The DOI matches its Crossref record; 258 of the 258 references it cites were found in a registry or an index.
Neuropeptide substance P and the immune response
Open accessAbstract
Substance P is a peptide mainly secreted by neurons and is involved in many biological processes, including nociception and inflammation. Animal models have provided insights into the biology of this peptide and offered compelling evidence for the importance of substance P in cell-to-cell communication by either paracrine or endocrine signaling. Substance P mediates interactions between neurons and immune cells, with nerve-derived substance P modulating immune cell proliferation rates and cytokine production. Intriguingly, some immune cells have also been found to secrete substance P, which hints at an integral role of substance P in the immune response. These communications play important functional roles in immunity including mobilization, proliferation and modulation of the activity of immune cells. This review summarizes current knowledge of substance P and its receptors, as well as its physiological and pathological roles. We focus on recent developments in the immunobiology of substance P and discuss the clinical implications of its ability to modulate the immune response.
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“Functioning through NK1R, which is widely expressed in immune cells, SP has been reported to be a potent neuroimmunomodulator78.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [78]
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Yan, D., Liu, X., & Guo, S.-W. (2019) · Scientific Reports · doi:10.1038/s41598-019-39170-w · Cited by 82
Hatziagelaki, E., Adamaki, M., Tsilioni, I., Dimitriadis, G., & Theoharides, T. C. (2018) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.250845 · Cited by 62
Metadata
- Authors
- Mashaghi, A., Marmalidou, A., Tehrani, M., Grace, P. M., Pothoulakis, C., & Dana, R.
- Affiliations
- Massachusetts Eye and Ear Infirmary (US)
- University of Colorado Boulder (US)
- University of California, Los Angeles (US)
- Corresponding author
- Dana, Reza
- ORCID
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-06-17
- Volume
- 73
- Issue
- 22
- Pages
- 4249-4264
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC5056132
- OpenAlex
- W2442224165
- Cited by
- 493
- References
- 258
- Citations by year
- 2026: 61 · 2025: 56 · 2024: 53 · 2023: 73 · 2022: 64 · 2021: 65 · 2020: 53 · 2019: 29 · 2018: 20 · 2017: 16 · 2016: 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Foundation for the National Institutes of Health (R01 DK047343, EY020889, EY012963)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- substance P, neuropeptides, immune response, neuroimmune interactions, neurokinin-1 receptor, cytokine production, immune cell proliferation, inflammation, nociception, paracrine signaling, hormone signaling, immune cell mobilization
- MeSH terms
- Amino Acid Sequence, Animals, Disease, Humans, Immunity, Substance P, Signal Transduction, Immunomodulation
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