Cited by 493Neuropeptides and Animal PhysiologyPain Mechanisms and TreatmentsVagus Nerve Stimulation Research

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Neuropeptide substance P and the immune response

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Mashaghi, Alireza, Marmalidou, Anna, Tehrani, Mohsen, Grace, Peter M., Pothoulakis, Charalabos, Dana, Reza·2016·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-016-2293-zPMC PMC5056132

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Abstract

Substance P is a peptide mainly secreted by neurons and is involved in many biological processes, including nociception and inflammation. Animal models have provided insights into the biology of this peptide and offered compelling evidence for the importance of substance P in cell-to-cell communication by either paracrine or endocrine signaling. Substance P mediates interactions between neurons and immune cells, with nerve-derived substance P modulating immune cell proliferation rates and cytokine production. Intriguingly, some immune cells have also been found to secrete substance P, which hints at an integral role of substance P in the immune response. These communications play important functional roles in immunity including mobilization, proliferation and modulation of the activity of immune cells. This review summarizes current knowledge of substance P and its receptors, as well as its physiological and pathological roles. We focus on recent developments in the immunobiology of substance P and discuss the clinical implications of its ability to modulate the immune response.

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Authors: Mashaghi, A., Marmalidou, A., Tehrani, M., Grace, P. M., Pothoulakis, C., & Dana, R.
Affiliations: Massachusetts Eye and Ear Infirmary (US)
University of Colorado Boulder (US)
University of California, Los Angeles (US)
Corresponding author: Dana, Reza
ORCID: Mashaghi, Alireza
Marmalidou, Anna
Tehrani, Mohsen
Grace, Peter M.
Pothoulakis, Charalabos
Dana, Reza
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2016-06-17
Volume: 73
Issue: 22
Pages: 4249-4264
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-016-2293-z
PMC: PMC5056132
OpenAlex: W2442224165
Cited by: 493
References: 258
Citations by year: 2026: 61 · 2025: 56 · 2024: 53 · 2023: 73 · 2022: 64 · 2021: 65 · 2020: 53 · 2019: 29 · 2018: 20 · 2017: 16 · 2016: 1
FWCI: 2.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (unspecified)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Foundation for the National Institutes of Health (R01 DK047343, EY020889, EY012963)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: substance P, neuropeptides, immune response, neuroimmune interactions, neurokinin-1 receptor, cytokine production, immune cell proliferation, inflammation, nociception, paracrine signaling, hormone signaling, immune cell mobilization
MeSH terms: Amino Acid Sequence, Animals, Disease, Humans, Immunity, Substance P, Signal Transduction, Immunomodulation

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Neuropeptide substance P and the immune response

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