Cited by 717Gut microbiota and healthEscherichia coli research studiesGastrointestinal motility and disorders

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

Martens, Eric C., Neumann, Mareike, Desai, Mahesh S.·2018·Nature Reviews Microbiology

Abstract

The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection. In this Review, we discuss the current state of knowledge of the complex interactions of commensal microorganisms with the intestinal mucosal barrier, and we discuss strategies used by pathogenic microorganisms to establish infection by either exploiting different epithelial cell lineages or disrupting the mucous layer, as well as the role of defects in mucus production in chronic disease.

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Crossref · 10.1038/s41579-018-0036-x

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156 of 156 references verified0 citation errors · 0 not checkable

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  • Because mucin- and junction-degrading bacteria can cause damage, these enzymes may provide targets for protease inhibitors to treat or prevent intestinal diseases.

    “As mucin- and junction-degrading bacteria can cause damage, these enzymes may provide targets for protease inhibitors to treat or prevent intestinal diseases.25,117”

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Authors
Martens, E. C., Neumann, M., & Desai, M. S.
Affiliations
  • University of Michigan (US)
  • Luxembourg Institute of Health (LU)
  • University of Southern Denmark (DK)
Corresponding author
  • Martens, Eric C.
  • Desai, Mahesh S.
Venue
Nature Reviews Microbiology
Published
2018-06-14
Volume
16
Issue
8
Pages
457-470
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W2807724532
Cited by
711
References
156
Citations by year
2026: 62 · 2025: 93 · 2024: 106 · 2023: 104 · 2022: 149 · 2021: 96 · 2020: 54 · 2019: 41 · 2018: 6
FWCI
4.82
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders
  • Kenneth Rainin Foundation
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
intestinal barrier, commensal microorganisms, enteric pathogens, mucus layer, intestinal epithelial cells, host defense, chronic intestinal diseases
MeSH terms
Bacteria, Humans, Intestinal Mucosa, Symbiosis, Bacterial Physiological Phenomena

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