Novel siRNA delivery strategy: a new "strand" in CNS translational medicine?

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CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells

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Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

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Mitochondrial dysfunction in Parkinson's disease

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Lipid-based Nanoparticles for Nucleic Acid Delivery

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Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents

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Molecular Mechanisms of Glioma Cell Migration and Invasion

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Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

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Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

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Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

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Sequence, Chemical, and Structural Variation of Small Interfering RNAs and Short Hairpin RNAs and the Effect on Mammalian Gene Silencing

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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS

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Identification and Design of Peptides as a New Drug Delivery System for the Brain

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Lipid‐based nanotherapeutics for siRNA delivery

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Safety and tolerability of putaminal <i>AADC</i> gene therapy for Parkinson disease

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Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood–Brain Barrier Damage in Early Ischemic Stroke Stage

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Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

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Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA

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Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model

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Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA

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siRNA relieves chronic neuropathic pain

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Results from a phase I safety trial of <i>hAADC</i> gene therapy for Parkinson disease

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Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

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SiRNA delivery with exosome nanoparticles.

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Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

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RNAi and small interfering RNAs in human disease therapeutic applications

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Neurovascular Protection Reduces Early Brain Injury After Subarachnoid Hemorrhage

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Angiogenesis and invasion in glioma

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Five siRNAs Targeting Three SNPs May Provide Therapy for Three-Quarters of Huntington's Disease Patients

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Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease

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Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing

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Polymeric nanoparticles for the drug delivery to the central nervous system

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Nanotechnology approach for drug addiction therapy: Gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons

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Body distribution of fully biodegradable [14C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats

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Ubiquitylation of synphilin-1 and α-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

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The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity

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Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System

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shRNA and siRNA delivery to the brain

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The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

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α-Synuclein fate is determined by USP9X-regulated monoubiquitination

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Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis

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Minocycline-Preconditioned Neural Stem Cells Enhance Neuroprotection after Ischemic Stroke in Rats

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TRPV1 Activation Is Required for Hypertonicity-Stimulated Inflammatory Cytokine Release in Human Corneal Epithelial Cells

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Eight Years of Clinical Improvement in MPTP-Lesioned Primates After Gene Therapy With AAV2-hAADC

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Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction

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Lipidic Systems for In Vivo siRNA Delivery

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Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

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Notch Signaling Pathway and Cancer Metastasis

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In Vivo Specific Delivery of c-Met siRNA to Glioblastoma Using Cationic Solid Lipid Nanoparticles

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Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease

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Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders

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Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain

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Inhibition of Oxygen-Induced Retinopathy in RTP801-Deficient Mice

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Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration

Sundaram, J. R., Chan, E. S., Poore, C. P., Pareek, T. K., Cheong, W. F., Shui, G., Tang, N., Low, C., Wenk, M. R., & Kesavapany, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5177-11.2012 · Cited by 127 · see citing works

Induction of Autophagy by Cystatin C: A Mechanism That Protects Murine Primary Cortical Neurons and Neuronal Cell Lines

Tizón, B., Sahoo, S., Yu, W. H., Gauthier, S. A., Kumar, A. R., Mohan, P. S., Figliola, M. J., Pawlik, M., GRUBB, A. O., Uchiyama, Y., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009819 · Cited by 125 · see citing works

A majority of Huntington's disease patients may be treatable by individualized allele-specific RNA interference

Lombardi, M. S., Jaspers, L., Spronkmans, C., Gellera, C., Taroni, F., Maria, E. D., Donato, S. D., & Kaemmerer, W. F. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.004 · Cited by 124 · see citing works

Small interfering RNA-mediated selective knockdown of NaV1.8 tetrodotoxin-resistant sodium channel reverses mechanical allodynia in neuropathic rats

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NFκB inhibitors induce cell death in glioblastomas

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Siah-1 Facilitates Ubiquitination and Degradation of Synphilin-1

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Allele-Selective Inhibition of Huntingtin Expression by Switching to an miRNA-like RNAi Mechanism

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Angiopoietin 2 Mediates the Differentiation and Migration of Neural Progenitor Cells in the Subventricular Zone after Stroke

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Protein Kinase Cδ Negatively Regulates Tyrosine Hydroxylase Activity and Dopamine Synthesis by Enhancing Protein Phosphatase-2A Activity in Dopaminergic Neurons

Zhang, D., Kanthasamy, A., Yang, Y., Anantharam, V., & Kanthasamy, A. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4107-06.2007 · Cited by 103 · see citing works

Immune responses against adenoviral vectors and their transgene products: a review of strategies for evasion

Schagen, F. H. E., Ossevoort, M., Toes, R. E. M., & Hoeben, R. C. (2003) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(03)00172-0 · Cited by 102 · see citing works

Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse

Xin, H., Li, Y., Shen, L. H., Liu, X., Wang, X., Zhang, J., Pourabdollah-Nejad D, S., Zhang, C., Zhang, L., Jiang, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009027 · Cited by 101 · see citing works

Pluronic-coated carbon nanotubes do not induce degeneration of cortical neurons in vivo and in vitro

Bardi, G., Tognini, P., Ciofani, G., Raffa, V., Costa, M., & Pizzorusso, T. (2008) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2008.06.008 · Cited by 100 · see citing works

The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke

Wang, L., Chopp, M., Zhang, R. L., Zhang, L., LeTourneau, Y., Feng, Y. F., Jiang, A., Morris, D. C., & Zhang, Z. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.064 · Cited by 100 · see citing works

Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3

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Gene therapy in Alzheimer’s disease – potential for disease modification

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