Modulated and Ca2+-Activated Monovalent Selective Cation Channel
Hofmann, T., Chubanov, V., Gudermann, T. W., & Montell, C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00431-7 · Cited by 397
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Items 101–103 of 103
Lyu, Y., He, H., Luo, Z.-N., Zhang, T., Huang, X.-L., Peng, Z., Fu, Q., Jin, X.-B., & Xu, B. (2026) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2026.110064
Visualizing Cold: Uncovering the Sensory Visual Cues that Convey Coldness in Images
Kumari, N., Chandra, B., & Shukla, A. N. (2026) · Springer eBooks · doi:10.1007/978-981-95-6505-4_4
Botha, J. J., Diako, C., & Hort, J. (2026) · Food Quality and Preference · doi:10.1016/j.foodqual.2026.106118
Metadata
- Authors
- Talavera, K., Ninomiya, Y., Winkel, C., Voets, T., & Nilius, B.
- Affiliations
- KU Leuven (BE)
- Kyushu University (JP)
- Corresponding author
- Talavera, K.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2006-12-18
- Volume
- 64
- Issue
- 4
- Pages
- 377-381
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11149431
- OpenAlex
- W2025137341
- Cited by
- 104
- References
- 49
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 9 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 10 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 4 · 2014: 9 · 2013: 5 · 2012: 4
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Funders
- Australian Government
- Vlaamse regering
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- taste transduction, epithelial Na+ channel, TRPM5, sweetness perception, salt taste perception
- MeSH terms
- Animals, Humans, Ice Cream, Taste, Temperature, Sodium Channels, Ion Channel Gating, Transient Receptor Potential Channels, Rats
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