Neuropeptide substance P and the immune response

Substance P antagonist improves both obesity and asthma in a mouse model

Ramalho, R., Almeida, J., Beltrão, M., Pirraco, A., Costa, R., Sokhatska, O., Guardão, L., Palmares, C., Guimarães, J. T., Delgado, L., et al. (2012) · Allergy · doi:10.1111/all.12052 · Cited by 40

Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers

Tebas, P., Spitsin, S. V., Barrett, J. S., Tuluc, F., Elci, O. U., Korelitz, J., Wagner, W., Winters, A., Kim, D., Catalano, R., et al. (2015) · AIDS · doi:10.1097/qad.0000000000000638 · Cited by 40

Developmental Corneal Innervation: Interactions between Nerves and Specialized Apical Corneal Epithelial Cells

Kubilus, J. K., & Linsenmayer, T. F. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3942 · Cited by 40

Substance P Promotes Susceptibility toPseudomonas aeruginosaKeratitis in Resistant Mice: Anti-inflammatory Mediators Downregulated

McClellan, S. A., Zhang, Y., Barrett, R. P., et al. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1369 · Cited by 39

Localization of neuropeptides in the cornea and uvea of the rat: an immunohistochemical study.

Shimizu, Y. (1982) · PubMed · Cited by 39

Substance P receptor mediated maintenance of chronic inflammation in EAE

Reinke, E. K., Johnson, M. J., Ling, C., et al. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.07.010 · Cited by 38

Airway Smooth Muscle Cells Express Functional Neurokinin-1 Receptors and the Nerve-Derived Preprotachykinin-A Gene

Maghni, K., Michoud, M.-C., Alles, M., et al. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4635 · Cited by 37

Substance P immunoreactive nerves in the rodent cornea

Tervo, K., Tervo, T., Eränkö, L., & Eränkö, O. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90107-5 · Cited by 37

Tachykinin NK1 receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation

Tumati, S., Largent‐Milnes, T. M., Keresztes, A. I., Yamamoto, T., Vanderah, T. W., Roeske, W. R., Hruby, V. J., & Varga, E. V. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.03.025 · Cited by 37

Retinal Laser Burn-Induced Neuropathy Leads to Substance P-Dependent Loss of Ocular Immune Privilege

Lucas, K. G., Karamichos, D., Mathew, R., Zieske, J. D., & Stein‐Streilein, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103264 · Cited by 37

Th17 polarization of memory Th cells in early arthritis: the vasoactive intestinal peptide effect

Jimeno, R., Leceta, J., Garin, M. I., Ortiz, A. M., Mellado, M., Rodrı́guez-Frade, J. M., Martínez, C., Pérez‐García, S., Gomariz, R. P., & Juarranz, Y. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0714-327r · Cited by 37

Neuropeptide SP activates the WNT signal transduction pathway and enhances the proliferation of bone marrow stromal stem cells

Mei, G., Xia, L., Zhou, J., et al. (2013) · Cell Biology International · doi:10.1002/cbin.10158 · Cited by 36

Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis

Vilisaar, J., Kawabe, K., Braitch, M. K., et al. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9589-x · Cited by 36

HIV infection of macrophages is enhanced in the presence of increased expression of CD163 induced by substance P

Tuluc, F., Meshki, J., Spitsin, S. V., & Douglas, S. D. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.4ab0813-434rr · Cited by 35

Ocular surgical models for immune and angiogenic responses

Inomata, T., Mashaghi, A., Zazzo, A. D., & Dana, R. (2015) · Journal of Biological Methods · doi:10.14440/jbm.2015.78 · Cited by 35

Demonstration of a substance P-like immunoreactivity in retinal cells of the rat

Fukuda, M., Kuwayama, Y., Shiosaka, S., et al. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90004-5 · Cited by 35

Phosphorylation and Desensitization of the Neurokinin‐1 Receptor Expressed in Epithelial Cells

Vigna, S. R. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.01925.x · Cited by 35

Endothelin‐converting enzyme‐1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones

Pelayo, J., Poole, D. P., Steinhoff, M. S., Cottrell, G. S., & Bunnett, N. W. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.214452 · Cited by 34

Stimulation of CCL2 (MCP-1) and CCL2 mRNA by substance P in LAD2 human mast cells

Castellani, M. L., Vecchiet, J., Salini, V., Conti, P., Theoharides, T. C., Caraffa, A., Antinolfi, P., Tetè, S., Ciampoli, C., Cuccurullo, C., et al. (2009) · Translational research · doi:10.1016/j.trsl.2009.03.006 · Cited by 33

Treatment with Neurokinin-1 Receptor Antagonist Reduces Severity of Inflammatory Bowel Disease Induced byCryptosporidium parvum

Sonea, I. M., Palmer, M. V., Akili, D., et al. (2002) · Clinical and Vaccine Immunology · doi:10.1128/cdli.9.2.333-340.2002 · Cited by 33

Substance P regulates the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in cultured human gingival fibroblasts

Cury, P. R., Canavez, F., de Araújo, V. C., et al. (2007) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2007.01022.x · Cited by 32

Substance P augments nitric oxide production and gene expression in murine macrophages

Jeon, H. K., Jung, N. P., Choi, I. H., et al. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00033-8 · Cited by 32

Substance P-immunoreactive astrocytes related to deep white matter and striatal blood vessels in human brain

Michel, J.-P., Sakamoto, N., Bouvier, R., Tommasi, M., & Pearson, J. (1986) · Brain Research · doi:10.1016/0006-8993(86)90886-3 · Cited by 31

Impact of substance P on cellular immunity.

Katsanos, G., Anogeianaki, A., Orso, C. A., et al. (2008) · PubMed · Cited by 30

Characterization of GRK2-Catalyzed Phosphorylation of the Human Substance P Receptor in Sf9 Membranes

Nishimura, K., Warabi, K., Roush, E. D., et al. (1998) · Biochemistry · doi:10.1021/bi972302s · Cited by 30

Substance-P-like immunoreactive amacrine cells in the adult and the developing rat retina

Zhang, D., & Yeh, H. H. (1992) · Developmental Brain Research · doi:10.1016/0165-3806(92)90247-t · Cited by 30

Regulation of substance P mRNA expression in human dermal microvascular endothelial cells.

Milner, P., Bodin, P., Guiducci, S., Rosso, A. D., Kahaleh, M. B., Matucci‐Cerinic, M., & Burnstock, G. (2004) · PubMed · Cited by 29

Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System

Lewis, K., Turner, R. J., & Vink, R. (2013) · International Journal of Inflammation · doi:10.1155/2013/578480 · Cited by 29

Enhanced Immunoglobulin A Response and Protection againstSalmonella entericaSerovar Typhimurium in the Absence of the Substance P Receptor

Walters, N., Trunkle, T., Sura, M. E., et al. (2004) · Infection and Immunity · doi:10.1128/iai.73.1.317-324.2005 · Cited by 29

Modulation of regulatory T cell immunity by the neuropeptide alpha-melanocyte stimulating hormone.

Taylor, A. W. (2003) · PubMed · Cited by 28

Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine schistosomiasis mansoni

Blum, A. M., Metwali, A., Crawford, C., et al. (2001) · The FASEB Journal · doi:10.1096/fj.00-0379 · Cited by 27

Vasoactive Intestinal Peptide–Mediated Th17 Differentiation

Yadav, M., & Goetzl, E. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.020 · Cited by 26

Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor

Murphy, J. E., Roosterman, D., Cottrell, G. S., Padilla, B. E., Feld, M., Brand, E., Cedron, W. J., Bunnett, N. W., & Steinhoff, M. S. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00096.2011 · Cited by 26

Neuropeptide Signaling Activates Dendritic Cell-Mediated Type 1 Immune Responses through Neurokinin-2 Receptor

Kitamura, H., Kobayashi, M., Wakita, D., & Nishimura, T. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102521 · Cited by 26

Upregulation of Tumor Necrosis Factor-Alpha by Stress and Substance P in a Murine Model of Allergic Airway Inflammation

Joachim, R., Sagach, V., Quarcoo, D., Dinh, T., Arck, P., & Klapp, B. F. (2006) · NeuroImmunoModulation · doi:10.1159/000094394 · Cited by 25

Neurokinin A engages neurokinin-1 receptor to induce NF-κB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways

Sun, J. T., Ramnath, R. D., Tamizhselvi, R., et al. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00042.2008 · Cited by 25

Stimulation of Transcriptional Regulatory Activity by Substance P

Christian, C., Gilbert, M. J., & Payan, D. G. (2006) · NeuroImmunoModulation · doi:10.1159/000097156 · Cited by 24

Substance P and multiple sclerosis

Barker, R. A., & Larner, A. J. (1992) · Medical Hypotheses · doi:10.1016/0306-9877(92)90011-z · Cited by 24

[Neurotrophic keratopathy--studies on substance P and the clinical significance of corneal sensation].

Nishida, T., Nakamura, M., Konma, T., et al. (1997) · PubMed · Cited by 24

Effect of substance P on recovery from laser‐induced retinal degeneration

Hong, H. S., Kim, S., Nam, S.-W., Um, J., Kim, Y. H., & Son, Y. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12264 · Cited by 23

Substance P Enhances Th17 Phenotype in Individuals with Generalized Anxiety Disorder: an Event Resistant to Glucocorticoid Inhibition

Barros, P. O., Ferreira, T. B., Vieira, M. M. M., Almeida, C. R. M., Araújo-Lima, C. F., Silva-Filho, R. G., Hygino, J., de Andrade, R. M., Andrade, A. F. B., & Bento, C. A. M. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9466-6 · Cited by 21

Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes

Ikeda, Y., Takei, H., Matsumoto, C., Mase, A., Yamamoto, M., Takeda, S., Ishige, A., & Watanabe, K. (2007) · Archives of Dermatological Research · doi:10.1007/s00403-007-0767-4 · Cited by 20

Separate influences of insulin and hyperglycemia on hepatic drug metabolism in mice with genetic and chemically induced diabetes mellitus.

Knodell, R. G., Handwerger, B. S., Morley, J. E., et al. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21419-7 · Cited by 19

Calcitonin gene-related peptide modulates Langerhans cell antigen-presenting function.

Asahina, A., Hosoi, J., Gf, M., et al. (1995) · PubMed · Cited by 19

Regulation of NK92‐MI Cell Cytotoxicity by Substance P

Fu, W. X., Qin, B., Zhou, A., Yu, Q., Huang, Q., & Liang, Z. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02550.x · Cited by 18

Substance P (NK1) receptor expression by human colonic epithelial cell line Caco-2

Böckmann, S. (2002) · Peptides · doi:10.1016/s0196-9781(02)00135-3 · Cited by 17

Substance P induces inositol 1,4,5‐trisphosphate and intracellular free calcium increase in cultured normal human epidermal keratinocytes

Koizumi, H., Yasui, C., Fukaya, T., et al. (1994) · Experimental Dermatology · doi:10.1111/j.1600-0625.1994.tb00264.x · Cited by 15

Endothelin-Converting Enzyme-1 (ECE-1) Is Post-Transcriptionally Regulated by Alternative Polyadenylation

Whyteside, A. R., Turner, A. J., & Lambert, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083260 · Cited by 14

Harnessing DCs by substance P

Takashima, A. (2013) · Blood · doi:10.1182/blood-2013-02-483354 · Cited by 11

IL-4, but not vitamin D3, induces monoblastic cell line UG3 to differentiate into multinucleated giant cells on osteoclast lineage

Kaji, Y., Ikeda, K., Ikeda, T., Kawakami, K., Sasaki, K., Shindo, M., Hatake, K., Harada, M., Motoyoshi, K., Mori, S., et al. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200002)182:2 · Cited by 10

Localization of substance P‐induced upregulated interleukin‐8 expression in human dental pulp explants

Huang, G. T. ‐., Lee, H. W., Lee, H. S., et al. (2007) · International Endodontic Journal · doi:10.1111/j.1365-2591.2007.01318.x · Cited by 10

Mechanisms of cell division as regulators of acute immune response

Kan, A., & Hodgkin, P. D. (2014) · Systems and Synthetic Biology · doi:10.1007/s11693-014-9149-3 · Cited by 9

Systems and synthetic biology approaches to cell division

Mashaghi, A., & Dekker, C. (2014) · Systems and Synthetic Biology · doi:10.1007/s11693-014-9132-z · Cited by 7

Rochlitzer, S. et al. The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function. Clin. Exp. Allergy 41, 1609-1621

Rochlitzer, S., Veres, T. Z., Kühne, K., et al. (2011) · Cited by 7

Substance P and IL‐33 Synergistically Stimulate Mast Cells to Release IL‐1β and TNF‐α implicated in psoriasis; inhibition by the flavonoid methoxyluteolin

Taracanova, A., & Theoharides, T. C. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.lb474 · Cited by 2

Substance P and IL-33 synergistically stimulate mast cells to release IL-1β and TNF-α implicated in psoriasis; inhibition by the flavonoid methoxyluteolin (THER2P.960)

Taracanova, A., & Theoharides, T. C. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.194.supp.67.11 · Cited by 1

[Pathomorphological characteristics of the intervertebral disks in scoliosis of varying etiology].

Mn, P., Kaz'min, A. I., Abal'masova, E. A., et al. (1976) · PubMed · Cited by 1

Untitled work

Rodriguez-Palmero, M. (1999) · doi:10.1002/(sici)1521-4141(199912)29:12

Hallmarks of peripheral nerve function in bone regeneration

Tao, R., Mi, B., Hu, Y., Lin, S., Xiong, Y., Lu, X., Panayi, A. C., Li, G., & Liu, G. (2023) · Bone Research · doi:10.1038/s41413-022-00240-x · Cited by 110

Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis

Yan, D., Liu, X., & Guo, S.-W. (2019) · Scientific Reports · doi:10.1038/s41598-019-39170-w · Cited by 82

Myalgic encephalomyelitis/chronic fatigue syndrome—metabolic disease or disturbed homeostasis due to focal inflammation in the hypothalamus?

Hatziagelaki, E., Adamaki, M., Tsilioni, I., Dimitriadis, G., & Theoharides, T. C. (2018) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.250845 · Cited by 62

Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis

Admasu, T. D., Kim, K., Rae, M. J., Avelar, R. A., Gonciarz, R. L., Rebbaa, A., de Magalhães, J. P., Renslo, A. R., Stolzing, A., & Sharma, A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112058 · Cited by 49

Peptidergic (neurotensin, VIP, substance P) nerve fibres in the skin. Immunohistochemical evidence of an involvement of neuropeptides in nociception, pruritus and inflammation

Hartschuh, W., Weihe, E., & Reinecke, M. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1983.tb06811.x · Cited by 113

Upregulation of the neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP), in primary sensory neurons following cutaneous inflammation

Leslie, T. A., Emson, P. C., Woolf, C. J., et al. (1993) · Journal of Dermatological Science · doi:10.1016/0923-1811(93)90895-v · Cited by 1

Sensory Neuropeptides Contribute to Oedema Formation in Experimental Burns

Dalsgaard, C., Jonsson, C. E., Hægerstrand, A., et al. (1987) · Scandinavian Journal of Plastic and Reconstructive Surgery · doi:10.3109/02844318709086463 · Cited by 5

Bilateral changes of substance P-, neurokinin A-, calcitonin gene-related peptide- and neuropeptide Y-like immunoreactivity in rat knee joint synovial fluid during acute monoarthritis

Bileviciute, I., Lundeberg, T., Ekblom, A., et al. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90071-r · Cited by 95