Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
Abstract
The enteroendocrine system orchestrates how the body responds to the ingestion of foods, employing a diversity of hormones to fine-tune a wide range of physiological responses both within and outside the gut. Recent interest in gut hormones has surged with the realization that they modulate glucose tolerance and food intake through a variety of mechanisms, and such hormones are therefore excellent therapeutic candidates for the treatment of diabetes and obesity. Characterizing the roles and functions of different enteroendocrine cells is an essential step in understanding the physiology, pathophysiology, and therapeutics of the gut-brain-pancreas axis.
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Because bacterial fermentation of non-digested nutrients continues between meals, bacterial metabolites can support the activity of colonic L cells and the secretion of anorexigenic hormones for many hours after a meal.
“Because bacterial fermentation of non-digested nutrients continues between meals, bacterial metabolites can support the activity of colonic L cells and the secretion of anorexigenic hormones for many hours after a meal (Gribble and Reimann, 2016).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Gribble and Reimann, 2016
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Self-citation
- Authors
- Gribble, F. M., & Reimann, F.
- Affiliations
- University of Cambridge (GB)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2016-02-10
- Volume
- 78
- Issue
- 1
- Pages
- 277-299
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W1945952457
- Cited by
- 683
- References
- 20
- Citations by year
- 2026: 77 · 2025: 81 · 2024: 69 · 2023: 79 · 2022: 62 · 2021: 76 · 2020: 65 · 2019: 52 · 2018: 59 · 2017: 40 · 2016: 22 · 2015: 1
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AstraZeneca
- Wellcome Trust (106263/Z/14/Z, 106262/Z/14/Z)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- enteroendocrine cells, gastrointestinal hormones, intestinal epithelium, chemical sensors, glucose tolerance, food intake regulation, diabetes mellitus, obesity, hormone secretion
- MeSH terms
- Animals, Eating, Gastrointestinal Hormones, Humans, Intestinal Mucosa, Obesity, Enteroendocrine Cells, Gastrointestinal Tract
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