The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Operons
Open accessAbstract
Operons (clusters of co-regulated genes with related functions) are common features of bacterial genomes. More recently, functional gene clustering has been reported in eukaryotes, from yeasts to filamentous fungi, plants, and animals. Gene clusters can consist of paralogous genes that have most likely arisen by gene duplication. However, there are now many examples of eukaryotic gene clusters that contain functionally related but non-homologous genes and that represent functional gene organizations with operon-like features (physical clustering and co-regulation). These include gene clusters for use of different carbon and nitrogen sources in yeasts, for production of antibiotics, toxins, and virulence determinants in filamentous fungi, for production of defense compounds in plants, and for innate and adaptive immunity in animals (the major histocompatibility locus). The aim of this article is to review features of functional gene clusters in prokaryotes and eukaryotes and the significance of clustering for effective function.
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Cites
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Cited by
Molecular activities, biosynthesis and evolution of triterpenoid saponins
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Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential
Roberts, A. B., Gu, X., Buffa, J. A., Hurd, A. G., Wang, Z., Zhu, W., Gupta, N., Skye, S. M., Cody, D. B., Levison, B. S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0128-1 · Cited by 552
Two rings in them all: The labdane-related diterpenoids
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Diversification of P450 Genes During Land Plant Evolution
Mizutani, M., & Ohta, D. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112305 · Cited by 411
Metadata
- Authors
- Osbourn, A. E., & Field, B.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2009-08-07
- Volume
- 66
- Issue
- 23
- Pages
- 3755-3775
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W3189516953
- Cited by
- 214
- References
- 10
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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